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Coagulation Factor VIII Proteins (F8)

F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. Additionally we are shipping Factor VIII Antibodies (343) and Factor VIII Kits (45) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F8 14069 Q06194
F8 2157 P00451
Rat F8 F8 302470  
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Top Factor VIII Proteins at antibodies-online.com

Showing 10 out of 26 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Influenza C Virus His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag,S tag 100 μg Log in to see 11 to 13 Days
$422.40
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Escherichia coli (E. coli) Dog His tag 100 μg Log in to see 11 to 13 Days
$841.50
Details
HOST_Escherichia coli (E. coli) Wild boar His tag 100 μg Log in to see 11 to 13 Days
$859.10
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_CHO Human Un-conjugated   1000 IU Log in to see 3 to 4 Days
$4,763.79
Details
Hamster Human Un-conjugated   250 IU Log in to see 6 to 11 Days
$3,085.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$605.82
Details

F8 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
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More Proteins for Coagulation Factor VIII (F8) Interaction Partners

Zebrafish Coagulation Factor VIII (F8) interaction partners

  1. gene is flanked by factor VII (show TH Proteins) and factor X genes; gene encodes a protein homologous to factor VII (show TH Proteins), but lacks critical residues for factor VII (show TH Proteins) activity; functions as an inhibitor of blood coagulation in biochemical assays using zebrafish or human plasmas

Mouse (Murine) Coagulation Factor VIII (F8) interaction partners

  1. data demonstrate that infusion of platelets containing FVIII triggers neither primary nor memory anti-FVIII immune response in FVIII(null) mice

  2. Both platelet-VWF (show VWF Proteins) and plasma-VWF (show VWF Proteins) are required for optimal platelet-derived FVIII gene therapy for hemophilia A in the presence of inhibitors.

  3. These data support the investigation of FVIII orthologs as treatment modalities in both the congenital and acquired FVIII inhibitor settings.

  4. Activatable bioengineered FIX molecules with FVIII-independent activity might be a promising tool for improving hemophilia A treatment, especially for patients with inhibitors.

  5. This study demonstrated that FVIIIa interacts with Low-density lipoprotein receptor-related protein 1 (show LRP1 Proteins) cluster III.

  6. a fragment containing only approximately 20% of the VWF (show VWF Proteins) sequence is sufficient to support FVIII stability in vivo

  7. Endothelial cells from multiple, but not all, tissues contribute to the plasma FVIII pool in the mouse.

  8. Endothelial cells are the predominant, and possibly exclusive, source of plasma FVIII.

  9. Micro-computed tomography analysis of distal tibia metaphyses also revealed for the first time a major impact of the FVIII/thrombin (show F2 Proteins)/PAR1 (show F2R Proteins) axis on the dynamic bone structure, showing reduced bone.

  10. Findings indicate that improving protein trans-splicing by inter-chain disulfide bonding is a promising approach for increasing the efficacy of dual-vector based FVIII gene transfer.

Human Coagulation Factor VIII (F8) interaction partners

  1. Letter: report deep intronic variants of factor VII (show TH Proteins) gene in hemophilia A.

  2. Coagulation test results showed that the presence of double Glu113Asp, Arg593Cys mutations has a slightly synergistic effect on FVIII activity.

  3. Report a dose-response relationship between high FVIII levels and risk of death in venous thrombosis patients and in individuals from the general population.

  4. Case Report: P1809L mutation in A3 induced the conformational change in the FVIII molecule that hampered antigenic determinant(s) located in the C2 domain and might result in the inhibitor development.

  5. FVIII predicted venous thrombosis recurrence in a dose-response fashion, overall and in several subgroups, and is a strong candidate component of recurrence prediction tools.

  6. Interaction between VWF (show VWF Proteins) and FVIII in treating VWD (show VWF Proteins).

  7. a grading system for FVIII mutations combining the severity determinants was developed and the grading pattern correlates with hemophilia phenotype, is reported.

  8. Among the seven HA families whose coding region of the FVIII gene was directly sequenced,five patients and certain of their female relatives had mutations detected.

  9. Stimulated GMVECs and HUVECs were found to secrete cell-anchored ultra-large VWF (show VWF Proteins) strings covered with bound FVIII.

  10. Association between micro particle-tissue factor (show F3 Proteins) activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism.

Pig (Porcine) Coagulation Factor VIII (F8) interaction partners

  1. thrombin (show F2 Proteins) stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH Proteins) and by receptor-mediated up-regulation of factor XIII (show UGDH Proteins) synthesis

  2. cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant

Cow (Bovine) Coagulation Factor VIII (F8) interaction partners

  1. Factor VIIIc (show COX7A2 Proteins) is responsible for tissue invasion during tumor progression.

Factor VIII (F8) Protein Profile

Protein Summary

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Gene names and symbols associated with Coagulation Factor VIII Proteins (F8)

  • coagulation factor VIIi (f7i)
  • coagulation factor VIII (F8)
  • coagulation factor VIII, procoagulant component (F8)
  • AHF protein
  • Cf-8 protein
  • Cf8 protein
  • DXS1253E protein
  • F8B protein
  • F8C protein
  • fb61d02 protein
  • FVIII protein
  • HEMA protein
  • wu:fb61d02 protein

Protein level used designations for Coagulation Factor VIII Proteins (F8)

Factor VIII , procoagulant component , antihemophilic factor , coagulation factor VIII , coagulation factor VIIIc , factor VIII F8B , coagulation factor VIII, procoagulant component (hemophilia A) , factor VIII , coagulation co-factor

GENE ID SPECIES
282671 Danio rerio
14069 Mus musculus
2157 Homo sapiens
397339 Sus scrofa
403875 Canis lupus familiaris
100271720 Bos taurus
100303761 Oryctolagus cuniculus
302470 Rattus norvegicus
100359363 Ovis aries
422199 Gallus gallus
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