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Collagen, Type VIII, alpha 2 Proteins (COL8a2)

COL8a2 encodes the alpha 2 chain of type VIII collagen. Additionally we are shipping COL8a2 Antibodies (46) and COL8a2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL8a2 1296 P25067
COL8a2 329941 P25318
Rat COL8a2 COL8a2 313592  
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Top COL8a2 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$771.10
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$904.80
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$952.01
Details

COL8a2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Collagen, Type VIII, alpha 2 (COL8a2) Interaction Partners

Human Collagen, Type VIII, alpha 2 (COL8a2) interaction partners

  1. No mutations were identified in COL8A2, in neither the late-onset cohort nor the early-onset family, suggesting genetic heterogeneity in this Late-onset Fuchs endothelial corneal dystrophy (FECD) family.

  2. mutations in the COL8A2 gene do not contribute to all cases of early-onset early-onset Fuchs' endothelial corneal dystrophy .

  3. Variation in the COL8A2, SLC4A11, and ZEB1 genes is present in only a small fraction of African American cases and as such does not appear to significantly contribute to the genetic risk of Fuchs endothelial corneal dystrophy.

  4. Esophageal transcript profiling identified a distinct subset of genes, including COL8A2, in patients with Eosionophilic esophagitis and inherited connective tissue disorders.

  5. Association of central corneal thickness with TCF4 (show TCF4 Proteins) was also significant (p = 6.1x10(-7)), but was abolished with adjustment for FECD grade (p = 0.92).

  6. Single nucleotide polymorphisms in COL8A2 gene is not associated with central corneal thickness in glaucoma.

  7. Report cellular model in which collagen VIII (show COX8A Proteins) mutations, which clinically result in Fuchs' dystrophy, are associated with abnormal cellular accumulation of collagen VIII (show COX8A Proteins).

  8. The purpose of this study is to evaluate COL8A1 (show COL8A1 Proteins) and COL8A2 as candidate genes for thin central corneal thickness in human primary open angle glaucoma patients.

  9. These data constitute the first report of a heterozygous Q455V mutation of the COL8A2 gene in Korean patients with Fuchs' corneal dystrophy and Q455V may be the causative defect in the development and progression of Korean FECD patients.

  10. COL8A2, SLC4A11 (show SLC4A11 Proteins) genes may not be responsible for Fuchs endothelial corneal dystrophy in patients examined in this study.

Mouse (Murine) Collagen, Type VIII, alpha 2 (COL8a2) interaction partners

  1. Overexpression of the Col8a2 gene in mouse and human Fuchs endothelial corneal dystrophy endothelial cells suggested a role for altered autophagy in this disease.

  2. in contrast to diabetic wild-type mice EMT (show ITK Proteins)-like changes were attenuated in diabetic Col8alpha1/alpha2-KO mice, indicating that collagen VIII (show COX8A Proteins) may be 1 of the major inducers of epithelial-to-mesenchymal transition-like changes in kidneys of diabetic wild-type mice

  3. study confirms the Q455K substitution in the COL8A2 gene as being sufficient to cause FECD in the first mouse model of this disease and supports the role of the UPR and UPR-associated apoptosis in the pathogenesis of FECD caused by COL8A2 mutations

  4. Type VIII (show COX8A Proteins) collagen significantly modulates the effect of TGF-beta1 (show TGFB1 Proteins) on mesangial cells and may therefore play a role in the pathogenesis of diabetic nephropathy.

  5. Smooth muscle cells can modify the matrix microenvironment by producing type VIII (show COX8A Proteins) collagen, using it to overlay type I collagen, and generating a substrate favorable for migration

  6. Lack of type VIII (show COX8A Proteins) collagen confers renoprotection in diabetic nephropathy in a knockout mouse model.

  7. The mouse mutant Aca23 described here offers the first point mutation of the Col8a2 gene and suggests that a functional collagen VIII (show COX8A Proteins) alpha2 gene is essential for the correct assembly of the Descemet's membrane and for corneal stability.

COL8a2 Protein Profile

Protein Summary

This gene encodes the alpha 2 chain of type VIII collagen. The protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2.

Gene names and symbols associated with COL8a2

  • collagen, type VIII, alpha 2 (COL8A2)
  • collagen, type VIII, alpha 2 (Col8a2)
  • AI429819 protein
  • FECD protein
  • FECD1 protein
  • PPCD protein
  • PPCD2 protein

Protein level used designations for COL8a2

collagen, type VIII, alpha 2 , collagen alpha-2(VIII) chain , collagen VIII, alpha-2 polypeptide , collagen type VIII alpha 2 , dJ665N4.1 (collagen type VIII alpha 2) , endothelial collagen , procollagen type VIII alpha 2 , procollagen, type VIII, alpha 2

GENE ID SPECIES
428221 Gallus gallus
539415 Bos taurus
747856 Pan troglodytes
1296 Homo sapiens
329941 Mus musculus
313592 Rattus norvegicus
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