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Collagen, Type II, alpha 1 Proteins (COL2A1)

COL2A1 encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Additionally we are shipping COL2A1 Antibodies (71) and COL2A1 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL2A1 12824 P28481
COL2A1 1280 P02458
Rat COL2A1 COL2A1 25412 P05539
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Top COL2A1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$777.70
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,245.83
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$584.38
Details
HOST_Cow Cow Un-conjugated   0.5 mg Log in to see 6 to 11 Days
$728.57
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details

COL2A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

Top referenced COL2A1 Proteins

  1. Human COL2A1 Protein expressed in Human Cells - ABIN2004775 : Ala-Kokko, Kvist, Metsäranta, Kivirikko, de Crombrugghe, Prockop, Vuorio: Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1). in The Biochemical journal 1997 (PubMed)
    Show all 5 references for ABIN2004775

More Proteins for Collagen, Type II, alpha 1 (COL2A1) Interaction Partners

Horse (Equine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. In contrast to previous studies using C2C the present study demonstrated that synovial levels of Coll2 (show SEMA3D Proteins)-1 were significantly elevated in tarsocrural joints affected with osteochondrosis

  2. These results suggested that serum and synovial fluid (SF) collagen type II (CTX (show VSIG1 Proteins)-II) concentrations and SF:serum CTX (show VSIG1 Proteins)-II ratio may be used to detect cartilage degradation in horses with joint injury.

Rabbit Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. The expression of II type collagen and MMP-7 (show MMP7 Proteins) is correlated to a retrogression of acetabular cartilage and increases obviously in early developmental dysplasia. [MMP7 (show MMP7 Proteins)]

Mouse (Murine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Col2 expression was seen in the prehypertrophic zone of the mandibular condyle cartilage.

  2. Rspo2 (show RSPO2 Proteins) activates Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling to reduce Col2a1 and Sox9 (show SOX9 Proteins) and to facilitate differentiation of proliferating chondrocytes into hypertrophic chondrocytes in growth cartilage

  3. The MC13 mutation in Col2a1 causes an incompletely penetrant splicing defect.

  4. The mutant G1170S Col2a1 gene in mice clearly alters the transgenic murine phenotype and cartilage matrix homeostasis.

  5. Data indicate that tamoxifen decreased collage type II COL2A1 by activating matrix metallopeptidases MMP-2 (show MMP2 Proteins)/13 expression.

  6. The increased expressions of the cartilage-associated proteins Collagen2 and alpha-SMA (show SMN1 Proteins) during scleral chondrogenesis accompany myopia development.

  7. Results indicate the ability of type II collagen (CII) to generate CII-specific anterior chamber-associated immune deviation (ACAID)-mediated immune tolerance in vivo and in vitro in both DBA/1 (show RPS19 Proteins) mice and C57BL/6 mice.

  8. expression of the Col2a1 IIC splice form may have a regulatory function in controlling alternative splicing of exon 2 to generate defined proportions of IIA, IID and IIB procollagen isoforms during cartilage development

  9. regulates Mac-1 (show ITGAM Proteins)-mediated complement-dependent phagocytosis

  10. characterization of the Col2a1(+ex2) mice has surprisingly shown that disruption of alternative splicing does not affect overt cartilage formation

Human Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Dysspondyloenchondromatosis is associated with COL2A1 mutation.

  2. Constitutive mutation in COL2A1 gene is associated with Kniest dysplasia and chondrosarcoma.

  3. Serum CTX (show CYP27A1 Proteins)-II levels in human brucellosis were higher than those of healthy controls but serum CTX (show CYP27A1 Proteins)-II levels in male patients were significantly higher than those of female patients indicating biological changes in cartilage and bone in human brucellosis.

  4. Results identified a novel COL2A1 variant (c.619G>A, p.Gly207Arg) causing a distinct type II collagenopathy with features of progressive pseudorheumatoid dysplasia and spondyloepiphyseal dysplasia, Stanescu type.

  5. estimated median of 95 months as compared to an estimated median of 16 months for subjects expressing other levels of COL2A1 and SLC6A10P

  6. a novel mutation, c.620G>A (p.Gly207Glu), in the collagen type II alpha-1 gene; genotype-phenotype relationship between mutations and clinical findings of Spondyloepiphyseal dysplasia congenita

  7. Identified is a novel Col2a1 mutant mouse possessing a p.Tyr1391Ser missense mutation. Endoplasmic reticulum stress-mediated apoptosis contributes to a skeletal dysplasia resembling platyspondylic lethal skeletal dysplasia, Torrance type, in this line.

