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CLDN17 encodes a member of the claudin family. Additionally we are shipping Claudin 17 Kits (20) and Claudin 17 Antibodies (19) and many more products for this protein.
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The structural features of Cldn17 contributing to anion channel formation are presented in this work.
Claudin 17 expression was down-regulated in gastric cancer.
CLDN17, clustered with CLDN8 (show CLDN8 Proteins) at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11.
, human CLDN17 gene for claudin-17