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Coiled-Coil Domain Containing 6 Proteins (CCDC6)

CCDC6 encodes a coiled-coil domain-containing protein. Additionally we are shipping CCDC6 Antibodies (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CCDC6 8030 Q16204
CCDC6 76551 D3YZP9
Rat CCDC6 CCDC6 691155  
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Top CCDC6 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details

CCDC6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Top referenced CCDC6 Proteins

  1. Human CCDC6 Protein expressed in Wheat germ - ABIN1348309 : Luise, Merolla, Leone, Paladino, Sarnataro, Fusco, Celetti: Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity. in PLoS ONE 2012 (PubMed)

More Proteins for Coiled-Coil Domain Containing 6 (CCDC6) Interaction Partners

Human Coiled-Coil Domain Containing 6 (CCDC6) interaction partners

  1. we propose that the amount of CCDC6 protein in primary tumors, as reported in lung, may depend on the impairment of the CCDC6 turnover due to altered protein-protein interaction and post-translational modifications

  2. Results show that RNA-binding protein EWS (show EWSR1 Proteins) binds and regulates CCDC6 expression at RNA and protein levels.

  3. CCDC6 levels provide valuable insight for OS.

  4. the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.

  5. Expression of the CCDC6-RET fusion gene in LC-2/ad cells was demonstrated by the mRNA and protein levels, and the genomic break-point was confirmed by genomic DNA sequencing.

  6. CCDC6 is associated with cAMP signaling by fine regulating CREB1 (show CREB1 Proteins) transcriptional activity in normal and transformed thyroid cells.

  7. CCDC6-RET (show RET Proteins) fusion is associated with lung adenocarcinoma.

  8. It was shown that FBXW7 (show FBXW7 Proteins) interacts with and targets CCDC6 for ubiquitin-mediated proteasomal degradation. FBXW7 (show FBXW7 Proteins)-mediated CCDC6 degradation was impaired in response to DNA damage.

  9. Following genotoxic stress, loss or inactivation of CCDC6 in cancers that carry the CCDC6 fusion, accelerates the dephosphorylation of pH2AX S139, resulting in defective G2 arrest and premature mitotic entry.

  10. CCDC6 plays a key role in cell cycle control.

Mouse (Murine) Coiled-Coil Domain Containing 6 (CCDC6) interaction partners

  1. Ccdc6-ex2 knock-in mice developed thyroid hyperplasia associated with an enhanced CREB1 (show CREB1 Proteins) activity and an increased expression of the CREB-1 (show CREB1 Proteins) regulated genes.

  2. the loss of CCDC6 could aid the spermatogonial cells to be part of a pro-survival pathway that helps to evade the toxic effects of endogenous oxidants and contributes to testicular neoplastic growth.

CCDC6 Protein Profile

Protein Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.

Gene names and symbols associated with CCDC6

  • coiled-coil domain containing 6a (ccdc6a)
  • coiled-coil domain containing 6 (ccdc6)
  • coiled-coil domain containing 6 (LOC100224200)
  • coiled-coil domain containing 6 (CCDC6)
  • coiled-coil domain containing 6 (Ccdc6)
  • 2810012H18Rik protein
  • AA536681 protein
  • AA960498 protein
  • AW061011 protein
  • ccdc6 protein
  • D10S170 protein
  • fj36e04 protein
  • H4 protein
  • MGC53501 protein
  • PTC protein
  • TPC protein
  • TST1 protein
  • wu:fj36e04 protein
  • zgc:56563 protein
  • zgc:77435 protein

Protein level used designations for CCDC6

coiled-coil domain-containing protein 6 , coiled-coil domain containing 6 , papillary thyroid carcinoma-encoded protein

GENE ID SPECIES
335905 Danio rerio
379300 Xenopus laevis
100224200 Taeniopygia guttata
8030 Homo sapiens
423666 Gallus gallus
488993 Canis lupus familiaris
100155896 Sus scrofa
522998 Bos taurus
76551 Mus musculus
691155 Rattus norvegicus
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