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CLTCL1 is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Additionally we are shipping Clathrin, Heavy Polypeptide Like 1 Antibodies (16) and and many more products for this protein.
CLTCL1 is significantly upregulated in the developing human brain
Depletion of clathrin heavy chain (CHC (show CLTC ELISA Kits))17 (show CLTC ELISA Kits), but not the CHC22 clathrin isoform, by ribonucleic acid interference (RNAi) induces centrosome amplification and multipolar spindles.
CHC22 was required for retrograde trafficking of certain cargo molecules from endosomes to the trans-Golgi network.
Clathrin isoform CHC22 binds to sorting nexin 5 (show SNX5 ELISA Kits) through a coiled-coil domain.
role for CHC22 in formation of insulin (show INS ELISA Kits)-responsive GLUT4 (show SLC2A4 ELISA Kits) compartments in muscle & adipocytes; CHC22 associated with expanded GLUT4 (show SLC2A4 ELISA Kits) compartments in muscle in type 2 diabetes
EDR4 associates with CHC2 and modulates plant immunity by regulating the relocation of EDR1 (show PHC1 ELISA Kits) in Arabidopsis.[CHC2]
study presents a genetic characterization of the role of clathrin in endocytosis and auxin-mediated plant development; data demonstrate a fundamental role for clathrin function in cell polarity, growth, patterning, and organogenesis
This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
, Clathrin, heavy polypeptide D
, clathrin heavy chain 2
, clathrin heavy chain on chromosome 22
, clathrin, heavy polypeptide-like 1