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CCDC88C encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. Additionally we are shipping and many more products for this protein.
we demonstrated the relevance of Daple expression to gastric cancer progression.
Thus, Daple activates Galphai proteins and enhances non-canonical Wnt signaling by Frizzled receptors, and its dysregulation can impact both tumor initiation and progression to metastasis.
Spinocerebellar ataxia (show USP14 ELISA Kits) 40 (SCA40) displays typical cerebellar ataxia (show USP14 ELISA Kits) signs and pontocerebellar atrophy. Whole-exome sequencing led to the identification of a novel missense mutation in the gene CCDC88C in all SCA40-affected individuals. Cell-based assays showed that the SCA40 mutation causes an up-regulation of the JNK (show MAPK8 ELISA Kits) stress kinase signaling cascade that subsequently triggers programmed cell death.
LDI-PCR revealed a fusion between CCDC88C exon 25 and PDGFRB (show PDGFRB ELISA Kits) exon 11.
Our data validate CCDC88C as causing autosomal recessive, primary non-syndromic congenital hydrocephalus (show FOXC1 ELISA Kits), suggesting this gene may be an important cause of congenital hydrocephalus (show FOXC1 ELISA Kits).
Findings indicate that Daple interacts with Dishevelled (show DVL2 ELISA Kits) to direct the Dishevelled (show DVL2 ELISA Kits)/protein kinase (show CDK7 ELISA Kits) lambda protein complex to activate Rac (show AKT1 ELISA Kits), which in turn mediates the non-canonical Wnt (show WNT2 ELISA Kits) signalling pathway required for cell migration.
Identification of Daple, a Dvl-binding protein (show NKD1 ELISA Kits), that suppresses Wnt (show WNT2 ELISA Kits) signalling pathway.
This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus\; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain.
coiled-coil domain containing 88C
, DVL-binding protein DAPLE
, Dvl-associating protein with a high frequency of leucine residues
, hook-related protein 2
, protein Daple
, coiled-coil domain-containing protein 88C
, dvl-associating protein with a high frequency of leucine residues