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anti-Coagulation Factor VIII (F8) Antibodies

F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. Additionally we are shipping Factor VIII Kits (55) and Factor VIII Proteins (32) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
F8 14069 Q06194
F8 2157 P00451
F8 302470  
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Top anti-Factor VIII Antibodies at antibodies-online.com

Showing 10 out of 336 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ELISA Detection limit for recombinant GST tagged F8 is approximately 3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Factor VIII antibody (S2194) [ABIN4493381] - in extracts from HuvEc cells. Immunocytochemistry/Immunofluorescence: Factor VIII Antibody [ABIN4493381] - Factor VIII antibody was tested 1:50 in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40x. 0.1 mg Log in to see 7 to 9 Days
$473.81
Details
Cow Rabbit Un-conjugated WB Host: Rabbit  Target Name: F8  Sample Tissue: 721_B Whole Cell  Lane A:  Primary Antibody Lane B:  Primary Antibody + Blocking Peptide Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 2 µg/mL Lysate Quantity: 241 µg/laneGel Concentration: 2.12 % 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat tibia tissue labeled with Anti-Factor VIII (FVIII) Polyclonal Antibody (ABIN668601) , Unconjugated at 1:300, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed : Mouse C57 cells labeled with Anti- Factor VIII (FVIII) Polyclonal Antibody (ABIN668601) , Unconjugated at 1:300, followed by conjugation to the secondary antibody was Goat Anti-Rabbit IgG, PE conjugated  at 1:200 for 40 minutes at 37 °C DAPI (5 µg/mL, blue) was used to stain the cell nuclei 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded human skin labeled with Anti-Factor VIII Polyclonal Antibody, Unconjugated (ABIN872493) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Dog Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$327.00
Details
Human Mouse Un-conjugated EIA, RIA, WB   0.5 mg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IF (cc), IF (p), IHC (p) Formalin-fixed and paraffin embedded:human colon carcinoma labeled with Anti-factor VIII(FVIII) (human) Polyclonal Antibody (ABIN728000), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded:human colon carcinoma labeled with Anti-factor VIII(FVIII)(human) Polyclonal Antibody , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Mouse Un-conjugated EIA, IHC (fro), WB   0.5 mg Log in to see 6 to 8 Days
$511.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$200.00
Details

F8 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Factor VIII Antibodies

  1. Human Monoclonal Factor VIII Primary Antibody for ELISA - ABIN394620 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN394620

  2. Dog (Canine) Polyclonal Factor VIII Primary Antibody for IF (p), IHC (p) - ABIN668601 : Yu, Zhang, Jiang, Wang, Zhang: Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. in Molecular medicine reports 2015 (PubMed)
    Show all 3 references for ABIN668601

  3. Human Polyclonal Factor VIII Primary Antibody for IF (cc), IF (p) - ABIN728000 : Zhou, Zhu, Zou, Wang: Changes in number and biological function of endothelial progenitor cells in hypertension disorder complicating pregnancy. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2008 (PubMed)
    Show all 2 references for ABIN728000

  4. Human Monoclonal Factor VIII Primary Antibody for ELISA, WB - ABIN969123 : Shovlin, Sulaiman, Govani, Jackson, Begbie: Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. in Thrombosis and haemostasis 2007 (PubMed)
    Show all 2 references for ABIN969123

  5. Human Monoclonal Factor VIII Primary Antibody for EIA, RIA - ABIN120341 : Rotblat, OBrien, OBrien, Goodall, Tuddenham: Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies. in Biochemistry 1985 (PubMed)
    Show all 2 references for ABIN120341

  6. Human Polyclonal Factor VIII Primary Antibody for IF (p), IHC (p) - ABIN872493 : Tang, Liu, Dong, Li, Li, Hou, Zheng, Lin, Ren: Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts. in Inflammation 2014 (PubMed)
    Show all 2 references for ABIN872493

  7. Human Polyclonal Factor VIII Primary Antibody for ICC, IF - ABIN449338 : Zhu, Liu, Miao, Qu, Chi: Enhanced plasma factor VIII activity in mice via cysteine mutation using dual vectors. in Science China. Life sciences 2012 (PubMed)
    Show all 2 references for ABIN449338

  8. Dog (Canine) Polyclonal Factor VIII Primary Antibody for IHC, ELISA - ABIN1582291 : Shen, Li, Chung, Gillies: Retinal vascular changes after glial disruption in rats. in Journal of neuroscience research 2010 (PubMed)

  9. Human Monoclonal Factor VIII Primary Antibody for EIA, IHC (fro) - ABIN112268 : Stel, van der Kwast, Veerman: Detection of factor VIII/coagulant antigen in human liver tissue. in Nature 1983 (PubMed)

More Antibodies against Factor VIII Interaction Partners

Zebrafish Coagulation Factor VIII (F8) interaction partners

  1. gene is flanked by factor VII (show TH Antibodies) and factor X genes; gene encodes a protein homologous to factor VII (show TH Antibodies), but lacks critical residues for factor VII (show TH Antibodies) activity; functions as an inhibitor of blood coagulation in biochemical assays using zebrafish or human plasmas

Mouse (Murine) Coagulation Factor VIII (F8) interaction partners

  1. the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (show VWF Antibodies) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.

