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F11 encodes coagulation factor XI of the blood coagulation cascade. Additionally we are shipping Factor XI Antibodies (69) and Factor XI Kits (35) and many more products for this protein.
Showing 10 out of 15 products:
Human Factor XI Protein expressed in Human Cells - ABIN3216382
Meijers, Davie, Chung: Expression of human blood coagulation factor XI: characterization of the defect in factor XI type III deficiency. in Blood 1992
F11 genetic variants are associated with the risk of incident venous thrombosis among women
This study characterized FXI deficiency mutation spectrum in Chinese population with a high frequency of the W228*, G400V, Q263* and c.1136-4delGTTG mutations, which is distinct from that of other populations including Korean, Jewish or European populations.
F5 rs6025 and F11 rs2289252 contributed to the risk of recurrent venous thromboembolism and the combination is of potential clinical relevance for risk prediction
the co-localization of thrombin (show F2 Proteins) and factor XI and the resultant efficient activation of FXI requires GPIb alpha (show GP1BA Proteins)
factor XI is localized to GPIb in membrane rafts and that this association is important for promoting the activation of factor XI by thrombin (show F2 Proteins) on the platelet surface
Factor XI and factor XII (show F12 Proteins) activities were significantly higher in patients with slow coronary flow than in controls, and could be associated with enhanced procoagulant state present in these patients.
FXI-thrombin (show F2 Proteins) axis contributes to distal platelet activation and procoagulant microaggregate formation in the blood flow downstream of the site of thrombus formation.
F11 gene variant rs2289252 contributes to inherited forms of deep vein thrombosis incidence in Latvian population.
ROTEM assays failed to distinguish bleeding from non-bleeding patients but could do so between different FXI activity levels and genotypes.
increased activity of FXI may be a potential risk factor for miscarriage; high activity of FXI diagnosed in women with history of miscarriage is not probably caused by the presence of SNPs rs2289252 and rs2036914
Thrombin (show F2 Proteins)-independent contribution of tissue factor (show F3 Proteins) to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
FXI deprivation was shown to slow down atherogenesis in Apoe (show APOE Proteins) knockout mice.
anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin (show SERPINC1 Proteins) are also required for expression of polyP cofactor activity during FXI activation
Data conclude that within the mouse F11, Klkb1 (show KLKB1 Proteins), Cyp4v3 (show CYP4V2 Proteins) gene cluster, F11 and Cyp4v3 (show CYP4V2 Proteins) frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements.
Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis.
Protective roles for fibrin, tissue factor (show F3 Proteins), plasminogen activator inhibitor-1 (show SERPINE1 Proteins), and thrombin activatable fibrinolysis inhibitor (show CPB2 Proteins), but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.
fXI and fXII (show F12 Proteins) contribute to thrombus formation even when factor VIIa/tissue factor (show F3 Proteins) initiates thrombosis.
Gene targeting of tissue factor (show F3 Proteins), factor X, and factor VII (show TH Proteins) in mice: their involvement in embryonic development
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse.
FIX and FXI deficiency cause similar effects in the carotid artery injury model
Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.
Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.
The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
coagulation factor XI (plasma thromboplastin antecedent)
, platelet coagulation factor XI
, coagulation factor XI
, coagulation factor XI-like
, plasma thromboplastin antecedent
, factor XI
, blood coagulation factor XI