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anti-Collagen, Type II, alpha 1 (COL2A1) Antibodies

COL2A1 encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Additionally we are shipping COL2A1 Kits (41) and COL2A1 Proteins (13) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
COL2A1 12824 P28481
COL2A1 1280 P02458
COL2A1 25412 P05539
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Top anti-COL2A1 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with COL2A1 antibody (N-term) (ABIN388526), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-COL2A1 Antibody (C-term) (ABIN388180) in 293 cell line lysates (35 µg/lane). COL2A1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated IHC (fro), WB Anti-Collagen II antibody,  Western blotting Lane 1: Rat Heart Tissue Lysate Lane 1: Rat Brain Tissue Lysate Anti- COL2A1 antibody, Western blotting All lanes: Anti COL2A1  at 0.5ug/ml Lane 1: COLO320 Whole Cell Lysate at 40ug Lane 2: HELA Whole Cell Lysate at 40ug Lane 3: MCF-7Whole Cell Lysate at 40ug Lane 4: A549 Whole Cell Lysate at 40ug Lane 5: JURKAT Whole Cell Lysate at 40ug Predicted bind size: 134 KD Observed bind size: 170KD 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (55.22 KDa) . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$369.79
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$385.00
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$396.00
Details
Mouse Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$396.00
Details
Rat Rabbit Un-conjugated ICC, IHC (fro), IHC (p), ELISA, WB 100 μg Log in to see 9 to 11 Days
$418.00
Details

COL2A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-COL2A1 Antibodies

  1. Human Monoclonal COL2A1 Primary Antibody for ELISA, WB - ABIN560425 : Jin, Moreira Teixeira, Krouwels, Dijkstra, van Blitterswijk, Karperien, Feijen: Synthesis and characterization of hyaluronic acid-poly(ethylene glycol) hydrogels via Michael addition: An injectable biomaterial for cartilage repair. in Acta biomaterialia 2010 (PubMed)
    Show all 5 references for ABIN560425

  2. Human Polyclonal COL2A1 Primary Antibody for WB - ABIN388180 : Olavarrieta, Morales-Angulo, del Castillo, Moreno, Moreno-Pelayo: Stickler and branchio-oto-renal syndromes in a patient with mutations in EYA1 and COL2A1 genes. in Clinical genetics 2008 (PubMed)

More Antibodies against COL2A1 Interaction Partners

Horse (Equine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. In contrast to previous studies using C2C the present study demonstrated that synovial levels of Coll2 (show SEMA3D Antibodies)-1 were significantly elevated in tarsocrural joints affected with osteochondrosis

  2. These results suggested that serum and synovial fluid (SF) collagen type II (CTX (show VSIG1 Antibodies)-II) concentrations and SF:serum CTX (show VSIG1 Antibodies)-II ratio may be used to detect cartilage degradation in horses with joint injury.

Rabbit Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. The expression of II type collagen and MMP-7 (show MMP7 Antibodies) is correlated to a retrogression of acetabular cartilage and increases obviously in early developmental dysplasia. [MMP7 (show MMP7 Antibodies)]

Mouse (Murine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Col2 expression was seen in the prehypertrophic zone of the mandibular condyle cartilage.

  2. Rspo2 (show RSPO2 Antibodies) activates Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling to reduce Col2a1 and Sox9 (show SOX9 Antibodies) and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage

  3. The MC13 mutation in Col2a1 causes an incompletely penetrant splicing defect.

  4. The mutant G1170S Col2a1 gene in mice clearly alters the transgenic murine phenotype and cartilage matrix homeostasis.

  5. Data indicate that tamoxifen decreased collage type II COL2A1 by activating matrix metallopeptidases MMP-2 (show MMP2 Antibodies)/13 expression.

  6. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA (show SMN1 Antibodies) during scleral chondrogenesis accompany myopia development.

  7. Results indicate the ability of type II collagen (CII) to generate CII-specific anterior chamber-associated immune deviation (ACAID)-mediated immune tolerance in vivo and in vitro in both DBA/1 (show RPS19 Antibodies) mice and C57BL/6 mice.

  8. expression of the Col2a1 IIC splice form may have a regulatory function in controlling alternative splicing of exon 2 to generate defined proportions of IIA, IID and IIB procollagen isoforms during cartilage development

  9. regulates Mac-1 (show ITGAM Antibodies)-mediated complement-dependent phagocytosis

  10. characterization of the Col2a1(+ex2) mice has surprisingly shown that disruption of alternative splicing does not affect overt cartilage formation

Human Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Dysspondyloenchondromatosis is associated with COL2A1 mutation.

  2. Constitutive mutation in COL2A1 gene is associated with Kniest dysplasia and chondrosarcoma.

  3. Serum CTX (show CYP27A1 Antibodies)-II levels in human brucellosis were higher than those of healthy controls but serum CTX (show CYP27A1 Antibodies)-II levels in male patients were significantly higher than those of female patients indicating biological changes in cartilage and bone in human brucellosis.

