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CCDC6 encodes a coiled-coil domain-containing protein. Additionally we are shipping CCDC6 Antibodies (56) and many more products for this protein.
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Human CCDC6 Protein expressed in Wheat germ - ABIN1348309
Luise, Merolla, Leone, Paladino, Sarnataro, Fusco, Celetti: Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity. in PLoS ONE 2012
we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications
Results show that RNA-binding protein EWS (show EWSR1 Proteins) binds and regulates CCDC6 expression at RNA and protein levels.
CCDC6 levels provide valuable insight for OS.
the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.
Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing.
CCDC6 is associated with cAMP signaling by fine regulating CREB1 (show CREB1 Proteins) transcriptional activity in normal and transformed thyroid cells.
CCDC6-RET (show RET Proteins) fusion is associated with lung adenocarcinoma.
It was shown that FBXW7 (show FBXW7 Proteins) interacts with and targets CCDC6 for ubiquitin-mediated proteasomal degradation. FBXW7 (show FBXW7 Proteins)-mediated CCDC6 degradation was impaired in response to DNA damage.
Following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry.
CCDC6 plays a key role in cell cycle control.
Ccdc6-ex2 knock-in mice developed thyroid hyperplasia associated with an enhanced CREB1 (show CREB1 Proteins) activity and an increased expression of the CREB-1 (show CREB1 Proteins) regulated genes.
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.
coiled-coil domain-containing protein 6
, coiled-coil domain containing 6
, papillary thyroid carcinoma-encoded protein