anti-Collagen, Type I, alpha 2 (COL1A2) Antibodies

COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Additionally we are shipping Collagen, Type I, alpha 2 Kits (63) and Collagen, Type I, alpha 2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COL1A2 1278 P08123
COL1A2 12843 Q01149
COL1A2 84352 P02466
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Top anti-Collagen, Type I, alpha 2 Antibodies at antibodies-online.com

Showing 10 out of 100 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-COL1A2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Human Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB <span>COL1A2 Antibody (N-term) western blot analysis in T47D cell line lysates (35µg/lane).This demonstrates the COL1A2 antibody detected the COL1A2 protein (arrow).</span> 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Collagen 1 alpha 2 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Collagen 1 alpha 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of Collagen 1 alpha 2 expression in Jurkat (A) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Dog Rabbit Un-conjugated IC, IF, IP, IHC, WB Immunofluorescent analysis of Collagen 1 alpha 2 staining in A431 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Collagen 1 alpha 2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB <b>Immunohistochemistry</b> (IHC) analyzes of COL1A2 antibody in paraffin-embedded human colon carcinoma tissue. <b>Western blot</b> (WB) analysis of COL1A2 antibody in extracts from 293 cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from Jurkat cells, treated with etoposide 25uM 24h, using Collagen I alpha2 (Cleaved-Gly1102) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from 293/HeLa cells, using Collagen I alpha2 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Collagen I alpha2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), IHC, WB Immunohistochemistry-Paraffin: COL1A2 Antibody [NBP1-19699] - Paraffin-embedded human breast carcinoma tissue at 1:50. 0.1 mL Log in to see 7 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB 50 μL Log in to see 7 to 9 Days
$451.00
Details

COL1A2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Collagen, Type I, alpha 2 Antibodies

  1. Human Polyclonal COL1A2 Primary Antibody for ICC, IF - ABIN439152 : Veronesi, Murgia, Caselli, Grisendi, Piccinno, Rasini, Giordano, Montemurro, Bourin, Sensebé, Rojewski, Schrezenmeier, Layrolle, Ginebra, Panaitescu, Gómez-Barrena, Catani, Paolucci, Burns, Dominici: Transportation conditions for prompt use of ex vivo expanded and freshly harvested clinical-grade bone marrow mesenchymal stromal/stem cells for bone regeneration. in Tissue engineering. Part C, Methods 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal COL1A2 Primary Antibody for IF, IHC (p) - ABIN498442 : Grohmann, Taetzner, Theuss, Kuehnel, Buchwald, Einspanier: The conclusiveness of less-invasive imaging techniques (computer tomography, X-ray) with regard to their identification of bone diseases in a primate model (Callithrix jacchus). in Journal of medical primatology 2012 (PubMed)

More Antibodies against Collagen, Type I, alpha 2 Interaction Partners

Human Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. We suggest that the mutation p.G337C in the COL1A2 gene is pathogenic for osteogenesis imperfecta by affecting the protein structure and the function of collagen.

  2. Identify PDGFRbeta as a driver in activating Akt (show AKT1 Antibodies)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.

  3. Flightless-I (Drosophila) homolog (FLII (show FLII Antibodies)) activates TGFbeta1 (show TGFB1 Antibodies)-mediated expression of COL1A2 gene.

  4. In the individuals with a COL1A2 mutation, 80% (8/10) of those with a glycine substitution located C terminal of p.Gly211 exhibited DGI (show DSG1 Antibodies) in both dentitions while no individual (0/5) with a mutation N-terminal of this point (p = 0.007) exhibited DGI (show DSG1 Antibodies) in either dentition.

  5. COL1A2 expression was positively related to tumor size, depth of invasion, and to lower overall survival of gastric cancer patients.

  6. the present study demonstrated that the INS (show INS Antibodies)/DEL polymorphism in the 3'UTR (show UTS2R Antibodies) of COL1A2 is able to interfere with the interaction between miRNA and mRNA. In addition, it is the first study, to the best of our knowledge, to indicate that the minor allele (Del) is associated with a reduced risk of developing osteoporosis.

  7. These findings may improve understanding of the pathogenic gene mutation spectrum and the clinical manifestations of mutations of COL1A1 (show COL1A1 Antibodies) and COL1A2 genes in Chinese patients with OI.

  8. THBS2 (show THBS2 Antibodies), but not COL1A2 and SPP1 (show SPP1 Antibodies), may serve as an indicator of gastric cancer prognosis.

