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Coagulation Factor XI Proteins (F11)

F11 encodes coagulation factor XI of the blood coagulation cascade. Additionally we are shipping Factor XI Antibodies (68) and Factor XI Kits (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F11 2160 P03951
F11 109821 Q91Y47
F11 290757  
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Top Factor XI Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$547.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$759.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$880.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,010.33
Details
Yeast Mouse His tag   1 mg Log in to see 56 to 66 Days
$3,017.67
Details
HOST_Human Human Un-conjugated   0.1 mg Log in to see 2 to 3 Days
$242.00
Details

F11 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced Factor XI Proteins

  1. Human Factor XI Protein expressed in Human Cells - ABIN3216382 : Meijers, Davie, Chung: Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency. in Blood 1992 (PubMed)

More Proteins for Coagulation Factor XI (F11) Interaction Partners

Human Coagulation Factor XI (F11) interaction partners

  1. the co-localization of thrombin (show F2 Proteins) and factor XI and the resultant efficient activation of FXI requires GPIb alpha (show GP1BA Proteins)

  2. factor XI is localized to GPIb in membrane rafts and that this association is important for promoting the activation of factor XI by thrombin (show F2 Proteins) on the platelet surface

  3. Factor XI and factor XII (show F12 Proteins) activities were significantly higher in patients with slow coronary flow than in controls, and could be associated with enhanced procoagulant state present in these patients.

  4. FXI-thrombin (show F2 Proteins) axis contributes to distal platelet activation and procoagulant microaggregate formation in the blood flow downstream of the site of thrombus formation.

  5. F11 gene variant rs2289252 contributes to inherited forms of deep vein thrombosis incidence in Latvian population.

  6. ROTEM assays failed to distinguish bleeding from non-bleeding patients but could do so between different FXI activity levels and genotypes.

  7. increased activity of FXI may be a potential risk factor for miscarriage; high activity of FXI diagnosed in women with history of miscarriage is not probably caused by the presence of SNPs rs2289252 and rs2036914

  8. Data indicate that the mean factor XI (FXI) was not significantly different in laboratories using the same method on both exercises, suggesting good intralaboratory precision over time.

  9. Identification of a novel c.290G>A mutation in the F11 gene that is associated with mild Factor XI deficiency in a Dutch Caucasian family.

  10. In whites, the FXI variant was associated with both factor XI concentration and venous thromboembolism (VTE) incidence (1.15-fold greater incidence of VTE per risk allele), whereas In African-Americans, these associations were absent.

Mouse (Murine) Coagulation Factor XI (F11) interaction partners

  1. Thrombin (show F2 Proteins)-independent contribution of tissue factor (show F3 Proteins) to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

  2. FXI deprivation was shown to slow down atherogenesis in Apoe (show APOE Proteins) knockout mice.

  3. anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin (show SERPINC1 Proteins) are also required for expression of polyP cofactor activity during FXI activation

  4. Data conclude that within the mouse F11, Klkb1 (show KLKB1 Proteins), Cyp4v3 (show CYP4V2 Proteins) gene cluster, F11 and Cyp4v3 (show CYP4V2 Proteins) frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements.

  5. Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis.

  6. Protective roles for fibrin, tissue factor (show F3 Proteins), plasminogen activator inhibitor-1 (show SERPINE1 Proteins), and thrombin activatable fibrinolysis inhibitor (show CPB2 Proteins), but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.

  7. fXI and fXII (show F12 Proteins) contribute to thrombus formation even when factor VIIa/tissue factor (show F3 Proteins) initiates thrombosis.

  8. Gene targeting of tissue factor (show F3 Proteins), factor X, and factor VII (show TH Proteins) in mice: their involvement in embryonic development

  9. FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse.

  10. FIX and FXI deficiency cause similar effects in the carotid artery injury model

Cow (Bovine) Coagulation Factor XI (F11) interaction partners

  1. Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.

  2. Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.

  3. The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene

Factor XI (F11) Protein Profile

Protein Summary

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

Gene names and symbols associated with Coagulation Factor XI Proteins (F11)

  • coagulation factor XI (F11)
  • coagulation factor XI (CpipJ_CPIJ000593)
  • coagulation factor XI (CpipJ_CPIJ001060)
  • coagulation factor XI (CpipJ_CPIJ002752)
  • coagulation factor XI (CpipJ_CPIJ003631)
  • coagulation factor XI (CpipJ_CPIJ004041)
  • coagulation factor XI (CpipJ_CPIJ004093)
  • 1600027G01Rik protein
  • AI503996 protein
  • Cf11 protein
  • FXI protein
  • LRRGT00086 protein

Protein level used designations for Coagulation Factor XI Proteins (F11)

coagulation factor XI (plasma thromboplastin antecedent) , platelet coagulation factor XI , coagulation factor XI , coagulation factor XI-like , PTA , plasma thromboplastin antecedent , factor XI , blood coagulation factor XI

GENE ID SPECIES
461643 Pan troglodytes
6031603 Culex quinquefasciatus
6032063 Culex quinquefasciatus
6033946 Culex quinquefasciatus
6035180 Culex quinquefasciatus
6035438 Culex quinquefasciatus
6035567 Culex quinquefasciatus
100443368 Pongo abelii
100468102 Ailuropoda melanoleuca
100594390 Nomascus leucogenys
2160 Homo sapiens
109821 Mus musculus
290757 Rattus norvegicus
100009596 Oryctolagus cuniculus
100715511 Cavia porcellus
407998 Bos taurus
475623 Canis lupus familiaris
422723 Gallus gallus
101116630 Ovis aries
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