anti-Collagen, Type XVII, alpha 1 (COL17A1) Antibodies

COL17A1 encodes the alpha chain of type XVII collagen. Additionally we are shipping COL17A1 Kits (12) and COL17A1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat COL17A1 COL17A1 294027  
COL17A1 1308 Q9UMD9
COL17A1 12821 Q07563
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Top anti-COL17A1 Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB COL17A1 Antibody (Center) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. COL17A1 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COL17A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated EIA, IHC (fro), IF, WB 0.1 mg Log in to see 6 to 8 Days
$742.50
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IF, WB 0.1 mg Log in to see 6 to 8 Days
$742.50
Details
Human Rabbit Un-conjugated ELISA, IHC 100 μL Log in to see 16 Days
$175.80
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of COL17A1 Antibody (Center) (ABIN653043) in A375, A2058, HL-60, MCF-7 cell line lysates (35 µg/lane). COL17A1 (arrow) was detected using the purified polyclonal antibody. COL17A1 Antibody (Center) (ABIN653043) IHC analysis in formalin fixed and paraffin embedded skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of Collagen 17 alpha 1 staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then Western blot analysis of Collagen 17 alpha 1 expression in HepG2 (A), NIH3T3 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Mouse Rabbit Un-conjugated IHC (fro) Immunofluorescence staining of Collagen type XVII alpha 1 chain with Cat.No. AP23435PU-N (1:100) followed by an anti-rabbit FITC conjugated secondary antibody in cryosections of mouse skin. 0.1 mg Log in to see 6 to 8 Days
$742.50
Details
Human Mouse Un-conjugated EIA, IHC (fro), WB   0.1 mg Log in to see 6 to 8 Days
$1,589.50
Details
Human Rabbit Biotin ELISA, WB   100 μg Log in to see 7 to 9 Days
$566.50
Details
Human Rabbit Un-conjugated FACS, WB Overlay histogram showing A431 cells stained with Antibody (green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight 488 Conjugated Highly Cross-Adsorbed(OH191631) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG (1ug/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed. Western Blot at 1:2000 dilution Lane 1: A2058 whole cell lysate Lane 2: A375 whole cell lysate Lane 3: HL-60 whole cell lysate Lane 4: MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane. 400 μL Log in to see 2 to 3 Days
$515.63
Details

COL17A1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-COL17A1 Antibodies

  1. Human Polyclonal COL17A1 Primary Antibody for IHC (p), WB - ABIN951629 : Di Zenzo, Calabresi, Olasz, Zambruno, Yancey: Sequential intramolecular epitope spreading of humoral responses to human BPAG2 in a transgenic model. in The Journal of investigative dermatology 2010 (PubMed)
    Show all 2 references for 951629

  2. Human Polyclonal COL17A1 Primary Antibody for EIA, IHC (fro) - ABIN191526 : Sitaru, Schmidt, Petermann, Munteanu, Bröcker, Zillikens: Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skin. in The Journal of investigative dermatology 2002 (PubMed)
    Show all 2 references for 191526

  3. Human Monoclonal COL17A1 Primary Antibody for EIA, IHC (fro) - ABIN192032 : Olaru, Mihai, Petrescu, Zillikens, Sitaru: Generation and characterization of monoclonal antibodies against the intracellular domain of hemidesmosomal type XVII collagen. in Hybridoma (2005) 2006 (PubMed)
    Show all 2 references for 192032

More Antibodies against COL17A1 Interaction Partners

Human Collagen, Type XVII, alpha 1 (COL17A1) interaction partners

  1. The corneal dystrophy mapped to chromosome 10q23-q24 is associated with the c.3156C>T variant in COL17A1.

  2. Data suggest that type XVII collagen (COL17) internalization/macropinocytosis by keratinocytes induced by IgG autoantibodies from patients with bullous pemphigoid (show DST Antibodies) (BP) is mediated by PKC (protein kinase C (show PKC Antibodies)) calcium signaling pathway; BP IgG induced overabundant phosphorylation of COL17.

  3. we have produced five new versatile monoclonal antibodies against the Col 17 (show COL Antibodies) endodomain that are superior to ectodomain antibodies in diagnosing and differentiating between JEB-gen (show GEN1 Antibodies) intermed and JEB-loc (show ILK Antibodies)/carriers

  4. Results show that aberrant epigenetic control is a key driver of COL17A1 gene misexpression and tumor cell invasion in a variety of epithelial neoplasm. These findings have significant clinical implications, suggesting that the COL17A1 promoter methylation status can be used to predict patient outcome.