  4. Results identified a novel COL2A1 variant (c.619G>A, p.Gly207Arg) causing a distinct type II collagenopathy with features of progressive pseudorheumatoid dysplasia and spondyloepiphyseal dysplasia, Stanescu type.

  5. estimated median of 95 months as compared to an estimated median of 16 months for subjects expressing other levels of COL2A1 and SLC6A10P

  6. a novel mutation, c.620G>A (p.Gly207Glu), in the collagen type II alpha-1 gene; genotype-phenotype relationship between mutations and clinical findings of Spondyloepiphyseal dysplasia congenita

  7. Identified is a novel Col2a1 mutant mouse possessing a p.Tyr1391Ser missense mutation. Endoplasmic reticulum stress-mediated apoptosis contributes to a skeletal dysplasia resembling platyspondylic lethal skeletal dysplasia, Torrance type, in this line.

  8. A unique case of spondyloepiphyseal dysplasia congenita with mild coxa vara caused by double de novo COL2A1 mutations (p.G504S, p.G612A) located on the same allele.

  9. This study demonstrated that Genes overexpressed in Pilomyxoid Astrocytoma vs. Pilocytic Astrocytoma, ranked according to fold-change, included developmental genes H19 (show NCKAP1 Antibodies), DACT2 (show DACT2 Antibodies),COL2A1; COL1A1 (show COL1A1 Antibodies) and IMP3 (show IGF2BP3 Antibodies).

  10. c.2224G>A (p.Gly687Ser) is a novel mutation of COL2A1 associated with spondyloepiphyseal dysplasia congenital.

Pig (Porcine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells.

Cow (Bovine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Denaturation of the chimeric collagen increased its affinity for fibronectin (show FN1 Antibodies), as seen for mammalian collagens.

  2. Data show that expression of mRNAs for aggrecan (show ACAN Antibodies), collagen type II, and versican (show Vcan Antibodies) were significantly effected by the intervention.

  3. Data show that biglycan (show BGN Antibodies), collagen type I, collagen type II, decorin (show DCN Antibodies), and versican (show Vcan Antibodies) were significantly affected by vibration duration, frequency, and amplitude.

  4. specific ADAMTS-2 (show Adamts2 Antibodies) domains cleave the aminopropeptide of fibrillar procollagens types I-III and V

  5. Changes in aggrecan (show ACAN Antibodies) and type II collagen promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.

  6. SMase down-regulates type II collagen in articular chondrocytes via activation of the ERK signaling cascade, redistribution of SOX9, and recruitment of c-Fos

  7. Response of the chondrocyte to a cryptic sequence of denaturated type II collagen may play a role in naturally occurring hypertrophy in endochondral ossification and in the development of cartilage pathology in osteoarthritis.

  8. IGF-I (show IGF1 Antibodies) dose-dependently maintained cartilage formation

COL2A1 Antigen Profile

Protein Summary

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Gene names and symbols associated with COL2A1

  • collagen, type II, alpha 1 (col2a1) antibody
  • collagen, type II, alpha 1 (col2a1b) antibody
  • collagen, type II, alpha 1 (COL2A1) antibody
  • collagen, type II, alpha 1 (Col2a1) antibody
  • type II Collagen (LOC100009005) antibody
  • ANFH antibody
  • AOM antibody
  • CB11 antibody
  • CG2A1A antibody
  • Col2 antibody
  • Col2a antibody
  • Col2a-1 antibody
  • COL2A1 antibody
  • col2a1a antibody
  • COL11A3 antibody
  • COLLII antibody
  • Del1 antibody
  • Dmm antibody
  • Lpk antibody
  • M100856 antibody
  • Rgsc856 antibody
  • SEDC antibody

Protein level used designations for COL2A1

alpha-1 type II collagen , collagen alpha-1(II) chain , alpha-1 type II' collagen , collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) , collagen, type II, alpha 1 , collagen alpha-1(II) chain-like , type II collagen , collagen type IIA , chondrocalcin , disproportionate micromelia , procollagen, type II, alpha 1 , cartilage collagen , collagen II, alpha-1 polypeptide , alpha 1 type II procollagen , alpha 1 type IIA collagen , procollagen alpha 1(II) , Procollagen II alpha 1 , collagen type II (Col2A1) gene, enhancer region , pro alpha1 type II collagen , collagen type II , type II collagen alpha1 , cyanogen bromide , pro-alpha 1(II)

GENE ID SPECIES
394828 Xenopus (Silurana) tropicalis
397739 Xenopus laevis
451860 Pan troglodytes
100433193 Pongo abelii
100474711 Ailuropoda melanoleuca
791241 Equus caballus
100008672 Oryctolagus cuniculus
100588525 Nomascus leucogenys
12824 Mus musculus
1280 Homo sapiens
395069 Gallus gallus
25412 Rattus norvegicus
100009005 Oryctolagus cuniculus
100733907 Cavia porcellus
397323 Sus scrofa
407142 Bos taurus
100860743 Capra hircus
403826 Canis lupus familiaris
100196905 Ovis aries
397738 Xenopus laevis
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