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Collagen, Type VIII, alpha 1 Proteins (COL8A1)

COL8A1 encodes one of the two alpha chains of type VIII collagen. Additionally we are shipping COL8A1 Antibodies (37) and COL8A1 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL8A1 12837 Q00780
COL8A1 304021  
COL8A1 1295 P27658
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Top COL8A1 Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$1,408.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$563.20
Details
HOST_Escherichia coli (E. coli) Rabbit His tag   100 μg Log in to see 11 to 13 Days
$726.00
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$598.40
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$747.45
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$778.92
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$1,565.70
Details

COL8A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human

More Proteins for Collagen, Type VIII, alpha 1 (COL8A1) Interaction Partners

Mouse (Murine) Collagen, Type VIII, alpha 1 (COL8A1) interaction partners

  1. Lack of collagen VIII (show COX8A Proteins) reduces myofibroblast differentiation and fibrosis and promotes early mortality and left ventricle dilatation in response to pressure overload in mice.

  2. Type VIII (show COX8A Proteins) collagen signals via beta1 integrin and RhoA (show RHOA Proteins) to regulate MMP-2 (show MMP2 Proteins) expression and smooth muscle cell migration.

  3. Type VIII (show COX8A Proteins) collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.

  4. in contrast to diabetic wild-type mice EMT (show ITK Proteins)-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII (show COX8A Proteins) may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice

  5. Type VIII (show COX8A Proteins) collagen significantly modulates the effect of TGF-beta1 (show TGFB1 Proteins) on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy.

  6. Crystal structure of mouse alpha1(VIII (show COX8A Proteins))(3) NC1 domain trimer at 1.9 A resolution. Surface of collagen VIII (show COX8A Proteins) NC1 trimer has three strips of partially exposed aromatic residues, likely involved in supramolecular assemblies.

  7. These data indicate that type VIII (show COX8A Proteins) collagen plays an important role in glial scar formation during the repair process by astrocytes.

  8. Smooth muscle cells can modify the matrix microenvironment by producing type VIII (show COX8A Proteins) collagen, using it to overlay type I collagen, and generating a substrate favorable for migration

  9. Downregulation of COL8A1 expression sensitized hepatocarcinoma cells to the action of D-limonene, impeded cell proliferation, and led to decreased invasiveness, indicating that COL8A1 might serve as a target for gene therapy in hepatocarcinoma.

  10. Oxidized phospholipids induce type VIII (show COX8A Proteins) collagen expression and vascular smooth muscle cell migration.

Human Collagen, Type VIII, alpha 1 (COL8A1) interaction partners

  1. High COL8A1 expression is associated with early loss of kidney function.

  2. Data indicate that complement factor H (CFH (show CFH Proteins)) R1210C and common variants in COL8A1 and RAD51B (show Rad51B Proteins) plus six genes contribute predictive information for advanced macular degeneration (AMD (show AMD1 Proteins)) beyond macular and behavioral phenotypes.

  3. The results are consistent with the proposal that rare CNVs play a role in TS aetiology and suggest a possible role for rearrangements in the COL8A1 and NRXN1 (show NRXN1 Proteins) gene regions.

  4. In addition, eight genes classified as 'second tier' hits in the original study (PAX7 (show PAX7 Proteins), THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G (show GADD45G Proteins), NTN1 (show NTN1 Proteins), RBFOX3 (show RBFOX3 Proteins) and FOXE1 (show FOXE1 Proteins)) showed evidence of linkage and association in this replication sample.

  5. The purpose of this study is to evaluate COL8A1 and COL8A2 (show COL8a2 Proteins) as candidate genes for thin central corneal thickness in human primary open angle glaucoma patients.

  6. The absence of pathogenic mutations identified in the COL8A1 or COL8A2 (show COL8a2 Proteins) genes in affected members of 15 pedigrees with familial FECD (show COL8a2 Proteins) (Fuchs endothelial corneal dystrophy) indicates that other genetic factors are involved.

  7. The absence of pathogenic mutations in COL8A1 and COL8A2 (show COL8a2 Proteins) in patients with keratoconus indicates that other genetic factors are involved in the pathogenesis of this corneal ectatic disorder.

COL8A1 Protein Profile

Protein Summary

This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the same protein have been observed.

Gene names and symbols associated with COL8A1

  • collagen, type VIII, alpha 1 (COL8A1)
  • collagen, type VIII, alpha 1 (col8a1)
  • collagen, type VIII, alpha 1 (Col8a1)
  • C3orf7 protein
  • Col8a-1 protein
  • COL8A1 protein

Protein level used designations for COL8A1

collagen, type VIII, alpha 1 , collagen alpha-1(VIII) chain , procollagen type VIII alpha 1 , procollagen, type VIII, alpha 1 , cell proliferation-inducing protein 41 , collagen VIII, alpha-1 polypeptide , endothelial collagen , smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64 , alpha 1 type VIII collagen , collagen VIII , type VIII collagen alpha 1 chain

GENE ID SPECIES
460550 Pan troglodytes
494652 Xenopus laevis
100017530 Monodelphis domestica
100585226 Nomascus leucogenys
12837 Mus musculus
304021 Rattus norvegicus
1295 Homo sapiens
100009383 Oryctolagus cuniculus
100717829 Cavia porcellus
397430 Sus scrofa
418378 Gallus gallus
487950 Canis lupus familiaris
538564 Bos taurus
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