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CSTF2 encodes a nuclear protein with an RRM (RNA recognition motif) domain. Additionally we are shipping CSTF2 Antibodies (74) and CSTF2 Proteins (4) and many more products for this protein.
The results suggest that CstF-64 plays a key role in modulating the cell cycle in embryonic stem cells while simultaneously controlling histone mRNA 3' end processing.
ELL2 and CstF-64 tracked together with RNA polymerase II across the Igh mu- and gamma-gene segments
hnRNP H (show HNRNPH1 ELISA Kits) binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H (show HNRNPH1 ELISA Kits) competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform.
CstF-64 is dispensable for the expression/3'-end processing of Star-PAP (show TUT1 ELISA Kits) target mRNAs.CstF-64 and 3'-UTR (show UTS2R ELISA Kits) cis (show CISH ELISA Kits)-element determine Star-PAP (show TUT1 ELISA Kits) specificity for target mRNA selection by excluding poly A polymerase (show PAPOLA ELISA Kits).
CstF64, an essential polyadenylation factor, is a master regulator of 3'-UTR (show UTS2R ELISA Kits) shortening across multiple tumour types.
CstF64 is central to the function of a heat-labile factor, composed of cleavage/polyadenylation specificity factor (show CPSF1 ELISA Kits), symplekin (show SYMPK ELISA Kits), and cleavage stimulation factor 64 and appears to be at least partly responsible for its cell cycle regulation.
CSTF2 is likely to play an important role in lung carcinogenesis and be a prognostic biomarker in the clinic.
nuclear accumulation of CstF-64 depends on binding to CstF-77 not symplekin; interaction between CstF-64/CstF-64Tau and CstF-77 are important for maintenance of nuclear levels of CstF complex components and intracellular localization, stability, function
The Hinge domain is necessary for CstF-64 interaction with CstF-77 and consequent nuclear localization.
dynamics of the CstF-64 RNA-binding domain, both free and bound to two GU-rich RNA sequences that represent polyadenylation regulatory elements, by NMR Spectroscopy
CstF64 (cstf2) and not other CstF subunits induced by lipopolysaccharide (LPS (show IRF6 ELISA Kits)) in murine macrophages and changes polyA site use
Describes the induction of CSTF2 in the growth phase of cells.
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs.
cleavage stimulation factor subunit 2
, cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
, cleavage stimulation factor 64 kilodalton subunit
, CF-1 64 kDa subunit
, CSTF 64 kDa subunit
, Cleavage stimulation factor 64 kDa subunit
, alphaCstF-64 variant 4
, betaCstF-64 variant 1
, betaCstF-64 variant 3
, cleavage stimulation factor 64 kDa subunit
, cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa
, betaCstF-64 variant 2