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Collagen, Type I, alpha 1 Proteins (COL1A1)

COL1A1 encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Additionally we are shipping COL1A1 Antibodies (60) and COL1A1 Kits (34) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL1A1 1277 P02452
COL1A1 12842 P11087
COL1A1 29393 P02454
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Top COL1A1 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$686.40
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,029.50
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated 100 μg Log in to see 11 to 13 Days
$686.40
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$857.60
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   50 μg Log in to see 16 to 21 Days
$314.29
Details

COL1A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Collagen, Type I, alpha 1 (COL1A1) Interaction Partners

Human Collagen, Type I, alpha 1 (COL1A1) interaction partners

  1. Results showed that the presence of the 's' allele of the COL1A1 Sp1 (show PSG1 Proteins) polymorphism in individuals with epilepsy was related to lower bone mineral density in the lumbar and femur and thus an increased risk of osteoporosis.

  2. Deletions encompassing not only COL1A1 but also neighboring genes can lead to contiguous gene syndromes that may include dental involvement and learning disability with Osteogenesis Imperfecta (show COL1A2 Proteins).

  3. Case Report: congenital atrophic dermatofibrosarcoma protuberans with COL1A1-PDGFB rearrangement.

  4. Two gross deletions have been found in the genes coding for collagen type I in the Chinese osteogenesis imperfecta (show COL1A2 Proteins) population, and the deletion of exons 17 to 23 in the COL1A2 (show COL1A2 Proteins) gene is a novel mutation.

  5. HRG (show NRG1 Proteins) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  6. The properties of VEGFR2 (show KDR Proteins) and c-telopeptide collagen observed in this study inform the design of future combination antiangiogenic therapy trials.

  7. Productive complex between MMP-12 (show MMP12 Proteins) and synthetic triple-helical collagen V, are revealed through paramagnetic NMR.

  8. Studies investigating the association between the COL1A1 gene -1997G/T polymorphism and the risk of osteoporosis in postmenopausal women have reported conflicting results. We performed a meta-analysis to make a more precise estimation of this relationship

  9. Mast cell density and expression of MMP-9 (show MMP9 Proteins), RANKL (show TNFSF11 Proteins) and Ntx correlated positively with of bone disease severity in multiple myeloma patients.

  10. 3235G>A and 3247G>A mutations in exon 45 of the COL1A1 gene cause osteogenesis imperfect.

Mouse (Murine) Collagen, Type I, alpha 1 (COL1A1) interaction partners

  1. Col1 expression was seen in the cartilage zone of the mandibular condyle cartilage.

  2. HRG (show HRG Proteins) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  3. Calreticulin (show CALR Proteins) in mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation.

  4. Homocysteine Induces Collagen I Expression by Downregulating Histone Methyltransferase G9a (show EHMT2 Proteins)

  5. These data suggested that intestinal epithelial cells were injured after IM treatment through the pVHL (show VHL Proteins) overexpression-induced degradation of collagen I or HIF-1alpha (show HIF1A Proteins).

  6. lipid nanoparticles loaded with small interfering RNA to the procollagen alpha1(I) gene specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases

  7. low-level laser therapy influences the expression of col1a1 and vegf in a mouse fibroblast cell line.

  8. Hgh fat diet increased TGFbeta1 (show TGFB1 Proteins) protein expression, Smad3 (show SMAD3 Proteins) activation, and collagen deposition in skeletal muscle, and exercise attenuated TGFbeta1 (show TGFB1 Proteins) protein expression and collagen deposition in skeletal muscle.

  9. Data show that caveolin-1 (Cav-1 (show CAV1 Proteins)) is up-regulated, but collagen I (COL (show HDAC1 Proteins) I) is down-regulated, in chronologically-aged skin of human and mouse.

  10. During heart valve development, Krox20 (show EGR2 Proteins)-mediated activation of fibrillar Col1a1 and Col3a1 (show COL3A1 Proteins) genes is crucial to avoid postnatal degeneration of the aortic valve leaflets.

Cow (Bovine) Collagen, Type I, alpha 1 (COL1A1) interaction partners

  1. These observations support a signaling network among JNKs, Smads, Snail1 (show SNAI1 Proteins), and cortactin (show CTTN Proteins) to regulate the invasion of MDA-MB-231 cells embedded in 3D collagen I, which may be targeted during screening of anti-invasion reagents.

  2. Data show that biglycan (show BGN Proteins), collagen type I, collagen type II, decorin (show DCN Proteins), and versican (show Vcan Proteins) were significantly affected by vibration duration, frequency, and amplitude.

  3. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V

  4. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen (show COL1A2 Proteins)

  5. These results demonstrate a novel and important functional role of the DDR2 (show DDR2 Proteins) extracellular domain that may contribute to collagen regulation via modulation of fibrillogenesis.

  6. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

  7. A molecular model of collagen hydration is used to validate centrifugal dehydration force (CDF (show CTNNA2 Proteins)) and re-hydration isotherm (RHI) methods to measure and characterize hydration compartments on bovine tendon.

Rabbit Collagen, Type I, alpha 1 (COL1A1) interaction partners

  1. Ammonium perchlorate can increase gene expressions of types I, III collagens, TGF-beta(1 (show TGFB1 Proteins)) and TNF-alpha (show TNF Proteins) in lung of rabbits.

Pig (Porcine) Collagen, Type I, alpha 1 (COL1A1) interaction partners

COL1A1 Protein Profile

Protein Summary

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Gene names and symbols associated with COL1A1

  • collagen, type I, alpha 1 (col1a1)
  • collagen, type I, alpha 1 (COL1A1)
  • collagen 1a1 (col1a1)
  • collagen, type I, alpha 1 (Col1a1)
  • Col1a-1 protein
  • COL1A1 protein
  • COL1A2 protein
  • Cola-1 protein
  • Cola1 protein
  • COLIA1 protein
  • MGC52532 protein
  • Mov-13 protein
  • Mov13 protein
  • OI4 protein

Protein level used designations for COL1A1

collagen, type I, alpha 1 , alpha 1 type I collagen , collagen, type I, alpha 2 , collagen type I alpha 1 , procollagen alpha 1 (I) , collagen 1a1 , alpha-1 type I collagen , collagen alpha 1 chain type I , collagen alpha-1(I) chain , collagen alpha-1(I) chain preproprotein , collagen of skin, tendon and bone, alpha-1 chain , pro-alpha-1 collagen type 1 , alpha-1 type 1 collagen , procollagen, type I, alpha 1 , alpha-1 collagen (I) , collagen alpha-1 chain , type I collagen pre-pro-alpha1(I) chain , prepro-alpha-1 collagen type I , type I collagen alpha 1 chain , type I collagen alpha1 , pro-alpha-1 type 1 collagen , collagen, type 1, alpha 1 , procollagen type I, alpha 1 , procollagen, type 1, alpha 1

GENE ID SPECIES
380515 Xenopus laevis
443483 Ovis aries
455117 Pan troglodytes
574201 Macaca mulatta
100033877 Equus caballus
100135778 Oncorhynchus mykiss
1277 Homo sapiens
12842 Mus musculus
282187 Bos taurus
395532 Gallus gallus
403651 Canis lupus familiaris
100008952 Oryctolagus cuniculus
397571 Sus scrofa
100733209 Cavia porcellus
29393 Rattus norvegicus
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