  8. A unique case of spondyloepiphyseal dysplasia congenita with mild coxa vara caused by double de novo COL2A1 mutations (p.G504S, p.G612A) located on the same allele.

  9. This study demonstrated that Genes overexpressed in Pilomyxoid Astrocytoma vs. Pilocytic Astrocytoma, ranked according to fold-change, included developmental genes H19 (show NCKAP1 Proteins), DACT2 (show DACT2 Proteins),COL2A1; COL1A1 (show COL1A1 Proteins) and IMP3 (show IGF2BP3 Proteins).

  10. c.2224G>A (p.Gly687Ser) is a novel mutation of COL2A1 associated with spondyloepiphyseal dysplasia congenital.

Pig (Porcine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Data suggest that focal adhesion kinase (FAK)-SMAD 2/3 mediate signal crosstalk between type II collagen and TGF-beta1 and regulate glycosaminoglycan secretion in chondrocytic cells.

Cow (Bovine) Collagen, Type II, alpha 1 (COL2A1) interaction partners

  1. Denaturation of the chimeric collagen increased its affinity for fibronectin (show FN1 Proteins), as seen for mammalian collagens.

  2. Data show that expression of mRNAs for aggrecan (show ACAN Proteins), collagen type II, and versican (show Vcan Proteins) were significantly effected by the intervention.

  3. Data show that biglycan (show BGN Proteins), collagen type I, collagen type II, decorin (show DCN Proteins), and versican (show Vcan Proteins) were significantly affected by vibration duration, frequency, and amplitude.

  4. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V

  5. Changes in aggrecan (show ACAN Proteins) and type II collagen promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations.

  6. SMase down-regulates type II collagen in articular chondrocytes via activation of the ERK signaling cascade, redistribution of SOX9, and recruitment of c-Fos

  7. Response of the chondrocyte to a cryptic sequence of denaturated type II collagen may play a role in naturally occurring hypertrophy in endochondral ossification and in the development of cartilage pathology in osteoarthritis.

  8. IGF-I (show IGF1 Proteins) dose-dependently maintained cartilage formation

COL2A1 Protein Profile

Protein Summary

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Gene names and symbols associated with COL2A1

  • collagen, type II, alpha 1 (col2a1)
  • collagen, type II, alpha 1 (col2a1b)
  • collagen, type II, alpha 1 (COL2A1)
  • collagen, type II, alpha 1 (Col2a1)
  • type II Collagen (LOC100009005)
  • ANFH protein
  • AOM protein
  • CB11 protein
  • CG2A1A protein
  • Col2 protein
  • Col2a protein
  • Col2a-1 protein
  • COL2A1 protein
  • col2a1a protein
  • COL11A3 protein
  • COLLII protein
  • Del1 protein
  • Dmm protein
  • Lpk protein
  • M100856 protein
  • Rgsc856 protein
  • SEDC protein

Protein level used designations for COL2A1

alpha-1 type II collagen , collagen alpha-1(II) chain , alpha-1 type II' collagen , collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) , collagen, type II, alpha 1 , collagen alpha-1(II) chain-like , type II collagen , collagen type IIA , chondrocalcin , disproportionate micromelia , procollagen, type II, alpha 1 , cartilage collagen , collagen II, alpha-1 polypeptide , alpha 1 type II procollagen , alpha 1 type IIA collagen , procollagen alpha 1(II) , Procollagen II alpha 1 , collagen type II (Col2A1) gene, enhancer region , pro alpha1 type II collagen , collagen type II , type II collagen alpha1 , cyanogen bromide , pro-alpha 1(II)

GENE ID SPECIES
394828 Xenopus (Silurana) tropicalis
397739 Xenopus laevis
451860 Pan troglodytes
100433193 Pongo abelii
100474711 Ailuropoda melanoleuca
791241 Equus caballus
100008672 Oryctolagus cuniculus
100588525 Nomascus leucogenys
12824 Mus musculus
1280 Homo sapiens
395069 Gallus gallus
25412 Rattus norvegicus
100009005 Oryctolagus cuniculus
100733907 Cavia porcellus
397323 Sus scrofa
407142 Bos taurus
100860743 Capra hircus
403826 Canis lupus familiaris
100196905 Ovis aries
397738 Xenopus laevis
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