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Cleavage and Polyadenylation Specific Factor 4, 30kDa Proteins (CPSF4)

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. Additionally we are shipping Cleavage and Polyadenylation Specific Factor 4, 30kDa Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CPSF4 100360200  
CPSF4 54188 Q8BQZ5
CPSF4 10898 O95639
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Top Cleavage and Polyadenylation Specific Factor 4, 30kDa Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,619.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,619.83
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$413.21
Details

CPSF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

Human ,
,

Top referenced Cleavage and Polyadenylation Specific Factor 4, 30kDa Proteins

  1. Human CPSF4 Protein expressed in Escherichia coli (E. coli) - ABIN1098798 : Barabino, Hübner, Jenny, Minvielle-Sebastia, Keller: The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. in Genes & development 1997 (PubMed)
    Show all 2 references for ABIN1098798

More Proteins for Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Interaction Partners

Human Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) interaction partners

  1. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA

  2. CPSF4 upregulates human TERT (show TERT Proteins) promoter activity, human TERT (show TERT Proteins) expression and telomerase activity.

  3. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A).

  4. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma.

  5. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding.

Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Protein Profile

Protein Summary

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Gene names and symbols associated with CPSF4

  • cleavage and polyadenylation specific factor 4, 30kDa (CPSF4)
  • cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4)
  • cleavage and polyadenylation specific factor 4 (LOC733099)
  • cleavage and polyadenylation specific factor 4 (LOC100360200)
  • cleavage and polyadenylation specific factor 4, 30kDa (cpsf4)
  • cleavage and polyadenylation specific factor 4, 30kDa (LOC100224162)
  • cleavage and polyadenylation specific factor 4 (Cpsf4)
  • 30kDa protein
  • C79664 protein
  • CPSF30 protein
  • NAR protein
  • NEB1 protein

Protein level used designations for CPSF4

no arches , GLEAN_10339 , cleavage and polyadenylation specific factor 4 , cleavage and polyadenylation specificity factor subunit 4 , cleavage and polyadenylation specific factor 4, 30kDa , CPSF 30 kDa subunit , cleavage and polyadenylation specific factor 4, 30kD subunit , cleavage and polyadenylation specificity factor 30 kDa subunit , clipper homolog , clipper/CPSF 30K , musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit , NS1 effector domain-binding protein 1 , cleavage-polyadenylation specificity factor, 30kD , neb-1 , no arches homolog , no arches-like zinc finger protein , cleavage-polyadenylation specificity factor, 30 kD

GENE ID SPECIES
463572 Pan troglodytes
660072 Tribolium castaneum
733099 Bombyx mori
100360200 Rattus norvegicus
444766 Xenopus laevis
493312 Xenopus (Silurana) tropicalis
708119 Macaca mulatta
100224162 Taeniopygia guttata
54188 Mus musculus
304277 Rattus norvegicus
10898 Homo sapiens
416494 Gallus gallus
489859 Canis lupus familiaris
280875 Bos taurus
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