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CD1e encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. Additionally we are shipping Cluster of Differentiation 1e Antibodies (47) and Cluster of Differentiation 1e Kits (1) and many more products for this protein.
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for isoforms CD1b (show CD1B Proteins) through CD1e, our simulations show the near-complete collapse of the hydrophobic cavities in the absence of the antigen. This event results from the spontaneous closure of the binding domain entrance, flanked by two alpha-helices.
The interaction of LAPTM5 (show LAPTM5 Proteins) with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 (show LAPTM5 Proteins) might influence the role of CD1e in the presentation of lipid antigens.
Deciphering the role of CD1e protein in mycobacterial phosphatidyl-myo-inositol mannosides (PIM (show PIM1 Proteins)) processing for presentation by CD1b (show CD1B Proteins) to T lymphocytes
in the late endosomes/lysosomes of dendritic cells, the acid pH promotes the binding of lipid antigens to CD1e through increased hydrophobic and ionic interactions
allelic variation in CD1E does not play a major role in determining multifocal motor neuropathy susceptibility.
In Guillain-Barre syndrome, an initially positive association study with polymorphism of CD1A (show CD1A Proteins) and CD1E genes was not confirmed
CD1e may positively or negatively affect lipid presentation by CD1b (show CD1B Proteins), CD1c (show CD1C Proteins), and CD1d (show CD1D Proteins).
These data support that CD1e could have evolved to mediate lipid-exchange/editing processes.
CD1A (show CD1A Proteins) and CD1E polymorphisms contribute to the polygenic susceptibility to multiple sclerosis
CD1E and CD1A (show CD1A Proteins) genes may be involved in networks which determine susceptibility to multiple sclerosis types RR-MS and PP-MS, respectively.
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found\; however, their biological validity has not been determined.
CD1E antigen, e polypeptide
, T-cell surface glycoprotein CD1e, membrane-associated
, differentiation antigen CD1-alpha-3
, leukocyte differentiation antigen
, thymocyte antigen CD1E
, T-cell surface glycoprotein CD1e, soluble