  2. data demonstrate that infusion of platelets containing FVIII triggers neither primary nor memory anti-FVIII immune response in FVIII(null) mice

  3. Both platelet-VWF (show VWF Antibodies) and plasma-VWF (show VWF Antibodies) are required for optimal platelet-derived FVIII gene therapy for hemophilia A in the presence of inhibitors.

  4. These data support the investigation of FVIII orthologs as treatment modalities in both the congenital and acquired FVIII inhibitor settings.

  5. Activatable bioengineered FIX molecules with FVIII-independent activity might be a promising tool for improving hemophilia A treatment, especially for patients with inhibitors.

  6. This study demonstrated that FVIIIa interacts with Low-density lipoprotein receptor-related protein 1 (show LRP1 Antibodies) cluster III.

  7. a fragment containing only approximately 20% of the VWF (show VWF Antibodies) sequence is sufficient to support FVIII stability in vivo

  8. Endothelial cells from multiple, but not all, tissues contribute to the plasma FVIII pool in the mouse.

  9. Endothelial cells are the predominant, and possibly exclusive, source of plasma FVIII.

  10. Micro-computed tomography analysis of distal tibia metaphyses also revealed for the first time a major impact of the FVIII/thrombin (show F2 Antibodies)/PAR1 (show F2R Antibodies) axis on the dynamic bone structure, showing reduced bone.

Human Coagulation Factor VIII (F8) interaction partners

  1. the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (show VWF Antibodies) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.

  2. Our finding that the C2-domain of FVIII can be replaced by that of FV without compromising FVIII activity may have translational implications.

  3. Galectin-1 (show LGALS1 Antibodies) and Galectin-3 (show LGALS3 Antibodies) are novel-binding partners for human FVIII. Gal-1 (show LGALS1 Antibodies) binding can influence the procoagulant activity of FVIII.

  4. although fVIII bound avidly to soluble forms of clusters II and IV from LRP1 (show LRP1 Antibodies), only soluble cluster IV competed with the binding of fVIII to full-length LRP1 (show LRP1 Antibodies), revealing that cluster IV represents the major fVIII binding site in LRP1 (show LRP1 Antibodies).

  5. The FVIII B domain variants, p.D963N, p.S806T, p.G873D, p.H998Q and p.Q1225R may be considered as polymorphism or non-pathologic mutations in patients with Haemophilia A.

  6. In this meta-analysis, we have assessed the association between the FXIII-A Val34Leu polymorphism and intracerebral hemorrhage risk. The results of a combined analysis showed no significant association between the FXIII-A Val34Leu polymorphism and ICH (show COL4a2 Antibodies) risk in the overall population. The results of this meta-analysis suggest that the FXIII-A Val34Leu polymorphism is not associated with ICH (show COL4a2 Antibodies) risk in a Caucasian population.

  7. von Willebrand factor (show VWF Antibodies) binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.

  8. Desmopressin acetate increases F8 plasma concentration in patients with combined deficiency of factors V and VIII (show COX8A Antibodies).

  9. 37 (70%) of the 53 had discordant antigen-activity ratio, majority of those mutations produced FVIII with low FVIII-specific activity. However, 4 (7.5%) of the 53 mutations produced higher specific activity of FVIII. It is possible that these mutations either produce a secretory defect or an increased metabolic turnover to account for the low levels of FVIII with these mutations.

  10. Platelet-targeted FVIII gene therapy has higher therapeutic efficacy compared to factor VIII replacement therapy may be due to accelerated thrombin (show F2 Antibodies) generation.

Pig (Porcine) Coagulation Factor VIII (F8) interaction partners

  1. thrombin (show F2 Antibodies) stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (show UGDH Antibodies) and by receptor-mediated up-regulation of factor XIII (show UGDH Antibodies) synthesis

  2. cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant

Cow (Bovine) Coagulation Factor VIII (F8) interaction partners

  1. Factor VIIIc (show COX7A2 Antibodies) is responsible for tissue invasion during tumor progression.

Factor VIII (F8) Antigen Profile

Protein Summary

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Gene names and symbols associated with F8

  • coagulation factor VIIi (f7i) antibody
  • coagulation factor VIII (F8) antibody
  • coagulation factor VIII, procoagulant component (F8) antibody
  • AHF antibody
  • Cf-8 antibody
  • Cf8 antibody
  • DXS1253E antibody
  • F8B antibody
  • F8C antibody
  • fb61d02 antibody
  • FVIII antibody
  • HEMA antibody
  • wu:fb61d02 antibody

Protein level used designations for F8

Factor VIII , procoagulant component , antihemophilic factor , coagulation factor VIII , coagulation factor VIIIc , factor VIII F8B , coagulation factor VIII, procoagulant component (hemophilia A) , factor VIII , coagulation co-factor

GENE ID SPECIES
282671 Danio rerio
14069 Mus musculus
2157 Homo sapiens
397339 Sus scrofa
403875 Canis lupus familiaris
100271720 Bos taurus
100303761 Oryctolagus cuniculus
302470 Rattus norvegicus
100359363 Ovis aries
422199 Gallus gallus
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