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COL4A3BP encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Additionally we are shipping COL4A3BP Proteins (12) and COL4A3BP Kits (9) and many more products for this protein.
Showing 10 out of 105 products:
Human Polyclonal COL4A3BP Primary Antibody for ELISA, WB - ABIN451598
Kudo, Kumagai, Tomishige, Yamaji, Wakatsuki, Nishijima, Hanada, Kato: Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. in Proceedings of the National Academy of Sciences of the United States of America 2008
Human Polyclonal COL4A3BP Primary Antibody for ELISA, WB - ABIN4299569
Swanton, Marani, Pardo, Warne, Kelly, Sahai, Elustondo, Chang, Temple, Ahmed, Brenton, Downward, Nicke: Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. in Cancer cell 2007
study found both GPBP isoforms are expressed during early development &, when depleted, lead to apoptosis; results suggest GPBP is an important factor for normal skeletal muscle & brain development
Data suggest that isolated PH and START domains of CERT interact with each other; START domain binds to PH domain at same site for PtdInsP-binding; mutations disrupting PH-START interaction increase both PtdInsP-binding affinity and ceramide transfer activity. (PH domain = N-terminal pleckstrin (show PLEK Antibodies) homology domain; START domain = StAR-related lipid transfer domain; PtdInsP = phosphatidylinositol 4-phosphate)
Cells expressing mitoCERT import ceramides into mitochondria and undergo Bax (show BAX Antibodies)-dependent apoptosis.
phosphorylation of CERT at the FFAT motif-adjacent serine affects its affinity for VAP (show F10 Antibodies), which may regulate the inter-organelle trafficking of ceramide in response to the perturbation of cellular sphingomyelin and/or other sphingolipids
Both CERT isoforms, when immobilized, bind the globular head region of C1q and initiate the classical complement pathway. C1q binds endogenous CERTL on the surface of apoptotic cells.
Structural basis for the Golgi association by the pleckstrin (show PLEK Antibodies) homology domain of the ceramide trafficking protein (CERT)
CERT is at a convergence point of non-vesicular and vesicular transport processes and plays a central role within the PKD (show PRKD1 Antibodies) signaling network at the Golgi complex. (Review)
Loss of the ceramide transfer protein augments EGF receptor (show EGFR Antibodies) signaling in breast cancer.
The START domain in GPBP is important for this interaction. SAP (show APCS Antibodies) and GPBP form complexes in blood and partly colocalize in amyloid plaques from Alzheimer disease patients.
This review is focused on ceramide transfer protein (CERT) as a major regulator of ceramide flux in the cell. [review]
during cellular stress, disassembly of Golgi structure together with inactivation of CERT by caspases causes a reduction in ceramide trafficking and sphingomyelin synthesis, and could contribute to the cellular response to pro-apoptotic stress
CERT protein deficiency compromises mitochondrial function and leads to senescence in primary cells.
knockdown of CERT alone was not sufficient to increase young oocyte's susceptibility to death
GPBP directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein (show FILIP1L Antibodies)
VEGF (show VEGFA Antibodies) inhibitor also partially prevented the stimulation of alpha3(IV (show COL4a3 Antibodies)) collagen by transforming growth factor (TGF)-beta1 (show TGFB1 Antibodies).
CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus.
CERT can attenuate a key metabolic protective mechanism against ceramide-induced apoptosis in keratinocytes
CERT is an essential gene for mouse development and embryonic survival and is critical for mitochondrial integrity.
This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.
collagen alpha-2(I) chain
, collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
, alpha 3 type IV collagen binding protein
, ceramide transfer protein
, collagen type IV alpha-3-binding protein
, goodpasture antigen-binding protein
, StAR-related lipid transfer (START) domain containing 11
, ceramide transporter
, lipid-transfer protein CERTL
, START domain-containing protein 11
, ceramide transport protein
, procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
, stAR-related lipid transfer protein 11
, collagen, type IV, alpha 3 binding protein