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Claudin 14 Proteins (CLDN14)

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Additionally we are shipping CLDN14 Antibodies (78) and CLDN14 Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLDN14 23562 O95500
CLDN14 56173 Q9Z0S3
Rat CLDN14 CLDN14 304073  
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Top CLDN14 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

CLDN14 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Claudin 14 (CLDN14) Interaction Partners

Human Claudin 14 (CLDN14) interaction partners

  1. Rs1801725 (Ala986-Ser (show SIGLEC1 Proteins)), rs1042636 (Arg990Gly) of CaSR (show CASR Proteins) gene and rs219778, rs219780 (Thr229Thr) of CLDN14 gene were significantly associated with kidney stone disease in patients from the Eastern part of India.

  2. Claudin 14 expression was up-regulated in gastric cancer.

  3. CLDN14 mutations can contribute to the aetiology of childhood/congenital deafness in Moroccan patients.

  4. Human Cldn-8 (show CLDN8 Proteins) and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4 (show CLDN4 Proteins).

  5. OPRM1 (show OPRM1 Proteins) genetic polymorphisms are associated with the plasma concentration of cotinine in a Taiwanese MMT cohort. Carriers with the major allele of SNP rs1799971 had a higher plasma cotinine concentration.

  6. The hearing loss due to novel CLDN14 mutations is prelingual, severe-to-profound with greater loss in the high frequencies.

  7. The CLDN14 promoter is activated by Trichostatin A (TSA (show PRDX2 Proteins)) treatment according to promoter reporter assays in HEK (show EPHA3 Proteins) 293 cells.

  8. Individuals with mutations of CLDN14 may have different degrees of hearing loss and the loss is greater at higher frequencies.

  9. The palmitoylation of claudin-14 is required for efficient localization into tight junctions but not stability or strand assembly.

  10. The ability of CLDN14 to be recruited to these junctions is crucial for the hearing process.

Mouse (Murine) Claudin 14 (CLDN14) interaction partners

  1. claudin-14-targeting miR (show MLXIP Proteins)-9 and miR (show MLXIP Proteins)-374, rather than promoter of the claudin-14 gene itself, regulated through histone deacetylation

  2. describe a CaSR (show CASR Proteins)-NFATc1 (show NFATC1 Proteins)-microRNA-claudin-14 signaling pathway in the kidney that underlies paracellular Ca(++) reabsorption through the tight junction

  3. Activation of the Ca(2 (show CA2 Proteins)+)-sensing receptor in the thick ascending limb increases Cldn14 expression, which in turn blocks the paracellular reabsorption of Ca(2 (show CA2 Proteins)+).

  4. MiR (show MLXIP Proteins)-9 and miR (show MLXIP Proteins)-374 transcript levels are regulated by extracellular Ca(++) in a reciprocal manner as claudin-14.

  5. To explore the role of claudin 14 in the inner ear and in other tissues we created a mouse model by a targeted deletion of Cldn14.

  6. We generated claudin 11 (show CLDN11 Proteins)/claudin 14 double-deficient mice, which exhibit deafness, neurological deficits, and male sterility. Kidney function and ion balance are not significantly affected.

CLDN14 Protein Profile

Protein Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with Claudin 14 Proteins (CLDN14)

  • claudin 14 (cldn14)
  • claudin 14 (CLDN14)
  • claudin 14 (Cldn14)
  • claudin 14 (LOC100346496)
  • AI851731 protein
  • claudin-14 protein
  • CLDN14 protein
  • DFNB29 protein

Protein level used designations for Claudin 14 Proteins (CLDN14)

claudin 14 , claudin-14

GENE ID SPECIES
444474 Xenopus laevis
470085 Pan troglodytes
783180 Bos taurus
23562 Homo sapiens
56173 Mus musculus
304073 Rattus norvegicus
487751 Canis lupus familiaris
100302017 Sus scrofa
100726532 Cavia porcellus
427982 Gallus gallus
100346496 Oryctolagus cuniculus
101109068 Ovis aries
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