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mouse homolog is a putative ATPase and member of the Clp/HSP104 family. Additionally we are shipping and CLPB Kits (2) and many more products for this protein.
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Human Polyclonal CLPB Primary Antibody for ELISA - ABIN314275
Satpute-Krishnan, Langseth, Serio: Hsp104-dependent remodeling of prion complexes mediates protein-only inheritance. in PLoS biology 2007
Case Reports: bi-allelic CLPB mutations cause cataract, renal cysts, nephrocalcinosis and 3-methylglutaconic aciduria, a novel disorder of mitochondrial protein (show COX6B2 Antibodies) disaggregation.
Disruption of CLPB is associated with congenital microcephaly, severe encephalopathy and 3-methylglutaconic aciduria
ClpB can passively thread soluble denatured proteins.
Mutations in CLPB define a syndrome with intellectual disability, congenital neutropenia, progressive brain atrophy, movement disorder, cataracts, and 3-methylglutaconic aciduria.
CLPB is proposed to function as a mitochondrial chaperone involved in disaggregation of misfolded proteins, resulting from stress such as heat denaturation.
ClpB-DnaK reactivated all aggregated fusion proteins with similar efficiency, without unfolding native domains, demonstrating that partial threading of the misfolded moiety is sufficient to solubilize aggregates.
formation of the DnaK-ClpB bichaperone network is a three step process
mouse homolog is a putative ATPase and member of the Clp/HSP104 family
ClpB caseinolytic peptidase B homolog
, caseinolytic peptidase B protein homolog
, suppressor of K+ transport defect 3
, suppressor of potassium transport defect 3