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Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) ELISA Kits

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. Additionally we are shipping Cleavage and Polyadenylation Specific Factor 4, 30kDa Antibodies (58) and Cleavage and Polyadenylation Specific Factor 4, 30kDa Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Rat CPSF4 CPSF4 100360200  
Anti-Mouse CPSF4 CPSF4 54188 Q8BQZ5
Anti-Human CPSF4 CPSF4 10898 O95639
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More ELISA Kits for Cleavage and Polyadenylation Specific Factor 4, 30kDa Interaction Partners

Human Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) interaction partners

  1. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA

  2. CPSF4 upregulates human TERT (show TERT ELISA Kits) promoter activity, human TERT (show TERT ELISA Kits) expression and telomerase activity.

  3. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A).

  4. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma.

  5. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding.

Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Antigen Profile

Antigen Summary

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Gene names and symbols associated with CPSF4

  • cleavage and polyadenylation specific factor 4, 30kDa (CPSF4) antibody
  • cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4) antibody
  • cleavage and polyadenylation specific factor 4 (LOC733099) antibody
  • cleavage and polyadenylation specific factor 4 (LOC100360200) antibody
  • cleavage and polyadenylation specific factor 4, 30kDa (cpsf4) antibody
  • cleavage and polyadenylation specific factor 4, 30kDa (LOC100224162) antibody
  • cleavage and polyadenylation specific factor 4 (Cpsf4) antibody
  • 30kDa antibody
  • C79664 antibody
  • CPSF30 antibody
  • NAR antibody
  • NEB1 antibody

Protein level used designations for CPSF4

no arches , GLEAN_10339 , cleavage and polyadenylation specific factor 4 , cleavage and polyadenylation specificity factor subunit 4 , cleavage and polyadenylation specific factor 4, 30kDa , CPSF 30 kDa subunit , cleavage and polyadenylation specific factor 4, 30kD subunit , cleavage and polyadenylation specificity factor 30 kDa subunit , clipper homolog , clipper/CPSF 30K , musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit , NS1 effector domain-binding protein 1 , cleavage-polyadenylation specificity factor, 30kD , neb-1 , no arches homolog , no arches-like zinc finger protein , cleavage-polyadenylation specificity factor, 30 kD

GENE ID SPECIES
463572 Pan troglodytes
660072 Tribolium castaneum
733099 Bombyx mori
100360200 Rattus norvegicus
444766 Xenopus laevis
493312 Xenopus (Silurana) tropicalis
708119 Macaca mulatta
100224162 Taeniopygia guttata
54188 Mus musculus
304277 Rattus norvegicus
10898 Homo sapiens
416494 Gallus gallus
489859 Canis lupus familiaris
280875 Bos taurus
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