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COL16A1 encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Additionally we are shipping COL16A1 Proteins (3) and COL16A1 Kits (2) and many more products for this protein.
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Human Polyclonal COL16A1 Primary Antibody for IHC, ELISA - ABIN1534357
Gregory, Barlow, McLay, Kaul, Swarbreck, Dunham, Scott, Howe, Woodfine, Spencer, Jones, Gillson, Searle, Zhou, Kokocinski, McDonald, Evans, Phillips, Atkinson, Cooper, Jones, Hall, Andrews, Lloyd et al.: The DNA sequence and biological annotation of human chromosome 1. ... in Nature 2006
The NC11 domain of collagen XVI is a potential biomarker for oral squamous cell carcinoma and triggers vasculogenic mimicry via upregulation of endothelial receptors VEGFR1 (show FLT1 Antibodies), VEGFR2 (show KDR Antibodies) and uPAR (show PLAUR Antibodies).
collagen XVI plays a decisive role in the interaction of connective tissue cells with their ECM (show MMRN1 Antibodies), which is impaired in pathological situations
Gene expression profiles showed that COL16A1 was up-regulated in epidermolysis bullosa subtypes.
Overexpression of type XVI collagen in aberrant oral keratinocytes leads to Kindlin-1 (show FERMT1 Antibodies) induction, increased Kindlin-1 (show FERMT1 Antibodies)/beta1-integrin interaction, integrin activation and subsequently to a proliferative cellular phenotype.
Not in banded collagen fibrils in dermis, but is component of specialized fibrillin-1 (show FBN1 Antibodies)-containing microfibrils. In cartilage matrix not in aggregates with fibrillin-1 (show FBN1 Antibodies). Resides in thin, weakly banded collagen fibrils also containing collagens II and XI.
interacts with fibrillin-1 (show FBN1 Antibodies) and with fibronectin (show FN1 Antibodies) indicating multiple molecular interactions in which this ubiquitously expressed and versatile fibril-associated collagens with interrupted triple helices-collagen can participate
These results demonstrate de-novo expression of collagen XVI in glioblastomas as part of the tumor specific remodeling of the ECM (show MMRN1 Antibodies).
This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion.
procollagen, type XVI, alpha 1
, collagen, type XVI, alpha 1
, alpha 1 type XVI collagen
, collagen alpha-1(XVI) chain-like
, collagen XVI, alpha-1 polypeptide
, collagen alpha-1(XVI) chain
, [a]1 (XVI) collagen
, procollagen type XVI alpha 1