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F12 Proteins

(Coagulation Factor XII (F12))

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].

recommended

F12 Protein (AA 1-300) (GST tag) (ABIN1353299)

F12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

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recommended

F12 Protein (AA 191-300) (GST tag) (ABIN1353303)

F12 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP

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recommended

F12 Protein (AA 20-372) (His tag) (ABIN3079847)

Crystallography grade F12 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

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F12 Proteins by Grade

Find F12 Proteins with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

F12 Proteins by Origin

Find F12 Proteins for a variety of species such as anti-Human F12, anti-Mouse F12, anti-Cow F12. The species listed below are among those available. Click on a link to go to the corresponding products.

F12 Proteins by Source

Here you will find F12 Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

F12 Proteins by Protein Type

Here you can find F12 Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

F12 Proteins by Application

Find F12 Proteins validated for a specific application such as ELISA, WB, SDS, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular F12 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

F12 Protein (AA 1-300) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1353299

Quantity 10 μg

Datasheet Datasheet

F12 Protein (AA 191-300) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1353303

Quantity 10 μg

Datasheet Datasheet

F12 Protein (AA 20-372) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3079847

Quantity 1 mg

Datasheet Datasheet

F12 Protein (AA 373-615) (His tag)

Reactivity Human

Source Insect Cells

Validations

Cat. No. ABIN3079848

Quantity 1 mg

Datasheet Datasheet

F12 Protein (AA 20-354) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3124453

Quantity 1 mg

Datasheet Datasheet

F12 Protein (AA 355-597) (His tag)

Reactivity Mouse

Source Insect Cells

Validations

Cat. No. ABIN3124454

Quantity 1 mg

Datasheet Datasheet

F12 Protein (AA 352-587) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7391612

Quantity 100 μg

Datasheet Datasheet

F12 Protein (AA 400-615) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7391609

Quantity 100 μg

Datasheet Datasheet

F12 Protein

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN3008873

Quantity 100 μg

Datasheet Datasheet

F12 Protein (AA 20-371) (His tag)

Reactivity Pig

Source Yeast

Validations

Cat. No. ABIN7479001

Quantity 100 μg

Datasheet Datasheet

F12 Protein (AA 20-353) (His tag)

Reactivity Rat

Source Yeast

Validations

Cat. No. ABIN1475408

Quantity 1 mg

Datasheet Datasheet

F12 Protein (AA 20-368) (His tag)

Reactivity Cow

Source Yeast

Validations

Cat. No. ABIN1459540

Quantity 1 mg

Datasheet Datasheet

Latest Publications for our F12 Proteins

Baeriswyl, Calzavarini, Chen, Zorzi, Bologna, Angelillo-Scherrer, Heinis: "A Synthetic Factor XIIa Inhibitor Blocks Selectively Intrinsic Coagulation Initiation." in: ACS chemical biology, Vol. 10, Issue 8, pp. 1861-70, (2015) (PubMed).

Rentero Rebollo, Sabisz, Baeriswyl, Heinis: "Identification of target-binding peptide motifs by high-throughput sequencing of phage-selected peptides." in: Nucleic acids research, Vol. 42, Issue 22, pp. e169, (2014) (PubMed).

Aliases for F12 Proteins

coagulation factor XII (F12) Proteins
coagulation factor XII (Hageman factor) (F12) Proteins
FXII Proteins
HAE3 Proteins
HAEX Proteins
HAF Proteins

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F12 Proteins by Grade

F12 Proteins by Origin

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Popular F12 Proteins

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Aliases for F12 Proteins

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