Collagen, Type IV, alpha 2 Proteins (COL4a2)

COL4a2 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Additionally we are shipping COL4a2 Antibodies (57) and COL4a2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL4a2 1284 P08572
COL4a2 12827 P08122
Rat COL4a2 COL4a2 306628  
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Top COL4a2 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$669.00
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 13 to 16 Days
$242.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 11 to 18 Days
$873.13
Details

COL4a2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Collagen, Type IV, alpha 2 (COL4a2) Interaction Partners

Human Collagen, Type IV, alpha 2 (COL4a2) interaction partners

  1. COL4A2 expression is significantly upregulated in human masticatory mucosa during wound healing

  2. These results indicate that the CHD (show CHDH Proteins)-related genetic variant at the COL4A2 locus affects COL4A2/COL4A1 (show COL4A1 Proteins) expression, smooth muscle cells survival, and atherosclerotic plaque stability, providing a mechanistic explanation for the association between the genetic variant and CHD (show CHDH Proteins) risk.

  3. Expression of miR (show MLXIP Proteins)-26a and miR (show MLXIP Proteins)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 Proteins), ATP1B1 (show ATP1B1 Proteins), COL4A2, CPEB3 (show CPEB3 Proteins), CDK6 (show CDK6 Proteins), DNMT3a (show DNMT3A Proteins) and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.

  4. identified a novel COL4A2 (c.2399G>A, p.G800E, CCDS41907.1) mutation in an autosomal dominant family with porencephaly and ocular abnormalities

  5. No significant change in canstatin levels was observed between normotensive and pre-eclampsia patients.

  6. SMAD3 (show SMAD3 Proteins) is a necessary factor for TGFbeta (show TGFB1 Proteins)-mediated stimulation of mRNA and protein expression of type IV collagen (show COL4 Proteins) genes in human vascular smooth muscle cells; it regulates expression of COL4a1 (show COL4A1 Proteins) and COL4a2

  7. analysis of the unique AAB composition and chain register for a heterotrimeric type IV collagen (show COL4 Proteins) model peptide COL4a1 (show COL4A1 Proteins)/COL4a2 containing a natural interruption site

  8. Studied the role of alpha1 and alpha2 chains of type IV collagen (show COL4 Proteins) in UIP; found type IV collagen (show COL4 Proteins) deposition in early fibrotic lesions of UIP may be implicated in refractory pathophysiology including migration of lesion fibroblasts via a FAK (show PTK2 Proteins) pathway.

  9. Reduction of COL4A2 expression by RNAI-mediated knockdown induces cell death. Finally, elevated Notch3 (show NOTCH3 Proteins) expression levels correlate with higher COL4A2 expression in human ovarian tumor specimens

  10. The expression of collagen type IV (show COL4 Proteins) and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

Mouse (Murine) Collagen, Type IV, alpha 2 (COL4a2) interaction partners

  1. COL4A1 (show COL4A1 Proteins) and COL4A2 mutations are pleiotropic and cause a wide spectrum of disorders, including ocular dysgenesis, brain malformations and myopathy, of variable severity in both mice and humans.

  2. WT1 (show WT1 Proteins) maintains testicular cord integrity by additively regulating the expression of basal lamina components Col4a1 (show COL4A1 Proteins) and Col4a2 with SOX9 (show SOX9 Proteins).

  3. Data suggest that podocyte von Hippel-Lindau protein (show VHLL Proteins) is required for normal maintenance of podocytes, basment membrane collagen {alpha}1{alpha}2{alpha}1(IV) deposition and ultrastructure, neuroglobin (show NGB Proteins) experssion and glomerular barrier properties.

  4. In murine embryos, collagen IV (show COL4 Proteins) subunits alpha1(IV), alpha2(IV), alpha5(IV) and alpha6(IV) were detected in the basement membrane surrounding the lens vesicle, and they persisted in the capsule until adulthood.

  5. The genetic, molecular, and phenotypic characterization of nine Col4a1 (show COL4A1 Proteins) and three Col4a2 missense mutations recovered in random mutagenesis experiments in the mouse, are presented.

  6. Foxc2 (show FOXC2 Proteins) plays an important role in the development of the mesenchyme through the regulation of MyoD (show MYOD1 Proteins) gene expression but does not regulate Collagen type IV alpha 1 (Col4a1 (show COL4A1 Proteins)) or Col4a2

  7. These results indicate that SOX9 (show SOX9 Proteins) is essential for Col4a2 expression in mesangial cells and might be involved in the accumulation of alpha2(IV) collagen in experimental nephritis.

Cow (Bovine) Collagen, Type IV, alpha 2 (COL4a2) interaction partners

  1. Results describe the molecular mechanism underlying chain selection in the assembly of collagen IV (show COL4 Proteins), and the kinetics of interaction and assembly of the alpha1(IV) and alpha2(IV) NC1 domains.

COL4a2 Protein Profile

Protein Summary

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.

Gene names and symbols associated with COL4a2

  • collagen, type IV, alpha 2 (col4a2)
  • collagen, type IV, alpha 2 (COL4A2)
  • collagen, type IV, alpha 2 (Col4a2)
  • Col4a-2 protein
  • col4a2-a protein
  • ICH protein
  • POREN2 protein
  • zCanstatin protein

Protein level used designations for COL4a2

collagen, type IV, alpha 2 , collagen alpha2(IV) , collagen type IV alpha 2 chain , alpha 2 type IV collagen , type IV collagen alpha 2 chain , collagen alpha-2(IV) chain-like , canstatin , collagen alpha-2(IV) chain , procollagen, type IV, alpha 2 , alpha-2 collagen type IV

GENE ID SPECIES
373763 Xenopus laevis
403843 Canis lupus familiaris
418752 Gallus gallus
452661 Pan troglodytes
553355 Danio rerio
100153454 Sus scrofa
100429807 Macaca mulatta
100486079 Xenopus (Silurana) tropicalis
1284 Homo sapiens
12827 Mus musculus
306628 Rattus norvegicus
508632 Bos taurus
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