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Clock Homolog (Mouse) Proteins (CLOCK)

CLOCK product regulates circadian rhythm and metabolism. Additionally we are shipping CLOCK Antibodies (109) and CLOCK Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLOCK 12753 O08785
CLOCK 9575 O15516
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Top CLOCK Proteins at

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

CLOCK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

More Proteins for Clock Homolog (Mouse) (CLOCK) Interaction Partners

Fruit Fly (Drosophila melanogaster) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. these results demonstrate a key role of Clk post-transcriptional control in stabilizing circadian transcription.

  2. Our findings suggest a novel role for clock protein (show ARNTL Proteins) phosphorylation in governing the relative strengths of entraining modalities by adjusting the dynamics of circadian gene expression.

  3. These results demonstrate that CLK phosphorylation influences the circadian period by regulating CLK activity and progression through the feedback loop.

  4. Computational dissection of CLK/CYC (show COX6C Proteins) context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites

  5. usp8 (show USP8 Proteins) loss of function (RNAi) or expression of a dominant-negative form of the protein (USP8 (show USP8 Proteins)-DN) enhances CLK/CYC (show COX6C Proteins) transcriptional activity and alters fly locomotor activity rhythms

  6. CLK has specific targets in different tissues, implying that important CLK partner proteins and/or mechanisms contribute to gene-specific and tissue-specific regulation

  7. CTRIP destabilizes CLK protein in a PER-independent manner and helps degradation of phosphorylated PER and TIM in the morning

  8. dPER(DeltaCBD) does not provoke the daily hyperphosphorylation of dCLOCK, indicating that direct interactions between dPER and dCLOCK are necessary for the dCLOCK phosphorylation

  9. findings show that Clk and cyc (show COX6C Proteins) act during starvation to modulate the conflict of whether flies sleep or search for food

  10. Here we examined the consequences of loss of clock function on reproductive fitness in Drosophila melanogaster with mutated period (per(0)), timeless (tim(0)), cycle (cyc (show COX6C Proteins)(0)), and Clock (Clk(Jrk)) genes

Zebrafish Clock Homolog (Mouse) (CLOCK) interaction partners

  1. effect of CRY (show CRY2 Proteins) in repressing transcription mediated by CLOCK-BMAL heterodimer

Mouse (Murine) Clock Homolog (Mouse) (CLOCK) interaction partners

  1. Both clock- and feeding-dependent mechanisms regulate the daily accumulation of key enzymes in polyamine biosynthesis through rhythmic binding of BMAL1 (show ARNTL Proteins):CLOCK to conserved DNA elements

  2. RNA interference screens reveal the heterodimeric, circadian rhythm Transcription factors Clock and Bmal1 (show ARNTL Proteins) as genes required for the growth of acute myeloid leukemia (show BCL11A Proteins) cells in vitro and in vivo.

  3. Findings indicate that CLOCK protein (show ARNTL Proteins) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  4. Irp2 (show IREB2 Proteins) mRNA transcription is promoted by circadian clock genes, including BMAL1 (show ARNTL Proteins), and the CLOCK heterodimer.

  5. In CLOCK-deficient fibroblasts, knockdown of Npas2 (show NPAS2 Proteins) leads to arrhythmicity, suggesting that NPAS2 (show NPAS2 Proteins) can compensate for loss of CLOCK in peripheral cells as well as in suprachiasmatic nucleus.

  6. SERPINA3K (show SERPINA3K Proteins) is involved in the Clock gene-mediated male fertility by regulating acrosin (show ACR Proteins) activity and provide the first evidence that SERPINA3K (show SERPINA3K Proteins) could be regulated by Clock gene via retinoic acid-related orphan receptor (show NR1D2 Proteins) response elements.

  7. Circadian CLOCK Mediates Activation of Transforming Growth Factor-beta Signaling and Renal Fibrosis through Cyclooxygenase 2 (show PTGS2 Proteins).

  8. Propose that USF1 (show USF1 Proteins) is an important modulator of molecular and behavioral circadian rhythms in mammals via DNA-binding of the CLOCK:BMAL1 complex.

