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F13B encodes coagulation factor XIII B subunit.
These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations.
The results suggest that plasma FXIII levels are subjected to multifactorial regulation with age, fibrinogen level and FXIII-B intron K polymorphism being the major determinants. Their effect on FXIII levels might influence the risk of thrombotic diseases.
Genetic markers associated with low FXIIIB levels increase risk of ischemic stroke cardioembolic subtype.
The FXIII-B intron K nt29756 G allele was associated with significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile.
Changes in plasma levels of FXIIIB are associated with cognitive decline in the elderly.
Here, we update the knowledge about the pathophysiology of factor XIII (show UGDH Antibodies) deficiency and its therapeutic options. [review]
Data suggest that Factor XIII (show UGDH Antibodies) (composed of subunits F13A (show F13A1 Antibodies) and F13B) increases rigidity/strength of fibrin clot (show TXNDC17 Antibodies), protects fibrin clot (show TXNDC17 Antibodies) against shear stress in circulation, and protects fibrin from prompt elimination by fibrinolytic system. [REVIEW]
Factor XIII (show UGDH Antibodies) levels are decreased in Crohn's disease patients, but did not correlate with the time course of disease evolution, CRP (show CRP Antibodies), serum fibrin levels, platelet count, disease distribution within the bowel, or the presence of a fistulising form.
A review analyzes and present an exhaustive amount of F13B mutational data from the past three decades.
FXIIIb subunit is found to be within normal range in eight Tunisian famillies with congenital factor XIII (show UGDH Antibodies) deficiency caused by two mutations, while expression of the FXIIIA subunit gene is decreased or undetectable.
Physiological significance of mouse TG2 (show TGM2 Antibodies) and Factor XIII (show UGDH Antibodies) through identification of substrate proteins in MC3T3-E1 cells.
This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits\; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
, coagulation factor XIII B chain
, fibrin-stabilizing factor B subunit
, protein-glutamine gamma-glutamyltransferase B chain
, transglutaminase B chain
, coagulation factor XIII, beta subunit