  9. spine radiographs and charts of 437 patients (227 female) with osteogenesis imperfecta caused by mutations in COL1A1 (show COL1A1 Antibodies) or COL1A2 were evaluated and compared the relationship between scoliosis, genotype and bisphosphonate treatment history.

  10. The overexpression of let7b was observed to upregulate the protein expression levels of COL1A1 (show COL1A1 Antibodies) and COL1A2, while knockdown of let7b reduced the levels of COL1A1 (show COL1A1 Antibodies) and COL1A2 in skin fibroblasts

Cow (Bovine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen

  2. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

Mouse (Murine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. Identify PDGFRbeta as a driver in activating Akt (show AKT1 Antibodies)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.

  2. Insulin receptor substrate-1 (show IRS1 Antibodies) time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (show MLXIP Antibodies)-342

  3. Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin (show CDH2 Antibodies) pathway.

  4. evidence that FOXL2 (show FOXL2 Antibodies) modulates Col1a2 transcription through interaction with a response element 65 Kb upstream of the transcription start site

  5. Data indicate that insulin-like growth factor 1 (IGF1 (show IGF1 Antibodies)) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6 (show LARP6 Antibodies)) expression via a posttranscriptional mechanism.

  6. The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis (show SCX Antibodies) to modulate the expression of its target genes while also attenuating TGFbeta (show TGFB1 Antibodies)-induced expression of type I collagen and myofibroblast phenotype conversion marker genes

  7. Decreased expression of Krox20 (show EGR2 Antibodies) in mice causes down-regulation of Col1A2 expression, degeneration of the aortic leaflets and disorganization of the extracellular matrix, causing valvular dysfunction.

  8. Resveratrol effectively inhibits collagen I synthesis in IGF-1 (show IGF1 Antibodies)-stimulated colonic fibroblasts, partly by inhibiting IGF-1R (show IGF1R Antibodies) activation, and SIRT1 (show SIRT1 Antibodies) is also responsible for the process.

  9. Sp7/Osterix (show SP7 Antibodies) induces the mouse Col1a2 expression via the proximal promoter in osteoblastic cells in association with osteoblast differentiation.

  10. Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 (show LIN28A Antibodies) upregulates collagen expression in glomerular mesangial cells from diabetic mice.

Pig (Porcine) Collagen, Type I, alpha 2 (COL1A2) interaction partners

Zebrafish Collagen, Type I, alpha 2 (COL1A2) interaction partners

  1. ven though in adult bone, skin and scales equal amounts of a1(col1a1a) a2(col1a2) and a3(col1a2)chains are present, the presented data suggest a tissue-specific stoichiometry and/or post-translational modification status for collagen type I

Collagen, Type I, alpha 2 (COL1A2) Antigen Profile

Protein Summary

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Gene names and symbols associated with COL1A2

  • collagen type I alpha 2 (LOC100860940) antibody
  • collagen, type 1, alpha 2 (col1a2) antibody
  • collagen, type I, alpha 2 (COL1A2) antibody
  • collagen, type I, alpha 2 (Col1a2) antibody
  • collagen, type I, alpha 2 (col1a2) antibody
  • AA960264 antibody
  • AI325291 antibody
  • alpha2(I) antibody
  • Col1a-2 antibody
  • Cola-2 antibody
  • Cola2 antibody
  • hm:zehn2357 antibody
  • OI4 antibody
  • oim antibody
  • wu:fa98d05 antibody
  • wu:fa99g10 antibody
  • wu:fb04c08 antibody
  • wu:fb11d06 antibody
  • zehn2357 antibody

Protein level used designations for COL1A2

procollagen, type I, alpha 2 , alpha 2(I) collagen , alpha-2 type I collagen , alpha-2(1) collagen , collagen alpha 2(I) chain , collagen alpha-2(I) chain , alpha 2(I)-collagen , collagen I, alpha-2 polypeptide , collagen of skin, tendon and bone, alpha-2 chain , type I procollagen , COL1A2 gene exons 8 through 12 , type I procollagen pro-alpha 2 chain , alpha 2(I) procollagen , collagen I alpha-2 polypeptide , collagen COL1A2 , osteogenesis imperfecta , alpha 2 type I collagen , collagen a2(I)

GENE ID SPECIES
100860940 Capra hircus
380419 Xenopus laevis
396243 Gallus gallus
1278 Homo sapiens
403824 Canis lupus familiaris
282188 Bos taurus
100008997 Oryctolagus cuniculus
12843 Mus musculus
84352 Rattus norvegicus
100719158 Cavia porcellus
100626716 Sus scrofa
336471 Danio rerio
100135811 Oncorhynchus mykiss
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