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Collagen, Type IV, alpha 5 Proteins (COL4a5)

COL4a5 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Additionally we are shipping COL4a5 Antibodies (27) and COL4a5 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL4a5 1287 P29400
Mouse COL4a5 COL4a5 12830  
Rat COL4a5 COL4a5 363457  
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Top COL4a5 Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$422.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$605.82
Details

COL4a5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

More Proteins for Collagen, Type IV, alpha 5 (COL4a5) Interaction Partners

Human Collagen, Type IV, alpha 5 (COL4a5) interaction partners

  1. Coinheritance of COL4A5 and MYO1E (show MYO1E Proteins) mutations accentuate the severity of kidney disease.

  2. Case Report: subepidermal blistering disease with autoantibodies to multiple laminin subunits which developed autoantibodies to COL4A5 associated with membranous glomerulonephropathy.

  3. New COL4A5 mutations among Portuguese patients with collagen IV (show COL4 Proteins)-related nephropathies were identified in unrelated individuals.

  4. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Proteins) DDR1 (show DDR1 Proteins)-mediated ERK (show EPHB2 Proteins) activation.

  5. we identified seven families with associated mutations in COL4A3 (show COL4a3 Proteins) and COL4A4 genes and four families with associated mutations in COL4A4 and COL4A5. We did not find kindreds with digenic inheritance attributable to mutations in COL4A3 (show COL4a3 Proteins) and COL4A5

  6. The expression of collagen type IV (show COL4 Proteins) and its alpha chains (alpha1-6) was investigated in different endothelial cell culture systems in vitro qualitatively and quantitatively.

  7. New deletion in COL4A6 (show COL4a6 Proteins)/COL4A5 related to diffuse esophageal leiomyomatosis associated with Alport syndrome in a Chinese family.

  8. We identified a nucleotide change 1226 G>A, causing amino acid substitutions of Gly to Asp (show ASIP Proteins) at position 409, in hemizygosis in the exon 20 of COL4A5 gene (proband 16 and the 13 in Alport syndrome pedigree

  9. the intima+media of IPAH vessels, collagens (COL4A5, COL14A1 (show COL14A1 Proteins), and COL18A1 (show COL18A1 Proteins)), matrix metalloproteinase (show MMP20 Proteins) (MMP) 19 (show MMP19 Proteins), and a disintegrin and metalloprotease (show ADAM8 Proteins) (ADAM) 33 (show ADAM33 Proteins) were higher expressed, whereas MMP10 (show MMP10 Proteins), ADAM17 (show ADAM17 Proteins), TIMP1 (show TIMP1 Proteins), and TIMP3 (show TIMP3 Proteins) were less abundant.

  10. 31 mutation in COL4A5 associated with autosomal dominant Alport syndrome.

Mouse (Murine) Collagen, Type IV, alpha 5 (COL4a5) interaction partners

  1. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor (show ITGA2 Proteins) DDR1 (show DDR1 Proteins)-mediated ERK (show EPHB2 Proteins) activation.

  2. In murine embryos, collagen IV (show COL4 Proteins) subunits alpha1(IV), alpha2(IV), alpha5(IV) and alpha6(IV) were detected in the basement membrane surrounding the lens vesicle, and they persisted in the capsule until adulthood.

  3. In kidney, when expressed onto Col4a3 (show COL4a3 Proteins)(-/-) background, human alpha3(IV (show COL4a3 Proteins)) chain restored expression of and co-assembled with mouse alpha4 and alpha5(IV) chains at sites where human alpha3(IV (show COL4a3 Proteins)) was expressed. All three chains required for network assembly.

  4. Alpha3(IV (show COL4a3 Proteins)), alpha4(IV), and alpha5(IV) chains form a complex, which is a heterotrimer, and a defect in complex formation might be one of the molecular mechanisms underlying the pathogenesis of Alport syndrome.

  5. the proximal bifunctional promoter regulates the expression of the alpha5(IV) and alpha6(IV) genes in a cell-specific manner and demonstrates promoter plasticity in growth factor regulation of type IV collagen (show COL4 Proteins) genes in different tissues of the body.

COL4a5 Protein Profile

Protein Summary

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene.

Gene names and symbols associated with COL4a5

  • collagen, type IV, alpha 5 (COL4A5)
  • collagen, type IV, alpha 1 (col4a1)
  • collagen, type IV, alpha 5 (LOC100285389)
  • collagen, type IV, alpha 5 (Col4a5)
  • ASLN protein
  • ATS protein
  • CA54 protein
  • col4a5 protein
  • fj65e07 protein
  • im:7157877 protein
  • RGD1565499 protein
  • si:ch211-174g17.1 protein
  • wu:fj65e07 protein

Protein level used designations for COL4a5

collagen, type IV, alpha 5 , type IV collagen alpha 5-like , type IV collagen alpha 5 chain , collagen alpha-5(IV) chain-like , collagen IV, alpha-5 polypeptide , collagen alpha-5(IV) chain , collagen of basement membrane, alpha-5 chain , dA149D17.3 , dA24A23.1 , collagen type IV alpha5 chain , procollagen type IV alpha 5 , procollagen, type IV, alpha 5 , collagen, type IV, alpha 5 (Alport syndrome) , type IV collagen alpha 5

GENE ID SPECIES
511602 Bos taurus
554269 Danio rerio
703814 Macaca mulatta
100519180 Sus scrofa
465805 Pan troglodytes
100285389 Zea mays
1287 Homo sapiens
12830 Mus musculus
363457 Rattus norvegicus
403466 Canis lupus familiaris
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