  5. Case Report: IgA autoantibodies targeting the NC16A domain rather than the shed ectodomains of COL17 resulted in linear IgA bullous dermatosis (show LAD1 Antibodies) in a pregnant woman.

  6. ELISA for IgE anti-NC16a is a helpful parameter in the modification of current treatment and the assessment of risk of relapse in bullous pemphigoid (show DST Antibodies).

  7. R1303Q in COL17 hampers C-terminal cleavage of COL17. Increase in remnants of non-cleaved COL17 ectodomain in extracellular matrix (ECM (show MMRN1 Antibodies)) induces aberrant laminin 332 deposition in ECM (show MMRN1 Antibodies), which may be associated with disorganized basement membrane formation.

  8. The COL17A1 c.3156C-->T variant is the likely causative mutation in our recurrent corneal erosion families, and its presence in 4 independent families suggests that it is prevalent in epithelial recurrent erosion dystrophy.

  9. Elevated serum levels of BP180 antibodies in the first trimester of pregnancy precede gestational pemphigoid and remain elevated for a long time after remission of the disease.

  10. Letter/Case Report: IgE BP180 antibodies contribute to the occurrence of urticarial erythema in bullous pemphigoid (show DST Antibodies) patients.

Mouse (Murine) Collagen, Type XVII, alpha 1 (COL17A1) interaction partners

  1. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in hair follicle stem cell (HFSCs), demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

  2. The deletion of the bullous pemphigoid (show DST Antibodies) epitope region of collagen XVII induces blistering, autoimmunization, and itching in a mouse disease model.

  3. Through an unbiased genetic approach involving a combination of QTL mapping and positional cloning, we demonstrate that Col17a1 is a strong genetic modifier of the non-Herlitz JEB that develops in Lamc2 (show LAMC2 Antibodies)(jeb) mice

  4. These results provide mechanistic evidence that ColXVII coordinates keratinocyte adhesion and directed motility by interfering integrin dependent PI3K activation and by stabilizing lamellipodia

  5. Neutrophil elastase (show ELANE Antibodies) cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid (show DST Antibodies)

  6. Analysis of Col17a1-null mice revealed that COL17A1 is critical for the self-renewal of hair follicle stem cells through maintaining their quiescence and immaturity.

  7. bullous pemphigoid antigen 2 has a role in eliciting specific IgG and the immune responses arising in epidermolysis bullosa

  8. ADAM9 (show ADAM9 Antibodies) and ADAM10 (show ADAM10 Antibodies) can both contribute to collagen XVII shedding in skin.

Cow (Bovine) Collagen, Type XVII, alpha 1 (COL17A1) interaction partners

  1. results show that the cleavage of BP180 occurring within the NC16A domain is mediated by a membrane-associated metalloprotease (show ADAM8 PLURAL_@27060@) and suggest involvement of the cleavage in hemidesmosomal disassembly(bullous pemphigoid antigen 180/type XVII collagen)

COL17A1 Antigen Profile

Protein Summary

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

Gene names and symbols associated with COL17A1

  • collagen, type XVII, alpha 1 (Col17a1) antibody
  • collagen, type XVII, alpha 1b (col17a1b) antibody
  • collagen, type XVII, alpha 1 (COL17A1) antibody
  • BA16H23.2 antibody
  • BP180 antibody
  • BPA-2 antibody
  • Bpag antibody
  • Bpag2 antibody
  • COL17A1 antibody
  • fk89a06 antibody
  • LAD-1 antibody
  • si:ch211-223p8.6 antibody
  • wu:fk89a06 antibody

Protein level used designations for COL17A1

collagen alpha-1(XVII) chain , procollagen, type XVII, alpha 1 , col17a1a , collagen, type XVII, alpha 1 , collagen alpha-1(XVII) chain-like , 180 kDa bullous pemphigoid antigen 2 , alpha 1 type XVII collagen , bA16H23.2 (collagen, type XVII, alpha 1 (BP180)) , bullous pemphigoid antigen 2 (180kD) , collagen XVII, alpha-1 polypeptide , bullous pemphigoid antigen 2 , bullous pemphigoid antigen 180 , novel collagen protein , Collagen alpha-1(XVII) chain , bullous pemphigoid autoantigen 2 , Bullous pemphigoid antigen 2 , collagen type XVII

GENE ID SPECIES
294027 Rattus norvegicus
568794 Danio rerio
100452122 Pongo abelii
100069671 Equus caballus
100604365 Nomascus leucogenys
1308 Homo sapiens
12821 Mus musculus
513804 Bos taurus
396503 Gallus gallus
403739 Canis lupus familiaris
101843802 Mesocricetus auratus
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