Coiled-Coil Domain Containing 99 (CCDC99) ELISA Kits

Required for the localization of dynein and dynactin to the mitotic kintochore. Additionally we are shipping Coiled-Coil Domain Containing 99 Antibodies (44) and Coiled-Coil Domain Containing 99 Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human CCDC99 CCDC99 54908 Q96EA4
Anti-Mouse CCDC99 CCDC99 70385 Q923A2
Anti-Rat CCDC99 CCDC99 303037 Q3KR99
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More ELISA Kits for Coiled-Coil Domain Containing 99 Interaction Partners

Fruit Fly (Drosophila melanogaster) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Spindly is a novel regulator of mitotic dynein, functioning specifically to target dynein to kinetochores.

Arabidopsis thaliana Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. posttranslational modification of TCP14/15 by SPY inhibits their proteolysis.

  2. The study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development.

  3. SPINDLY regulates cortex proliferation by maintaining cellular redox homeostasis

  4. SPY plays a negative role in plant abiotic stress tolerance, probably by integrating environmental stress signals via gibberellic acid and Cytokinins cross talk.

  5. Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.

  6. spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants

  7. Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.

  8. SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.

Human Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin (show DCTN1 ELISA Kits), to prometaphase kinetochores. Both Spindly and CENP-E (show CENPE ELISA Kits) farnesylation are required for efficient chromosome congression

  2. hSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization.

  3. Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.

  4. dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing

  5. [hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10 (show ZW10 ELISA Kits)/Zwilch (show ZWILCH ELISA Kits) (RZZ) complex and Aurora B (show AURKB ELISA Kits).

Mouse (Murine) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Overexpression of mSpindly failed to enhance inactivation of SAC (show ADCY10 ELISA Kits) and acceleration of the meiotic process.

Coiled-Coil Domain Containing 99 (CCDC99) Antigen Profile

Antigen Summary

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex (By similarity).

Gene names and symbols associated with CCDC99

  • CG15415 gene product from transcript CG15415-RB (Spindly) antibody
  • putative UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY (SPY) antibody
  • spindle apparatus coiled-coil protein 1 (spdl1) antibody
  • coiled-coil domain containing 99 (SPDL1) antibody
  • spindle apparatus coiled-coil protein 1 (SPDL1) antibody
  • spindle apparatus coiled-coil protein 1 (Spdl1) antibody
  • zgc:171223 (zgc:171223) antibody
  • 1700018I02Rik antibody
  • 2600001J17Rik antibody
  • 2810049B11Rik antibody
  • AA409762 antibody
  • Ccdc99 antibody
  • ccdc99-a antibody
  • ccdc99-b antibody
  • CG15415 antibody
  • Dmel\\CG15415 antibody
  • RGD1306908 antibody
  • spdl1 antibody
  • spdl1-a antibody
  • SPINDLY antibody

Protein level used designations for CCDC99

spindly , CG15415-PB , Spindly-PB , coiled-coil domain containing 99 , coiled-coil domain-containing protein 99 , protein Spindly , spindle apparatus coiled-coil domain-containing protein 1 , arsenite-related gene 1 protein , hSpindly , rhabdomyosarcoma antigen MU-RMS-40.4A , rrhabdomyosarcoma antigen protein MU-RMS-40.4A , spindly homolog , Coiled-coil domain-containing protein 99-A , protein Spindly-A , spindle apparatus coiled-coil domain-containing protein 1-A

33578 Drosophila melanogaster
820327 Arabidopsis thaliana
100170491 Xenopus (Silurana) tropicalis
515158 Bos taurus
54908 Homo sapiens
70385 Mus musculus
303037 Rattus norvegicus
734358 Xenopus laevis
568360 Danio rerio
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