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Coiled-Coil and C2 Domain Containing 1A Proteins (CC2D1A)

CC2D1A encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. Additionally we are shipping Coiled-Coil and C2 Domain Containing 1A Antibodies (40) and Coiled-Coil and C2 Domain Containing 1A Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CC2D1A 54862 Q6P1N0
CC2D1A 212139 Q8K1A6
Rat CC2D1A CC2D1A 288908 Q66HA5
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Top Coiled-Coil and C2 Domain Containing 1A Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CC2D1A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Interaction Partners

Human Coiled-Coil and C2 Domain Containing 1A (CC2D1A) interaction partners

  1. Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1 (show CREB1 Proteins). Aki1 regulates CREB (show CREB1 Proteins) by modulating protein kinase A activity. The Aki1-CREB (show CREB1 Proteins) axis plays an important role in DMM (show COL2A1 Proteins) pathogenesis.

  2. Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD (show ARSD Proteins), and seizures. CC2D1A regulates NF-kappaB (show NFKB1 Proteins) signaling.

  3. All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt (show AKT1 Proteins) and increased the phosphorylation of cleaved PARP.

  4. Non-genomic downregulation of 5-HT1A receptor (show HTR1A Proteins) by 17betaestradiol does not involve NUDR (show DEAF1 Proteins) and Freud-1 proteins.

  5. TBK1 (show TBK1 Proteins)-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I (show DDX58 Proteins)-like receptors to antiviral immunity

  6. CHMP4B (show CHMP4A Proteins) interacts directly with CC2D1A and CC2D1B (show CC2D1B Proteins) with nanomolar affinity by forming a 1:1 complex.

  7. CC2D1A interaction with CHMP4B (show CHMP4A Proteins)/4A blocks HIV-1 budding.

  8. Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective.

  9. Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder.

  10. Data suggest that the anti-tumor activity of NF-kappaB (show NFKB1 Proteins) inhibitors is associated with p53 (show TP53 Proteins)-mediated activation of autophagy.

Mouse (Murine) Coiled-Coil and C2 Domain Containing 1A (CC2D1A) interaction partners

  1. CC2D1A and CC2D1B (show CC2D1B Proteins) role and function in the endocytic pathway and Notch (show NOTCH1 Proteins) signalling.

  2. TBK1 (show TBK1 Proteins)-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I (show DDX58 Proteins)-like receptors to antiviral immunity

  3. Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses.

  4. Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A (show HTR1A Proteins)) receptor transcriptional regulation.

  5. Freud-1 has a key role in regulating DRD2 (show DRD2 Proteins) expression

  6. Paper describes a function of Cc2d1a/Cc2d1b (show CC2D1B Proteins) and its Drosophila homologue l(2)gd in D.melanogaster in Notch (show NOTCH1 Proteins) trafficking.

  7. Novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression.

Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Protein Profile

Protein Summary

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.

Gene names and symbols associated with CC2D1A

  • coiled-coil and C2 domain containing 1A (CC2D1A)
  • coiled-coil and C2 domain containing 1A (cc2d1a)
  • coiled-coil and C2 domain containing 1A (Cc2d1a)
  • BC016188 protein
  • Freud-1 protein
  • Freud-1/Aki1 protein
  • MRT3 protein
  • RGD1306108 protein
  • Tape protein

Protein level used designations for CC2D1A

coiled-coil and C2 domain containing 1A , coiled-coil and C2 domain-containing protein 1A , coiled-coil and C2 domain-containing protein 1A-like , Akt kinase-interacting protein 1 , FRE under dual repression-binding protein 1 , five prime repressor element under dual repression-binding protein 1 , five repressor element under dual repression-binding protein 1 , mental retardation, nonsyndromic, autosomal recessive, 3 , putative NF-kappa-B-activating protein 023N , putative NFkB activating protein , 5-HT1A receptor , five' repressor element under dual repression binding protein 1 , freud-1

GENE ID SPECIES
468744 Pan troglodytes
484911 Canis lupus familiaris
513078 Bos taurus
718483 Macaca mulatta
100020918 Monodelphis domestica
100145460 Xenopus (Silurana) tropicalis
100482182 Ailuropoda melanoleuca
100603711 Nomascus leucogenys
54862 Homo sapiens
212139 Mus musculus
288908 Rattus norvegicus
100712639 Cavia porcellus
101119902 Ovis aries
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