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Claudin 12 Proteins (CLDN12)

CLDN12 encodes a member of the claudin family. Additionally we are shipping Claudin 12 Antibodies (51) and Claudin 12 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLDN12 9069 P56749
CLDN12 64945 Q9ET43
Rat CLDN12 CLDN12 500000  
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Top Claudin 12 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CLDN12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Claudin 12 (CLDN12) Interaction Partners

Human Claudin 12 (CLDN12) interaction partners

  1. Knockdown of claudin-3 (show CLDN3 Proteins), claudin-4 (show CLDN4 Proteins), and claudin-12, but not claudin-1 (show CLDN7 Proteins), increased breast cancer MCF-7 cell migration with maximal effects observed in claudin-12 siRNA-transfected cells.

  2. These findings strongly suggest that claudin-2 (show CLDN2 Proteins)- and/or claudin-12-based tight junctions form paracellular Ca(2 (show CA2 Proteins)+) channels in intestinal epithelia, and they highlight a novel mechanism behind vitamin D-dependent calcium homeostasis.

Mouse (Murine) Claudin 12 (CLDN12) interaction partners

  1. Claudin-12 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.

  2. 1,25(OH)2D3 downregulates cadherin-17 and upregulates claudin-2 (show CLDN2 Proteins) and claudin-12 in the intestine, suggesting that 1,25(OH)2D3, by regulating these epithelial cell junction proteins, can route calcium through the paracellular path

  3. These findings strongly suggest that claudin-2 (show CLDN2 Proteins)- and/or claudin-12-based tight junctions form paracellular Ca(2 (show CA2 Proteins)+) channels in intestinal epithelia, and they highlight a novel mechanism behind vitamin D-dependent calcium homeostasis.

Claudin 12 (CLDN12) Protein Profile

Protein Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protein have been found.

Gene names and symbols associated with Claudin 12 Proteins (CLDN12)

  • claudin 12 (cldn12)
  • claudin 12 (CLDN12)
  • claudin 12 (CpipJ_CPIJ011954)
  • claudin-12-like (LOC100391361)
  • claudin 12 (Cldn12)
  • claudin-12 protein
  • CLDN12 protein
  • DKFZp469F1620 protein
  • RGD1561053 protein
  • wu:fc27c11 protein
  • wu:fc37h01 protein
  • zgc:86588 protein

Protein level used designations for Claudin 12 Proteins (CLDN12)

claudin-12 , claudin 12 , claudin-12-like

GENE ID SPECIES
549605 Xenopus (Silurana) tropicalis
100174503 Pongo abelii
81593 Danio rerio
463521 Pan troglodytes
496360 Xenopus laevis
608397 Canis lupus familiaris
704058 Macaca mulatta
771872 Gallus gallus
6044554 Culex quinquefasciatus
100060361 Equus caballus
100137459 Papio anubis
100294674 Sus scrofa
100328633 Oryctolagus cuniculus
100391361 Callithrix jacchus
9069 Homo sapiens
64945 Mus musculus
500000 Rattus norvegicus
538709 Bos taurus
101108741 Ovis aries
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