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F11 encodes coagulation factor XI of the blood coagulation cascade. Additionally we are shipping Factor XI Antibodies (64) and Factor XI Proteins (15) and many more products for this protein.
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Factor XI and factor XII (show F12 ELISA Kits) activities were significantly higher in patients with slow coronary flow than in controls, and could be associated with enhanced procoagulant state present in these patients.
FXI-thrombin (show F2 ELISA Kits) axis contributes to distal platelet activation and procoagulant microaggregate formation in the blood flow downstream of the site of thrombus formation.
F11 gene variant rs2289252 contributes to inherited forms of deep vein thrombosis incidence in Latvian population.
ROTEM assays failed to distinguish bleeding from non-bleeding patients but could do so between different FXI activity levels and genotypes.
increased activity of FXI may be a potential risk factor for miscarriage; high activity of FXI diagnosed in women with history of miscarriage is not probably caused by the presence of SNPs rs2289252 and rs2036914
Data indicate that the mean factor XI (FXI) was not significantly different in laboratories using the same method on both exercises, suggesting good intralaboratory precision over time.
Identification of a novel c.290G>A mutation in the F11 gene that is associated with mild Factor XI deficiency in a Dutch Caucasian family.
In whites, the FXI variant was associated with both factor XI concentration and venous thromboembolism (VTE) incidence (1.15-fold greater incidence of VTE per risk allele), whereas In African-Americans, these associations were absent.
Polyphosphate greatly accelerates factor V activation by factor XIa, and that this is supported by polyphosphate polymers of the size secreted by activated human platelets.
Contribution of FXIa and platelet-derived polyphosphate in thrombin (show F2 ELISA Kits) generation varies depending on surface tissue-factor (show F3 ELISA Kits) level.
Thrombin (show F2 ELISA Kits)-independent contribution of tissue factor (show F3 ELISA Kits) to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
FXI deprivation was shown to slow down atherogenesis in Apoe (show APOE ELISA Kits) knockout mice.
anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin (show SERPINC1 ELISA Kits) are also required for expression of polyP cofactor activity during FXI activation
Data conclude that within the mouse F11, Klkb1 (show KLKB1 ELISA Kits), Cyp4v3 (show CYP4V2 ELISA Kits) gene cluster, F11 and Cyp4v3 (show CYP4V2 ELISA Kits) frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements.
Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis.
Protective roles for fibrin, tissue factor (show F3 ELISA Kits), plasminogen activator inhibitor-1 (show SERPINE1 ELISA Kits), and thrombin activatable fibrinolysis inhibitor (show CPB2 ELISA Kits), but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.
fXI and fXII (show F12 ELISA Kits) contribute to thrombus formation even when factor VIIa/tissue factor (show F3 ELISA Kits) initiates thrombosis.
Gene targeting of tissue factor (show F3 ELISA Kits), factor X, and factor VII (show TH ELISA Kits) in mice: their involvement in embryonic development
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse.
FIX and FXI deficiency cause similar effects in the carotid artery injury model
Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.
Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.
The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
coagulation factor XI (plasma thromboplastin antecedent)
, platelet coagulation factor XI
, coagulation factor XI
, coagulation factor XI-like
, plasma thromboplastin antecedent
, factor XI
, blood coagulation factor XI