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Cofactor of BRCA1 Proteins (COBRA1)

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). Additionally we are shipping COBRA1 Antibodies (54) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COBRA1 25920 Q8WX92
Rat COBRA1 COBRA1 311796  
Mouse COBRA1 COBRA1 58202 Q8C4Y3
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Top COBRA1 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human GST tag Cofactor of BRCA1 (COBRA1) (AA 8-199), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

COBRA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

Top referenced COBRA1 Proteins

  1. Human COBRA1 Protein expressed in Escherichia coli (E. coli) - ABIN1047452 : Ye, Hu, Zhong, Nye, Belmont, Li: BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. in The Journal of cell biology 2001 (PubMed)

More Proteins for Cofactor of BRCA1 (COBRA1) Interaction Partners

Human Cofactor of BRCA1 (COBRA1) interaction partners

  1. both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG.

  2. These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A (show WHSC2 Proteins) and NELF-B, relative to other factors in the overall gene induction sequence.

  3. data show that NELF (show NELF Proteins) subunits exhibit highly specific subcellular localizations, such as in NELF (show NELF Proteins) bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF (show NELF Proteins) from cells can lead to enlarged and/or multiple nuclei

  4. NELF-C (show TH1L Proteins) and NELF-D (show TH1L Proteins) are highly related or identical to the protein called TH1 (show TH1L Proteins), of unknown function. NELF-B and NELF-C (show TH1L Proteins) or NELF-D (show TH1L Proteins) are integral subunits that bring NELF-A (show WHSC2 Proteins) and NELF-E (show RDBP Proteins) together. [NELF-B] [NELF-C (show TH1L Proteins)]

  5. COBRA1 may directly modulate AP-1 (show FOSB Proteins) pathway and, therefore, may play important roles in cell proliferation, differentiation, apoptosis, and oncogenesis.

  6. COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines.

  7. Decreasing NELF also correlated with displacement of a positioned nucleosome and increased acetylation of histone H4, suggesting coupling of transcription elongation and chromatin remodeling

  8. Negative elongation factor (NELF (show RDBP Proteins)) is a four subunit transcription factor. Our results point to a surprising role of NELF (show NELF Proteins) in the 3' end processing of histone mRNAs and suggest that NELF (show NELF Proteins) is a new factor that coordinates mRNA processing in transcription.

  9. COBRA1 may coordinate multiple steps in ligand-dependent gene expression, which in turn ensures both the quantity and quality of hormone-stimulated gene products

  10. a lack of COBRA1 expression in breast carcinoma may serve as a useful indicator for poor prognosis.

Mouse (Murine) Cofactor of BRCA1 (COBRA1) interaction partners

  1. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 (show BRCA1 Proteins) in antagonizing COBRA1-dependent transcription program during mammary gland development.

  2. Human and mouse Nelfb encode proteins translated from a non-AUG (CUG) start codon. The majority of mouse tissues examined express the isoform translated from the CUG start codon, but a small number of tissues also express a shorter isoform of the same apparent size as the AUG-initiated isoform.

  3. Cobra1 Is Required for TrkC (show NTRK3 Proteins)-Induced Apoptosis.

  4. genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing.

  5. findings also indicate that Cobra1 helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes

COBRA1 Protein Profile

Protein Summary

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1\; MIM 603555) and SPT5 (SUPT5H\; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003

Gene names and symbols associated with Cofactor of BRCA1 Proteins (COBRA1)

  • cofactor of BRCA1 (LOC100219583)
  • cofactor of BRCA1 (COBRA1)
  • negative elongation factor complex member B (NELFB)
  • negative elongation factor complex member B (nelfb)
  • cofactor of BRCA1 (cobra1)
  • negative elongation factor complex member B (Nelfb)
  • negative elongation factor complex member B, Cobra1 (Nelfb)
  • A730008L03Rik protein
  • AB041607 protein
  • AI663983 protein
  • bZ1O1.4 protein
  • Cobra1 protein
  • cobra2 protein
  • fe01e12 protein
  • LOC100219583 protein
  • MGC131073 protein
  • Nelf-b protein
  • RGD1307832 protein
  • wu:fe01e12 protein
  • zgc:55628 protein

Protein level used designations for Cofactor of BRCA1 Proteins (COBRA1)

cofactor of BRCA1 , negative elongation factor B , negative elongation factor B-like , negative elongation factor protein B , ortholog of human cofactor of BRCA1 (COBRA1)

100219583 Taeniopygia guttata
736409 Pan troglodytes
512799 Bos taurus
417254 Gallus gallus
393137 Danio rerio
704966 Macaca mulatta
491230 Canis lupus familiaris
496936 Xenopus (Silurana) tropicalis
734938 Xenopus laevis
100438513 Pongo abelii
100469627 Ailuropoda melanoleuca
100514560 Sus scrofa
100538856 Meleagris gallopavo
100560093 Anolis carolinensis
101103711 Ovis aries
25920 Homo sapiens
311796 Rattus norvegicus
58202 Mus musculus
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