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Coilin Proteins (COIL)

The protein encoded by COIL is an integral component of Cajal bodies (also called coiled bodies). Additionally we are shipping Coilin Antibodies (68) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COIL 8161 P38432
COIL 12812  
Rat COIL COIL 50998  
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Top Coilin Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

COIL Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for Coilin (COIL) Interaction Partners

Fruit Fly (Drosophila melanogaster) Coilin (COIL) interaction partners

  1. Coiled, a member of the leukocyte antigen 6 (Ly6) family, is crucial for septate junction formation and blood-brain barrier integrity.

  2. coilin is required for normal Cajal body organization in Drosophila but is not essential for viability or production of functional gametes

Arabidopsis thaliana Coilin (COIL) interaction partners

  1. Physical properties of deletion mutants indicate that coilin might consist of an N-terminal globular domain, a central highly disordered domain and a C-terminal domain containing a Tudor-like structure adjacent to a disordered C terminus. [coilin]

  2. interaction between viral protein and coilin

Human Coilin (COIL) interaction partners

  1. The existence of chromatolysis and eccentric nuclei in SMA (show SMN1 Proteins) motor neurons correlates with Cajal body disruption and nucleolar relocalization of coil in, a Cajal body marker.

  2. VRK1 (show VRK1 Proteins) is a novel regulator of CBs (show CBS Proteins) dynamics and stability in cell cycle by protecting coilin from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  3. Data indicate that annexin A2 (show ANXA2 Proteins) overexpression in microsatellite instability (MIN) cells induces disassembly and colocalization of coilin with centromeres.

  4. The study shows that coilin-KO human cells that lack Cajal bodies are phenotypically normal with respect to telomere homeostasis.

  5. Coilin couples snRNA and snoRNA biogenesis, making cajal bodies the cellular hub of small ncRNA metabolism.

  6. The interaction of SMN (show STMN1 Proteins) with the spliceosomal SmD1 (show SNRPD1 Proteins) (also known as SNRPD1 (show SNRPD1 Proteins)), severely decreases SMN (show STMN1 Proteins)-coilin interaction and prevents Cajal body assembly.

  7. Results suggest that UBL5 (show PIN1 Proteins) could be targeted to Cajal bodies (CBs (show CBS Proteins)) via its interaction with coilin.

  8. coilin is subjected to regulated specific proteolysis by calpain, and this processing may play a role in the regulation of coilin activity and Cajal body formation

  9. Data indicate coilin involvement in the processing of telomerase RNA both in vitro and in vivo.

  10. investigated the role of coilin in the DNA damage response and found that coilin reduction correlated with significantly increased levels of soluble gammaH2AX (show H2AFX Proteins) in etoposide treated U2OS cells

Mouse (Murine) Coilin (COIL) interaction partners

  1. These findings demonstrate that coilin modifications or levels impact artificial reporter splicing, possibly by influencing small nuclear ribonucleoprotein biogenesis.

  2. Putative role of coilin in formation of complexes with ribosomal RNA synthesis/processing components is discussed.

  3. evolutionary conservation of coilin from plants to animals suggests that the protein plays an important role, perhaps coordinating the activities of various RNA-processing machineries

Coilin (COIL) Protein Profile

Protein Summary

The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.

Gene names and symbols associated with Coilin Proteins (COIL)

  • Coilin (p80c)
  • coilin (COIL)
  • coilin (coil)
  • coilin (LOC100218802)
  • sphere organelles protein-related protein (AT1G13030)
  • coilin (Coil)
  • coilin p80 (coil)
  • sphere organelle protein sph-1 (coil)
  • C79982 protein
  • CG8710 protein
  • Cln80 protein
  • coil protein
  • Coilin protein
  • Dmel\\CG8710 protein
  • F3F19.5 protein
  • F3F19_5 protein
  • LOC100218802 protein
  • p80 protein
  • p80-coilin protein
  • p80c protein
  • sph1 protein
  • wu:fb08h11 protein

Protein level used designations for Coilin Proteins (COIL)

Coilin , coilin , CG8710-PC , CG8710-PD , coil-PC , coil-PD , dcoilin , coilin p80 , p80 , nuclear phosphoprotein of Cajal body , sphere organelles protein SPH-1 , sphere protein 1

100301694 Oncorhynchus mykiss
417402 Gallus gallus
496934 Xenopus (Silurana) tropicalis
35785 Drosophila melanogaster
100218802 Taeniopygia guttata
837860 Arabidopsis thaliana
100600301 Nomascus leucogenys
8161 Homo sapiens
480564 Canis lupus familiaris
507580 Bos taurus
12812 Mus musculus
50998 Rattus norvegicus
455147 Pan troglodytes
100070720 Equus caballus
100343244 Oryctolagus cuniculus
100727482 Cavia porcellus
58024 Danio rerio
397940 Xenopus laevis
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