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Collagen, Type IV, alpha 3 (Goodpasture Antigen) Binding Protein Proteins (COL4A3BP)

COL4A3BP encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Additionally we are shipping COL4A3BP Antibodies (91) and COL4A3BP Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL4A3BP 10087 Q9Y5P4
COL4A3BP 68018 Q9EQG9
Rat COL4A3BP COL4A3BP 365652  
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Top COL4A3BP Proteins at antibodies-online.com

Showing 9 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details
Human Un-conjugated   5 μg Log in to see 6 Days
$168.54
Details

COL4A3BP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced COL4A3BP Proteins

  1. Human COL4A3BP Protein expressed in Baculovirus infected Insect Cells - ABIN2006138 : Granero, Revert, Revert-Ros, Lainez, Martínez-Martínez, Saus: A human-specific TNF-responsive promoter for Goodpasture antigen-binding protein. in The FEBS journal 2005 (PubMed)

  2. Human COL4A3BP Protein expressed in Escherichia coli (E. coli) - ABIN667012 : Turner, Mason, Brown, Fox, Povey, Rees, Pusey: Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen. in The Journal of clinical investigation 1992 (PubMed)

More Proteins for Collagen, Type IV, alpha 3 (Goodpasture Antigen) Binding Protein (COL4A3BP) Interaction Partners

Zebrafish Collagen, Type IV, alpha 3 (Goodpasture Antigen) Binding Protein (COL4A3BP) interaction partners

  1. study found both GPBP isoforms are expressed during early development &, when depleted, lead to apoptosis; results suggest GPBP is an important factor for normal skeletal muscle & brain development

Human Collagen, Type IV, alpha 3 (Goodpasture Antigen) Binding Protein (COL4A3BP) interaction partners

  1. phosphorylation of CERT at the FFAT motif-adjacent serine affects its affinity for VAP (show F10 Proteins), which may regulate the inter-organelle trafficking of ceramide in response to the perturbation of cellular sphingomyelin and/or other sphingolipids

  2. Both CERT isoforms, when immobilized, bind the globular head region of C1q and initiate the classical complement pathway. C1q binds endogenous CERTL on the surface of apoptotic cells.

  3. Structural basis for the Golgi association by the pleckstrin (show PLEK Proteins) homology domain of the ceramide trafficking protein (CERT)

  4. CERT is at a convergence point of non-vesicular and vesicular transport processes and plays a central role within the PKD (show PRKD1 Proteins) signaling network at the Golgi complex. (Review)

  5. Loss of the ceramide transfer protein augments EGF receptor (show EGFR Proteins) signaling in breast cancer.

  6. The START domain in GPBP is important for this interaction. SAP (show APCS Proteins) and GPBP form complexes in blood and partly colocalize in amyloid plaques from Alzheimer disease patients.

  7. This review is focused on ceramide transfer protein (CERT) as a major regulator of ceramide flux in the cell. [review]

  8. during cellular stress, disassembly of Golgi structure together with inactivation of CERT by caspases causes a reduction in ceramide trafficking and sphingomyelin synthesis, and could contribute to the cellular response to pro-apoptotic stress

  9. the presence of IncD, CERT, VAPA (show VAPA Proteins)/B, and potentially additional host and/or bacterial factors, at points of contact between the ER and the inclusion membrane provides a specialized microenvironment favorable to bacterial development.

  10. We hypothesize that sphingomyelin acquired by CERT-dependent transport of ceramide and subsequent conversion to SM is necessary for C. trachomatis replication whereas SM acquired by GBF1-dependent pathway is essential for inclusion growth and stability.

Mouse (Murine) Collagen, Type IV, alpha 3 (Goodpasture Antigen) Binding Protein (COL4A3BP) interaction partners

  1. CERT protein deficiency compromises mitochondrial function and leads to senescence in primary cells.

  2. knockdown of CERT alone was not sufficient to increase young oocyte's susceptibility to death

  3. GPBP directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein

  4. VEGF (show VEGFA Proteins) inhibitor also partially prevented the stimulation of alpha3(IV (show COL4a3 Proteins)) collagen by transforming growth factor (TGF)-beta1 (show TGFB1 Proteins).

  5. CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus.

  6. CERT can attenuate a key metabolic protective mechanism against ceramide-induced apoptosis in keratinocytes

  7. CERT is an essential gene for mouse development and embryonic survival and is critical for mitochondrial integrity.

COL4A3BP Protein Profile

Protein Summary

This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with COL4A3BP

  • collagen, type I, alpha 2 (col1a2)
  • collagen, type IV, alpha 3 (Goodpasture antigen) binding protein (COL4A3BP)
  • collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a (col4a3bpa)
  • collagen, type IV, alpha 3 (Goodpasture antigen) binding protein (Col4a3bp)
  • collagen, type IV, alpha 3 (Goodpasture antigen) binding protein (col4a3bp)
  • 2810404O15Rik protein
  • 9230101K08Rik protein
  • alpha2(I) protein
  • AU016711 protein
  • cert protein
  • certl protein
  • cetp protein
  • col4a3bp protein
  • gpbp protein
  • hm:zehn2357 protein
  • stard11 protein
  • wu:fa98d05 protein
  • wu:fa99g10 protein
  • wu:fb04c08 protein
  • wu:fb11d06 protein
  • wu:fc37f11 protein
  • zehn2357 protein
  • zgc:92147 protein

Protein level used designations for COL4A3BP

collagen alpha-2(I) chain , collagen, type IV, alpha 3 (Goodpasture antigen) binding protein , alpha 3 type IV collagen binding protein , WITHDRAWN:zgc:92147 , ceramide transfer protein , cert , collagen type IV alpha-3-binding protein , goodpasture antigen-binding protein , StAR-related lipid transfer (START) domain containing 11 , ceramide transporter , hCERT , lipid-transfer protein CERTL , START domain-containing protein 11 , ceramide transport protein , procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein , stAR-related lipid transfer protein 11 , stARD11 , collagen, type IV, alpha 3 binding protein , GPBP

GENE ID SPECIES
550627 Danio rerio
471515 Pan troglodytes
796455 Danio rerio
10087 Homo sapiens
68018 Mus musculus
432007 Xenopus laevis
427209 Gallus gallus
612799 Canis lupus familiaris
286797 Bos taurus
365652 Rattus norvegicus
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