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Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 Proteins (CHCHD4)

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008].. Additionally we are shipping CHCHD4 Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHCHD4 100361898 Q5BJN5
CHCHD4 131474 Q8N4Q1
CHCHD4 72170 Q8VEA4
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Top CHCHD4 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,289.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,297.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,297.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CHCHD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human , ,
, ,
Mouse (Murine)

More Proteins for Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) Interaction Partners

Human Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4) interaction partners

  1. Compared to wild type control littermates, mice with a knockout of CHCHD4 exhibit reduced weight gain when fed a high-fat diet.

  2. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17 (show COX17 Proteins)), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1 (show SOD1 Proteins)) in the cytoplasm were directly observed with in-cell NMR spectroscopy.

  3. our findings suggest that MIA40 reduction contributes to the effects of AIF (show AIFM1 Proteins) deficiency on OXPHOS, as it may impact on the correct assembly and maintenance of the respiratory subunits.

  4. Data indicate that poptosis-inducing factor (AIF (show AIFM1 Proteins)) controls the mitochondrial import of mitochondrial membrane transport protein CHCHD4.

  5. In aggregate these data suggest that the Mia40/lfALR system has a broad sequence specificity and that potential substrates may be protected from adventitious oxidation by kinetic sequestration within the mitochondrial IMS.

  6. Import and oxidative folding of proteins are kinetically and functionally coupled and depend on the expression of Mia40, ALR (show GFER Proteins), and the intracellular glutathione pool.

  7. Data indicate that decreased CHCHD4 expression prevents the mitochondrial translocation of p53 (show TP53 Proteins) while augmenting its nuclear localization and activity.

  8. illustrate a very atypical behaviour for the Mia40 precursor compared to other substrates of the MIA (show MIA Proteins) pathway. By contrast, interaction with Erv1 (show GFER Proteins) occurs after 5 min of import and relies on a more stringent specificity

  9. mitochondrial localization of MIA40 requires sulfhydryl oxidase ALR (show GFER Proteins) in heterologous expression yeast system.

  10. Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR (show GFER Proteins).

CHCHD4 Protein Profile

Protein Summary

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005

Gene names and symbols associated with CHCHD4

  • coiled-coil-helix-coiled-coil-helix domain containing 4 (chchd4-a)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (CHCHD4)
  • LY6/PLAUR domain containing 6B (lypd6b)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (chchd4)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (chchd4-b)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (LOC100224104)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (LOC100361898)
  • coiled-coil-helix-coiled-coil-helix domain containing 4 (Chchd4)
  • similar to internal region of S. cerevisiae essential mitochondrial protein FMP15 (YKL195W); same as cosmid orf Ca49C10.16 (CaO19.10494)
  • 2410012P20Rik protein
  • 2810014D17Rik protein
  • AI838740 protein
  • chchd4 protein
  • chchd4a protein
  • chchd4b protein
  • fc10g04 protein
  • MIA40 protein
  • si:dkey-202e22.1 protein
  • TIMM40 protein
  • wu:fc10g04 protein
  • zgc:100849 protein
  • zgc:113301 protein

Protein level used designations for CHCHD4

mitochondrial intermembrane space import and assembly protein 40-A , mitochondrial intermembrane space import and assembly protein 40 , coiled-coil-helix-coiled-coil-helix domain-containing protein 4-A , CHCHD4 , coiled-coil-helix-coiled-coil-helix domain-containing protein 4 , coiled-coil-helix-coiled-coil-helix domain containing 4 , mitochondrial intermembrane space import and assembly protein 40-B , coiled-coil-helix-coiled-coil-helix domain-containing protein 4-B , mitochondrial intermembrane space import and assembly 40 homolog , translocase of inner mitochondrial membrane 40 homolog , potential mitochondrial protein

GENE ID SPECIES
414630 Xenopus laevis
416037 Gallus gallus
553752 Danio rerio
476520 Canis lupus familiaris
394473 Xenopus (Silurana) tropicalis
445144 Danio rerio
470755 Pan troglodytes
494790 Xenopus laevis
700814 Macaca mulatta
100224104 Taeniopygia guttata
100361898 Rattus norvegicus
131474 Homo sapiens
72170 Mus musculus
312559 Rattus norvegicus
513889 Bos taurus
3637171 Candida albicans SC5314
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