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anti-Cleavage and Polyadenylation Factor I Subunit 1 (CLP1) Antibodies

Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. Additionally we are shipping CLP1 Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CLP1 10978 Q92989
CLP1 311166 Q5PQL4
CLP1 98985 Q99LI9
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Top anti-CLP1 Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Host: RabbitTarget Name: CLP1Antibody Dilution: 1.0ug/mlSample Tissue: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB CLP1 Antibody (C-term)  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CLP1 antibody detected the CLP1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated WB Western Blot analysis of HEAB expression in transfected 293T cell line by HEAB monoclonal antibody (M01), clone 8D5. Lane 1: HEAB transfected lysate(47.946 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using CLP1, antibody at 1:200 dilution. WB Image Sample (30 ug of whole cell lysate) A: Hela B: Hep G2 , 10% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated ELISA, WB Western Blot analysis of HEAB expression in transfected 293T cell line by HEAB monoclonal antibody (M01), clone 8D5.Lane 1: HEAB transfected lysate(47.946 KDa).Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged CLP1 is 1 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC (fp), IF, WB 100 μL Log in to see 6 to 11 Days
$485.71
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB   50 μg Log in to see 8 to 10 Days
$551.83
Details

CLP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine) ,


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More Antibodies against CLP1 Interaction Partners

Human Cleavage and Polyadenylation Factor I Subunit 1 (CLP1) interaction partners

  1. Study reports the identification of a human CLP1 (show HEXIM1 Antibodies) mutation that impairs tRNA splicing in vitro and causes a neurological syndrome involving both the central nervous system (CNS) and peripheral nervous system (PNS).

  2. Data link tRNA maturation to neuronal development and neurodegeneration through defective CLP1 (show HEXIM1 Antibodies) function in humans.

  3. the kinase hClp1 phosphorylates and licenses synthetic siRNAs to become assembled into RISC (show SCPEP1 Antibodies) for subsequent target RNA cleavage

  4. Expression of hClp1 in budding yeast can complement conditional and lethal mutations in the essential 5'-OH RNA kinase module of yeast or plant tRNA ligases.

  5. HEAB is a pre-mRNA 3'-end processing factor, which bridges two other pre-mRNA processing (show PRPF39 Antibodies) factors (CF Im and CPSF (show CPSF3 Antibodies)) and is involved in cleavage of the pre-mRNA. It can be UV-crosslinked to GTP (show AK3 Antibodies).

Mouse (Murine) Cleavage and Polyadenylation Factor I Subunit 1 (CLP1) interaction partners

  1. loss of CLP1 activity results in accumulation of a novel set of small RNA fragments derived from aberrant processing of tyrosine pre-transfer RNA; these tRNA fragments sensitize cells to oxidative-stress-induced (show SQSTM1 Antibodies) p53 (show TP53 Antibodies) activation and p53 (show TP53 Antibodies)-dependent cell death

  2. associates with MyoD (show MYOD1 Antibodies) and HDAC (show HDAC3 Antibodies) to restore skeletal muscle cell regeneration

  3. regulation of the CLP-1 levels is critical to cellular adaptation of the survival program that protects cardiomyocytes against stress

CLP1 Antigen Profile

Protein Summary

Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing\; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA- induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity).

Gene names and symbols associated with CLP1

  • cleavage and polyadenylation factor I subunit 1 (CLP1) antibody
  • cleavage and polyadenylation factor I subunit 1 (Clp1) antibody
  • CLP1, cleavage and polyadenylation factor I subunit (Clp1) antibody
  • CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) (CLP1) antibody
  • lysine (K)-specific methyltransferase 2D (KMT2D) antibody
  • AI462438 antibody
  • hClp1 antibody
  • Heab antibody
  • MLL2 antibody
  • RGD1307679 antibody

Protein level used designations for CLP1

ATP/GTP-binding protein , CLP1, cleavage and polyadenylation factor I subunit, homolog , homolog of yeast CFIA subunit Clp1p , polyadenylation factor Clp1 , polynucleotide kinase Clp1 , polyribonucleotide 5'-hydroxyl-kinase Clp1 , pre-mRNA cleavage complex II protein Clp1 , myeloid/lymphoid or mixed-lineage leukemia 2

GENE ID SPECIES
10978 Homo sapiens
311166 Rattus norvegicus
98985 Mus musculus
506507 Bos taurus
423131 Gallus gallus
506805 Bos taurus
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