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CCDC50 encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Additionally we are shipping Coiled-Coil Domain Containing 50 Antibodies (83) and Coiled-Coil Domain Containing 50 Kits (12) and many more products for this protein.
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Ymer acts as a regulator downstream of several receptors and that Ymer functions as a positive or negative regulator in a signaling pathway-dependent manner.
identification of a novel DFNA locus on chromosome 3q28-29 in a Spanish family with postlingual and progressive hearing loss[DFNA44]
Ymer functions as a novel inhibitor for the down-regulation of the EGF receptor (show EGFR Proteins) and plays a crucial role for regulating the amount of the EGF receptor (show EGFR Proteins) on the cell surface membrane
These findings demonstrate that Ymer is likely to be a negative regulator for the NF-kappaB (show NFKB1 Proteins) signaling pathway.
CCDC50 is required for survival in mantle cell lymphoma and chronic lymphocytic leukemia cells and controls NFkappaB signaling
This gene encodes a soluble, cytoplasmic, tyrosine-phosphorylated protein with multiple ubiquitin-interacting domains. Mutations in this gene cause nonsyndromic, postlingual, progressive sensorineural DFNA44 hearing loss. In mouse, the protein is expressed in the inner ear during development and postnatal maturation and associates with microtubule-based structures. This protein may also function as a negative regulator of NF-kB signaling and as an effector of epidermal growth factor (EGF)-mediated cell signaling. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
coiled-coil domain containing 50
, Ymer protein
, coiled-coil domain-containing protein 50
, protein Ymer
, putative C3orf6 protein homolog