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F8A1 is contained entirely within intron 22 of the factor VIII gene; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. Additionally we are shipping and many more products for this protein.
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Orientations for FVIIIa are identified that bind to the membrane surface and support a new interaction between the A3 domain and the membrane, probably mediated in part by Arg(1719) and Arg(1721)
The mutation Arg489Ala/Arg490Ala/Lys493Ala (489-3A) possessed near-normal affinity for FIXa (show ETFB Antibodies) and showed no effect on the Km for Factor X.
cupredoxin-like A1 subdomains in fVIII (show F8 Antibodies) contain inter-species differences that are a result of selective pressure on the dissociation rate constant
Protein S enhances the tissue factor pathway inhibitor (show TFPI Antibodies) inhibition of factor Xa (show F10 Antibodies) but not its inhibition of factor VIIa-tissue factor (show F3 Antibodies)
This gene is contained entirely within intron 22 of the factor VIII gene\; spans less than 2 kb, and is transcribed in the direction opposite of factor VIII. A portion of intron 22 (int22h), containing F8A, is repeated twice extragenically closer to the Xq telomere. Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types.
coagulation factor VIII-associated (intronic transcript) 1
, factor 8-associated gene A
, factor VIII intron 22 protein
, huntingtin-associated protein 40
, coagulation factor 8-associated (intronic transcript) 3
, coagulation factor VIII-associated 3
, cpG island protein
, factor VIII associated protein