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Claudin 8 Proteins (CLDN8)

CLDN8 encodes a member of the claudin family. Additionally we are shipping CLDN8 Antibodies (55) and CLDN8 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLDN8 9073 P56748
CLDN8 54420 Q9Z260
Rat CLDN8 CLDN8 304124  
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Top CLDN8 Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days

CLDN8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Claudin 8 (CLDN8) Interaction Partners

Human Claudin 8 (CLDN8) interaction partners

  1. Findings suggest a new mechanistic pathway in inflammatory bowel disease in which MiR (show MLXIP Proteins)-223 functions as a proinflammatory molecule targeting CLDN8 in the IL23 (show IL23A Proteins) pathway.

  2. High Claudin 8 Contributes to Malignant Proliferation in Osteosarcoma.

  3. the expression of claudin-5 (show CLDN5 Proteins) and claudin-9 (show CLDN9 Proteins) was down-regulated while the expression of claudin-8 was up-regulated in cervical carcinoma tissues compared with adjacent non-neoplastic tissues.

  4. Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4 (show CLDN4 Proteins).

  5. claudin-7 (show CLDN7 Proteins) and claudin-8 have potential use as immunohistochemical biomarkers in the differential diagnosis of chromophobe renal cell carcinoma (show MOK Proteins) and oncocytoma

  6. Na(+) absorption is paralleled by claudin-8-mediated sealing of the paracellular barrier to prevent Na(+) back-leakage, supporting steep Na(+) gradients in distal colon.

  7. the combination of CK7 (show KRT7 Proteins), S100A1 (show S100A1 Proteins) and claudin 8 immunohistochemistry can be useful for classifying tumours of overlapping histology as chromophobe renal cell carcinoma (show MOK Proteins) or renal oncocytomas.

  8. CLDN8, clustered with CLDN17 (show CLDN17 Proteins) at human chromosome 21q22.11, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C.

Cow (Bovine) Claudin 8 (CLDN8) interaction partners

  1. We found that CLDN8 was expressed by both spermatogonia and a subset of Sertoli cells in the bovine testis.

Mouse (Murine) Claudin 8 (CLDN8) interaction partners

  1. KLHL3 (show KLHL3 Proteins) regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8

  2. Claudin-8 is expressed at the variety of epithelial tissues in inner ear including stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.

  3. data show that claudin-4 (show CLDN4 Proteins) interacts with claudin-8 and that their association is required for the anion-selective paracellular pathway in the collecting duct

  4. claudin-8 was found to be expressed primarily at the tight junction along the entire aldosterone-sensitive distal nephron and in the late segments of the thin descending limbs of long-looped nephrons

CLDN8 Protein Profile

Protein Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.

Gene names and symbols associated with Claudin 8 Proteins (CLDN8)

  • claudin-8-like (LOC100053505)
  • claudin 8 (CLDN8)
  • claudin 8 (cldn8)
  • claudin 8 (Cldn8)
  • AI648025 protein
  • CLDN8 protein
  • wu:fa01e05 protein
  • zgc:91900 protein

Protein level used designations for Claudin 8 Proteins (CLDN8)

claudin 8 , claudin-8

100053505 Equus caballus
427974 Gallus gallus
445278 Danio rerio
474085 Pan troglodytes
9073 Homo sapiens
538761 Bos taurus
54420 Mus musculus
304124 Rattus norvegicus
478401 Canis lupus familiaris
100302021 Sus scrofa
101106811 Ovis aries
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