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anti-Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) Antibodies

The protein encoded by CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. Additionally we are shipping CPSF6 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CPSF6 432508 Q6NVF9
CPSF6 11052 Q16630
CPSF6 299811  
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Top anti-CPSF6 Antibodies at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IF, IHC, WB WB Suggested Anti-CPSF6 Antibody Titration: 0.3125ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB CPSF6 Antibody (N-term) (ABIN1881225) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the CPSF6 antibody detected the CPSF6 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, ELISA, WB CPSF6 monoclonal antibody (M10), clone 3F11 Western Blot analysis of CPSF6 expression in HeLa . Immunofluorescence of monoclonal antibody to CPSF6 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Mouse Un-conjugated WB CPSF6 monoclonal antibody (M07), clone 1C5. Western Blot analysis of CPSF6 expression in NIH/3T3. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to CPSF6 on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of CPSF6 expression in transfected 293T cell line by CPSF6 monoclonal antibody (M10), clone 3F11. Lane 1: CPSF6 transfected lysate(59.21 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days
$457.14
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$537.17
Details
Human Rabbit Un-conjugated IHC, WB CPSF6 antibody was used for immunohistochemistry at a concentration of 16.0 ug/ml to stain Skeletal muscle cells (arrows) in Human Muscle. Magnification is at 400X CPSF6 antibody used at 0.3125 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details

CPSF6 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human ,
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Rat (Rattus)


Top referenced anti-CPSF6 Antibodies

  1. Human Polyclonal CPSF6 Primary Antibody for WB - ABIN1881225 : Lee, Ambrose, Martin, Oztop, Mulky, Julias, Vandegraaff, Baumann, Wang, Yuen, Takemura, Shelton, Taniuchi, Li, Sodroski, Littman, Coffin, Hughes, Unutmaz, Engelman, KewalRamani: Flexible use of nuclear import pathways by HIV-1. in Cell host & microbe 2010 (PubMed)
    Show all 5 references for ABIN1881225

  2. Human Monoclonal CPSF6 Primary Antibody for IF, ELISA - ABIN524445 : Kim, Yamamoto, Chen, Aida, Wada, Handa, Yamaguchi: Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. in Genes to cells : devoted to molecular & cellular mechanisms 2010 (PubMed)
    Show all 2 references for ABIN524445

  3. Chicken Polyclonal CPSF6 Primary Antibody for IF, IHC - ABIN2779018 : Rual, Venkatesan, Hao, Hirozane-Kishikawa, Dricot, Li, Berriz, Gibbons, Dreze, Ayivi-Guedehoussou, Klitgord, Simon, Boxem, Milstein, Rosenberg, Goldberg, Zhang, Wong, Franklin, Li, Albala, Lim et al.: Towards a proteome-scale map of the human protein-protein interaction network. ... in Nature 2005 (PubMed)

More Antibodies against CPSF6 Interaction Partners

Mouse (Murine) Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. Here we report that the CFIm subunits NUDT21/CPSF5 (show NUDT21 Antibodies) and CPSF6 are highly enriched in mouse male germ cells relative to somatic cells.

Human Cleavage and Polyadenylation Specific Factor 6, 68kDa (CPSF6) interaction partners

  1. integration targeting proceeds via two distinct mechanisms: capsid-CPSF6 binding directs HIV-1 to actively transcribed euchromatin, where the integrase-LEDGF/p75 (show PSIP1 Antibodies) interaction drives integration into gene bodies.

  2. NUP153 (show NUP153 Antibodies) and CPSF6 have overlapping binding sites, but each makes unique capsid monomers (CA) interactions. Multiple ligands share an overlapping interface in HIV-1 capsid that is lost upon viral disassembly.

  3. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.

  4. study uncovers two opposing CA-dependent functions of CPSF6 in HIV-1 replication in vivo; however, the benefit for binding CPSF6 appears to outweigh the cost, providing support for a vital function of CPSF6 during HIV-1 replication in vivo

  5. CPSF6 binds specifically to a novel proteinprotein interface on the N-terminal domain of HIV-1 capsid protein (CA).

  6. These results suggested that inhibition of HIV-1 by TNPO3 (show TNPO3 Antibodies)-depleted cells requires CPSF6.

  7. Loss-of-function of CFIm68 and CFIm25 (show NUDT21 Antibodies) leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells.

  8. TNPO3 (show TNPO3 Antibodies) promotes HIV-1 infectivity indirectly, by shifting the CA-binding protein CPSF6 to the nucleus, thus preventing the excessive HIV-1 CA stability that would otherwise result from cytoplasmic accumulation of CPSF6.

  9. A carboxy-terminally truncated human CPSF6 lacking residues encoded by exon 6 inhibits HIV-1 cDNA synthesis and promotes capsid disassembly.

  10. A 9-residue stretch of hydrophobic amino acids in CPSF6 restricts HIV-1 infection through an interaction with capsid.

CPSF6 Antigen Profile

Protein Summary

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.

Gene names and symbols associated with CPSF6

  • cleavage and polyadenylation specific factor 6, 68kDa (CPSF6) antibody
  • cleavage and polyadenylation specific factor 6, 68kDa (cpsf6) antibody
  • cleavage and polyadenylation specific factor 6, 68kDa (LOC100220791) antibody
  • cleavage and polyadenylation specific factor 6 (cpsf6) antibody
  • cleavage and polyadenylation specific factor 6 (Cpsf6) antibody
  • cleavage and polyadenylation specific factor 6, 68kDa (Cpsf6) antibody
  • 4733401N12Rik antibody
  • AI256641 antibody
  • CFIM antibody
  • CFIM68 antibody
  • CPSF6 antibody
  • HPBRII-4 antibody
  • HPBRII-7 antibody
  • wu:fa22f12 antibody
  • zgc:85819 antibody

Protein level used designations for CPSF6

cleavage and polyadenylation specific factor 6, 68kDa , cleavage and polyadenylation specificity factor subunit 6 , cleavage and polyadenylation specific factor 6, 68 kD subunit , CPSF 68 kDa subunit , cleavage and polyadenylation specificity factor 68 kDa subunit , cleavage factor Im complex 68 kDa subunit , pre-mRNA cleavage factor I, 68kD subunit , pre-mRNA cleavage factor Im (68kD) , pre-mRNA cleavage factor Im 68 kDa subunit , protein HPBRII-4/7

GENE ID SPECIES
452068 Pan troglodytes
446580 Xenopus laevis
548671 Xenopus (Silurana) tropicalis
100013834 Monodelphis domestica
100220791 Taeniopygia guttata
100589466 Nomascus leucogenys
327069 Danio rerio
432508 Mus musculus
417844 Gallus gallus
11052 Homo sapiens
474441 Canis lupus familiaris
100152191 Sus scrofa
768231 Bos taurus
299811 Rattus norvegicus
100174771 Pongo abelii
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