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Collagen, Type IV, alpha 1 Proteins (COL4A1)

COL4A1 encodes the major type IV alpha collagen chain of basement membranes. Additionally we are shipping COL4A1 Antibodies (45) and COL4A1 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL4A1 1282 P02462
COL4A1 12826 P02463
Rat COL4A1 COL4A1 290905  
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Top COL4A1 Proteins at antibodies-online.com

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$310.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,014.95
Details

COL4A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human
,
Mouse (Murine)

More Proteins for Collagen, Type IV, alpha 1 (COL4A1) Interaction Partners

Zebrafish Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. the shiomaneki (sio) gene locus encodes Col4a6 (show COL4a6 Proteins), a subunit of type IV collagen (show COL4 Proteins), which, in a complex with Col4a5, is a basement membrane (BM) component. Both col4a5 and col4a6 (show COL4a6 Proteins) mutants displayed similar abnormalities in the axogenesis

  2. During motor axon regeneration, col4a5 destabilizes axons probing inappropriate trajectories to ensure target-selective regeneration, possible through slit1a.

  3. Genetic and biochemical studies indicate that Slit binds to Dragnet (Col4a5) which forms the basement membrane on the surface of the tectum.

Human Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. High serum Collagen Type IV (show COL4 Proteins) is associated with ovarian and breast cancer.

  2. Hydroxylation and O-linked glycosylation sites in col4a1 from human lens capsule.

  3. SMAD3 (show SMAD3 Proteins) is a necessary factor for TGFbeta (show TGFB1 Proteins)-mediated stimulation of mRNA and protein expression of type IV collagen (show COL4 Proteins) genes in human vascular smooth muscle cells; it regulates expression of COL4a1 and COL4a2 (show COL4a2 Proteins)

  4. COLIV is a promising tumour marker for CLM and can possibly be used to detect postoperative CLM recurrence. The combination of COLIV and CEA is superior to either marker alone in detecting CLM

  5. analysis of the unique AAB composition and chain register for a heterotrimeric type IV collagen (show COL4 Proteins) model peptide COL4a1/COL4a2 (show COL4a2 Proteins) containing a natural interruption site

  6. Studied the role of alpha1 and alpha2 chains of type IV collagen (show COL4 Proteins) in UIP; found type IV collagen (show COL4 Proteins) deposition in early fibrotic lesions of UIP may be implicated in refractory pathophysiology including migration of lesion fibroblasts via a FAK (show PTK2 Proteins) pathway.

  7. The expression of collagen type IV (show COL4 Proteins) and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

  8. Attenuation of lysyl oxidase (show LOX Proteins) and collagen gene expression in keratoconus patient corneal epithelium corresponds to disease severity.

  9. Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A (show PDGFA Proteins)), a potent chemotactic factor for fibroblasts.

  10. A girl with porencephaly and an episode of microangiopathic hemolysis in infancy and her father with HANAC, both of whom had a heterozygous missense mutation of COL4A1, are reported.

Mouse (Murine) Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. data show that both basement membrane defects and ER stress contribute to Col4a1 renal disease, which has important implications for the development of treatment strategies for collagenopathies

  2. Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A (show PDGFA Proteins)), a potent chemotactic factor for fibroblasts.

  3. Col4a1 mutations cause abnormal vascular development, which triggers small-vessel disease, recurrent hemorrhagic strokes, and age-related macroangiopathy.

  4. Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 (show LIN28A Proteins) upregulates collagen expression in glomerular mesangial cells from diabetic mice.

  5. COL4A1 and COL4A2 (show COL4a2 Proteins) mutations are pleiotropic and cause a wide spectrum of disorders, including ocular dysgenesis, brain malformations and myopathy, of variable severity in both mice and humans.

  6. WT1 (show WT1 Proteins) maintains testicular cord integrity by additively regulating the expression of basal lamina components Col4a1 and Col4a2 (show COL4a2 Proteins) with SOX9 (show SOX9 Proteins).

  7. show that heterozygous Col4a1 mutant mice have ocular dysgenesis, neuronal localization defects, and myopathy characteristic of Muscle-eye-brain disease/Walker-Warburg syndrome

  8. Data suggest that podocyte von Hippel-Lindau protein (show VHLL Proteins) is required for normal maintenance of podocytes, basment membrane collagen {alpha}1{alpha}2{alpha}1(IV) deposition and ultrastructure, neuroglobin (show NGB Proteins) experssion and glomerular barrier properties.

  9. Mutations in COL4A1 result in a complex vascular phenotype encompassing defects in maintenance of vascular tone, endothelial cell function and blood pressure regulation.

  10. Collagen type IV (show COL4 Proteins) and Perlecan (show HSPG2 Proteins) exhibit dynamic localization in the Allantoic Core Domain.

Cow (Bovine) Collagen, Type IV, alpha 1 (COL4A1) interaction partners

  1. High shear stress up-regulates type IV collagen (show COL4 Proteins) synthesis and down-regulates MMP-2 (show MMP2 Proteins) secretion in endothelial cells.

  2. alpha1.alpha2 stabilize the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys (show LYZ Proteins) cross-links

COL4A1 Protein Profile

Protein Summary

This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Gene names and symbols associated with COL4A1

  • collagen, type IV, alpha 5 (Alport syndrome) (col4a5)
  • collagen, type IV, alpha 1 (COL4A1)
  • collagen, type IV, alpha 1 (LOC100224679)
  • collagen, type IV, alpha 1 (Col4a1)
  • arresten protein
  • Bru protein
  • Col4a-1 protein
  • col4a1 protein
  • Del(8)44H protein
  • HANAC protein
  • ICH protein
  • POREN1 protein
  • Raw protein
  • Svc protein
  • wu:fc02g11 protein

Protein level used designations for COL4A1

collagen alpha-5(IV) chain , drg , dragnet , type IV collagen alpha 1 , collagen, type IV, alpha 1 , collagen type IV alpha 1 chain , collagen alpha-1(IV) chain-like , COL4A1 NC1 domain , collagen IV, alpha-1 polypeptide , collagen alpha-1(IV) chain , collagen of basement membrane, alpha-1 chain , Del(8)Bru44H , alpha1(IV) collagen , procollagen, type IV, alpha 1 , retinal anterior wiring , alpha 1 type IV collagen , collagen IV a1 chain

GENE ID SPECIES
323561 Danio rerio
403496 Canis lupus familiaris
700281 Macaca mulatta
100478752 Ailuropoda melanoleuca
100224679 Taeniopygia guttata
1282 Homo sapiens
12826 Mus musculus
282191 Bos taurus
290905 Rattus norvegicus
395530 Gallus gallus
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