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Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. Additionally we are shipping Claudin 6 Antibodies (108) and Claudin 6 Kits (22) and many more products for this protein.
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claudin-6 is expressed in the developing pronephric tubule and duct but not glomus. Knockdown of claudin-6 by specific morpholino led to severe defects in pronephros tubular morphogenesis and blocked the terminal differentiation of the tubule cells.
Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN (show OCLN Proteins)) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry.
The expression of ASK1 (show MAP3K5 Proteins) is correlated with the level of claudin-6 in cervical carcinoma cells and tissues.
High levels of CLDN6 are associated with non-small-cell lung cancer.
The expression of claudin-6 was down regulated in gastric cancer tissue.
Only some hepatitis C virus strains efficiently use CLDN6 for infection.
This work provides a proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture.
Although claudin-6 and claudin-9 (show CLDN9 Proteins) can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9 (show CLDN9 Proteins).
ASK1 (show MAP3K5 Proteins) signal may play a positive role in the inhibitory effect of claudin-6 in breast cancer.
Our results show that claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas
CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in a variety of other pediatric CNS and soft tissue tumors.
Over-expression of Claudin 6 during embryogenesis delays lung morphogenesis.
Cldn6 is expressed by pulmonary epithelium during lung organogenesis.
The Inv (show INVS Proteins)-Cldn6-CDelta206 transgenic mice displayed a developmental delay in epidermal permeability barrier formation, as shown by the expression of keratins and Cldns, and by X-Gal (show GAL Proteins) penetration assays.
the normally robust injury response mechanism of the epidermis is lost in the aging Involucrin (show IVL Proteins)-Cldn6-CDelta196 transgenic epidermis
Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.
Cldn6 plays a role in the differentiation processes of the epidermis and hair follicle
Claudin-6 mRNA was found to be differentially expressed in four different adipose tissues, and up-regulated in each fat depot of mice fed a high-fat diet. Levels of claudin-6 transcripts were increased during differentiation of 3T3-L1 ce
developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13
Results demonstrate that the overexpression of a tail truncation mutant of claudin 6 (Cldn6) mislocalizes Cldn6 and other Cldn proteins to the cytoplasm and triggers a postnatal increase in proliferation and aberrant differentiation of the epidermis.
Tight junctions containing claudin 6 are essential for blastocyst formation in preimplantation mouse embryos
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.
, tight junction molecule claudin 6