  9. Clock is a novel regulator of psoriasis-like skin inflammation in mice via direct modulation of IL-23R (show IL23R Proteins) expression in gamma/delta+ T cells

  10. clock gene Rev-erbalpha (show NR1D1 Proteins) and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling interact in the regulation of cell proliferation

Human Clock Homolog (Mouse) (CLOCK) interaction partners

  1. possible circadian rhythm in full-term placental expression

  2. Findings indicate that CLOCK protein (show ARNTL Proteins) plays an important role in fertility and its knockdown leads to reduction in reproduction and increased miscarriage risk.

  3. Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.

  4. when overexpressed, c-MYC (show MYC Proteins) is able to repress Per1 transactivation by BMAL1 (show ARNTL Proteins)/CLOCK via targeting selective E-box sequences. Importantly, upon serum stimulation, MYC (show MYC Proteins) was detected in BMAL1 (show ARNTL Proteins) protein complexes

  5. CLOCK, ARNTL (show ARNTL Proteins), and NPAS2 (show NPAS2 Proteins) gene polymorphisms may have a role in seasonal variations in mood and behavior

  6. minor polymorphisms of CLOCK may be associated with poor morning gastric motility, and may have a combinatorial effect with PER3.

  7. these findings suggest that sumoylation plays a critical role in the spatiotemporal co-activation of CLOCK-BMAL1 (show ARNTL Proteins) by CBP (show CREBBP Proteins) for immediate-early (show JUN Proteins) Per induction and the resetting of the circadian clock.

  8. the circadian gene hClock promoted CRC (show CALR Proteins) progression and inhibit tumor cell apoptosis in vitro and in vivo, while silencing hClock was able to reverse this effect.

  9. PASD1 (show PASD1 Proteins) is a circadian bHLH-PAS (show PASK Proteins) paralog repressor of CLOCK protein (show ARNTL Proteins) expression.

  10. The observed interaction effects provide converging evidence that the clock gene and OXT (show OXT Proteins)/AVP (show AVP Proteins) systems are intertwined and contribute to human prosociality.

Xenopus laevis Clock Homolog (Mouse) (CLOCK) interaction partners

  1. the second half of the photolyase homology region (PHR) of CRY (show CRY2 Proteins) is important for repression through facilitating interaction with CLOCK

CLOCK Protein Profile

Protein Summary

This gene product regulates circadian rhythm and metabolism. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and a DNA binding histone acetyltransferase. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Clock Homolog (Mouse) Proteins (CLOCK)

  • Clock (Clk)
  • clock homolog (mouse) (CLOCK)
  • clock circadian regulator (clock)
  • clock homolog (CLOCK)
  • clock (clock)
  • circadian locomotor output cycles kaput (Clock)
  • clock circadian regulator (Clock)
  • clock circadian regulator (CLOCK)
  • 5330400M04Rik protein
  • bHLHe8 protein
  • bHLHe10 protein
  • CG7391 protein
  • clk protein
  • clock protein
  • dClck protein
  • dclk protein
  • dCLK/JRK protein
  • dClock protein
  • Dmel\\CG7391 protein
  • Jerk protein
  • jrk protein
  • KAT13D protein
  • mKIAA0334 protein
  • PAS1 protein
  • Xclk protein
  • XClock protein
  • zCLOCK1 protein
  • zfCLOCK1 protein

Protein level used designations for Clock Homolog (Mouse) Proteins (CLOCK)

CG7391-PA , CG7391-PD , CG7391-PF , CG7391-PG , CG7391-PH , CLOCK , Clk-PA , Clk-PD , Clk-PF , Clk-PG , Clk-PH , clock , dClock , clock homolog (mouse) , clock homolog , circadian locomoter output cycles protein kaput , circadian locomoter output cycles protein kaput-like , Clock1a , clk1 , circadian locomoter output cycles kaput , mCLOCK , rCLOCK , circadian locomoter output cycles kaput protein , class E basic helix-loop-helix protein 8 , circadian rhythmicity protein CLOCK

38872 Drosophila melanogaster
461312 Pan troglodytes
475145 Canis lupus familiaris
786637 Bos taurus
100008576 Meleagris gallopavo
100017022 Monodelphis domestica
100034166 Equus caballus
100038163 Xenopus (Silurana) tropicalis
100171391 Ovis aries
100172630 Pongo abelii
100349684 Oryctolagus cuniculus
100407407 Callithrix jacchus
30140 Danio rerio
100606130 Nomascus leucogenys
100628097 Sus scrofa
12753 Mus musculus
60447 Rattus norvegicus
9575 Homo sapiens
399157 Xenopus laevis
373991 Gallus gallus
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