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The protein encoded by CFL1/2 can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner.
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Human Polyclonal CFL1/2 Primary Antibody for IF, IHC - ABIN363074
Chen, Cizeau, Vande Velde, Park, Bozek, Bolton, Shi, Dubik, Greenberg: Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. in The Journal of biological chemistry 1999
Show all 4 references for ABIN363074
Human Polyclonal CFL1/2 Primary Antibody for IHC - ABIN362442
Arber, Barbayannis, Hanser, Schneider, Stanyon, Bernard, Caroni: Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. in Nature 1998
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These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (show VPS72 Antibodies) in U251 human glioma cells.
The present findings demonstrated that the anticancer effect of docetaxel induces the apoptosis of prostate cancer via the suppression of the cofilin1 and paxillin (show PXN Antibodies) signaling pathways, which will assist in setting a stage for the clinical treatment of prostate cancer.
VEGFA (show VEGFA Antibodies) induced phosphorylation of Pak1 (show PAK1 Antibodies) and its effector cofilin (show CFL1 Antibodies) in a manner that was dependent on time as well as p38MAPKbeta.
CFL1 (show VPS72 Antibodies) itself does not translocate actin into the cell nucleus but this transport requires the functional expression of IPO9 (show IPO9 Antibodies).
Abnormal CFL1 (show VPS72 Antibodies) expression may affect vulvar carcinogenesis and subsequent progression.
PAK1 (show PAK1 Antibodies)-cofilin (show CFL1 Antibodies) phosphorylation mechanism to mediate lung adenocarcinoma cells migration promoted by apelin (show APLN Antibodies)-13
Progesterone (P4) increases human astrocytoma cells migration and invasion through its intracellular receptor, and that cofilin (show CFL1 Antibodies) activation by P4 is independent of progesterone receptor (show PGR Antibodies) action.
the presence of the actin-severing protein, cofilin (show CFL1 Antibodies), in human sperm, is reported.
Aurora kinase A (show AURKA Antibodies) has a role in inducing papillary thyroid cancer lymph node metastasis by promoting cofilin-1 (show CFL1 Antibodies) activity
analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.
18 kDa phosphoprotein
, cofilin, non-muscle isoform