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Cofactor of BRCA1 (COBRA1) ELISA Kits

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). Additionally we are shipping COBRA1 Antibodies (57) and COBRA1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human COBRA1 COBRA1 25920 Q8WX92
Anti-Rat COBRA1 COBRA1 311796  
Anti-Mouse COBRA1 COBRA1 58202 Q8C4Y3
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More ELISA Kits for COBRA1 Interaction Partners

Human Cofactor of BRCA1 (COBRA1) interaction partners

  1. both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG.

  2. These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A (show WHSC2 ELISA Kits) and NELF-B, relative to other factors in the overall gene induction sequence.

  3. data show that NELF (show NELF ELISA Kits) subunits exhibit highly specific subcellular localizations, such as in NELF (show NELF ELISA Kits) bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF (show NELF ELISA Kits) from cells can lead to enlarged and/or multiple nuclei

  4. NELF-C (show TH1L ELISA Kits) and NELF-D (show TH1L ELISA Kits) are highly related or identical to the protein called TH1 (show TH1L ELISA Kits), of unknown function. NELF-B and NELF-C (show TH1L ELISA Kits) or NELF-D (show TH1L ELISA Kits) are integral subunits that bring NELF-A (show WHSC2 ELISA Kits) and NELF-E (show RDBP ELISA Kits) together. [NELF-B] [NELF-C (show TH1L ELISA Kits)]

  5. COBRA1 may directly modulate AP-1 (show FOSB ELISA Kits) pathway and, therefore, may play important roles in cell proliferation, differentiation, apoptosis, and oncogenesis.

  6. COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines.

  7. Decreasing NELF also correlated with displacement of a positioned nucleosome and increased acetylation of histone H4, suggesting coupling of transcription elongation and chromatin remodeling

  8. Negative elongation factor (NELF (show RDBP ELISA Kits)) is a four subunit transcription factor. Our results point to a surprising role of NELF (show NELF ELISA Kits) in the 3' end processing of histone mRNAs and suggest that NELF (show NELF ELISA Kits) is a new factor that coordinates mRNA processing in transcription.

  9. COBRA1 may coordinate multiple steps in ligand-dependent gene expression, which in turn ensures both the quantity and quality of hormone-stimulated gene products

  10. a lack of COBRA1 expression in breast carcinoma may serve as a useful indicator for poor prognosis.

Mouse (Murine) Cofactor of BRCA1 (COBRA1) interaction partners

  1. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 (show BRCA1 ELISA Kits) in antagonizing COBRA1-dependent transcription program during mammary gland development.

  2. Human and mouse Nelfb encode proteins translated from a non-AUG (CUG) start codon. The majority of mouse tissues examined express the isoform translated from the CUG start codon, but a small number of tissues also express a shorter isoform of the same apparent size as the AUG-initiated isoform.

  3. Cobra1 Is Required for TrkC (show NTRK3 ELISA Kits)-Induced Apoptosis.

  4. genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing.

  5. findings also indicate that Cobra1 helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes

COBRA1 Antigen Profile

Antigen Summary

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1\; MIM 603555) and SPT5 (SUPT5H\; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003

Gene names and symbols associated with Cofactor of BRCA1 (COBRA1) ELISA Kits

  • cofactor of BRCA1 (LOC100219583) antibody
  • cofactor of BRCA1 (COBRA1) antibody
  • negative elongation factor complex member B (NELFB) antibody
  • negative elongation factor complex member B (nelfb) antibody
  • cofactor of BRCA1 (cobra1) antibody
  • negative elongation factor complex member B (Nelfb) antibody
  • negative elongation factor complex member B, Cobra1 (Nelfb) antibody
  • A730008L03Rik antibody
  • AB041607 antibody
  • AI663983 antibody
  • bZ1O1.4 antibody
  • Cobra1 antibody
  • cobra2 antibody
  • fe01e12 antibody
  • LOC100219583 antibody
  • MGC131073 antibody
  • Nelf-b antibody
  • RGD1307832 antibody
  • wu:fe01e12 antibody
  • zgc:55628 antibody

Protein level used designations for Cofactor of BRCA1 (COBRA1) ELISA Kits

cofactor of BRCA1 , negative elongation factor B , negative elongation factor B-like , negative elongation factor protein B , ortholog of human cofactor of BRCA1 (COBRA1)

GENE ID SPECIES
100219583 Taeniopygia guttata
736409 Pan troglodytes
512799 Bos taurus
417254 Gallus gallus
393137 Danio rerio
704966 Macaca mulatta
491230 Canis lupus familiaris
496936 Xenopus (Silurana) tropicalis
734938 Xenopus laevis
100438513 Pongo abelii
100469627 Ailuropoda melanoleuca
100514560 Sus scrofa
100538856 Meleagris gallopavo
100560093 Anolis carolinensis
101103711 Ovis aries
25920 Homo sapiens
311796 Rattus norvegicus
58202 Mus musculus
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