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anti-Coiled-Coil Domain Containing 99 (CCDC99) Antibodies

Required for the localization of dynein and dynactin to the mitotic kintochore. Additionally we are shipping Coiled-Coil Domain Containing 99 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CCDC99 54908 Q96EA4
CCDC99 70385 Q923A2
CCDC99 303037 Q3KR99
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Top anti-Coiled-Coil Domain Containing 99 Antibodies at antibodies-online.com

Showing 10 out of 54 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB CCDC99 Antibody (C-term) (ABIN657427) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the CCDC99 antibody detected the CCDC99 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: CCDC99  Sample Tissue: Hela Whole cell lysates  Antibody Dilution: 1.0 µg/mL SPDL1 is supported by BioGPS gene expression data to be expressed in HeLa 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin-embedded human rectal carcinoma labeled with Anti-Spindly/CCDC99 Polyclonal Antibody, Unconjugatedused at 1:200 dilution for 40 minutes at 37°C. 100 μL Log in to see 14 to 21 Days
$269.50
Details
Human Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit PE IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
$201.19
Details
Human Rabbit Un-conjugated WB   200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Alexa Fluor 594 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

CCDC99 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Top referenced anti-Coiled-Coil Domain Containing 99 Antibodies

  1. Human Polyclonal CCDC99 Primary Antibody for IHC (p), WB - ABIN657427 : Barisic, Sohm, Mikolcevic, Wandke, Rauch, Ringer, Hess, Bonn, Geley: Spindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation. in Molecular biology of the cell 2010 (PubMed)
    Show all 2 references for ABIN657427

  2. Human Polyclonal CCDC99 Primary Antibody for ELISA, WB - ABIN1451181 : Schmutz, Martin, Terry, Couronne, Grimwood, Lowry, Gordon, Scott, Xie, Huang, Hellsten, Tran-Gyamfi, She, Prabhakar, Aerts, Altherr, Bajorek, Black, Branscomb, Caoile, Challacombe, Chan, Denys et al.: The DNA sequence and comparative analysis of human chromosome 5. ... in Nature 2004 (PubMed)

More Antibodies against Coiled-Coil Domain Containing 99 Interaction Partners

Fruit Fly (Drosophila melanogaster) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Spindly is a novel regulator of mitotic dynein, functioning specifically to target dynein to kinetochores.

Arabidopsis thaliana Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. SPINDLY regulates cortex proliferation by maintaining cellular redox homeostasis

  2. SPY plays a negative role in plant abiotic stress tolerance, probably by integrating environmental stress signals via gibberellic acid and Cytokinins cross talk.

  3. Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.

  4. spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants

  5. Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.

  6. SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.

Human Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin (show DCTN1 Antibodies), to prometaphase kinetochores. Both Spindly and CENP-E (show CENPE Antibodies) farnesylation are required for efficient chromosome congression

  2. hSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization.

  3. Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.

  4. dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing

  5. [hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10 (show ZW10 Antibodies)/Zwilch (show ZWILCH Antibodies) (RZZ) complex and Aurora B (show AURKB Antibodies).

Mouse (Murine) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Overexpression of mSpindly failed to enhance inactivation of SAC (show ADCY10 Antibodies) and acceleration of the meiotic process.

Coiled-Coil Domain Containing 99 (CCDC99) Antigen Profile

Protein Summary

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex (By similarity).

Gene names and symbols associated with CCDC99

  • CG15415 gene product from transcript CG15415-RB (Spindly) antibody
  • putative UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY (SPY) antibody
  • spindle apparatus coiled-coil protein 1 (spdl1) antibody
  • coiled-coil domain containing 99 (SPDL1) antibody
  • spindle apparatus coiled-coil protein 1 (SPDL1) antibody
  • spindle apparatus coiled-coil protein 1 (Spdl1) antibody
  • zgc:171223 (zgc:171223) antibody
  • 1700018I02Rik antibody
  • 2600001J17Rik antibody
  • 2810049B11Rik antibody
  • AA409762 antibody
  • Ccdc99 antibody
  • ccdc99-a antibody
  • ccdc99-b antibody
  • CG15415 antibody
  • Dmel\\CG15415 antibody
  • RGD1306908 antibody
  • spdl1 antibody
  • spdl1-a antibody
  • SPINDLY antibody

Protein level used designations for CCDC99

spindly , CG15415-PB , Spindly-PB , coiled-coil domain containing 99 , coiled-coil domain-containing protein 99 , protein Spindly , spindle apparatus coiled-coil domain-containing protein 1 , arsenite-related gene 1 protein , hSpindly , rhabdomyosarcoma antigen MU-RMS-40.4A , rrhabdomyosarcoma antigen protein MU-RMS-40.4A , spindly homolog , Coiled-coil domain-containing protein 99-A , protein Spindly-A , spindle apparatus coiled-coil domain-containing protein 1-A

GENE ID SPECIES
33578 Drosophila melanogaster
820327 Arabidopsis thaliana
100170491 Xenopus (Silurana) tropicalis
515158 Bos taurus
54908 Homo sapiens
70385 Mus musculus
303037 Rattus norvegicus
734358 Xenopus laevis
568360 Danio rerio
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