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COL18A1 encodes the alpha chain of type XVIII collagen. Additionally we are shipping COL18A1 Antibodies (185) and COL18A1 Kits (71) and many more products for this protein.
Showing 10 out of 20 products:
Human COL18A1 Protein expressed in Escherichia coli (E. coli) - ABIN2666547
Faye, Chautard, Olsen, Ricard-Blum: The first draft of the endostatin interaction network. in The Journal of biological chemistry 2009
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Mouse (Murine) COL18A1 Protein expressed in HEK-293 - ABIN2666580
Sund, Hamano, Sugimoto, Sudhakar, Soubasakos, Yerramalla, Benjamin, Lawler, Kieran, Shah, Kalluri: Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors. in Proceedings of the National Academy of Sciences of the United States of America 2005
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Investigate the timecourse of collagen XVIII processing with release of endostatin (ES) and other low-molecular-weight fragments during early ischemia-reperfusion of the heart.
Together these data suggest that Lh3 (show PLOD3 Proteins)-Collagen18A1 dependent ECM (show MMRN1 Proteins) modifications regulate the transition of trunk neural crest cells from a non-segmental sheet like migration mode to a segmental stream migration mode
These results provide important insight into the biological function and regulation of COL18A1, and point to additional sequences that may contribute to complex diseases involving COL18A1.
diwanka (lh3 (show PLOD3 Proteins)) acts through myotomal type XVIII collagen, a ligand for neural-receptor protein tyrosine phosphatases that guide motor axons
Two COL18A1 variants co-segregated with familial epilepsy and anterior polymicrogyria in a family.
Blood endostatin wasdddddddddddddddddddddddddf significantly higher in chronic hepatitis C patients with liver fibrosis compared to those without fibrosis.
The homozygous DN and NN genotypes of COL18A1 D104N were associated with the risk of osteosarcoma.
Endostatin is increased in patients with primary sjogren's syndrome patients with interstitial lung disease.
Data show that endostatin levels were elevated in patients with systemic sclerosis (SSc (show CYP11A1 Proteins)) and mixed connective tissue disease (MCTD).
Collaterals formation seems to be associated with the activation of pro-inflammatory factors, growth factors and endostatin in chronic heart failure.
Genebased analyses revealed associations of the COL18A1 gene with longitudinal Blood Pressure phenotypes, associations with essential hypertension, Blood Pressure salt sensitivity, preeclampsia, or preclinical stages of atherosclerosis.
Study demonstrates that endostatin has novel ATPase activity, which mediates its antiangiogenic and antitumor activities.
ADAM8 and endostatin play a role in osteosarcoma progression.
the intima+media of IPAH vessels, collagens (COL4A5 (show COL4a5 Proteins), COL14A1 (show COL14A1 Proteins), and COL18A1), matrix metalloproteinase (MMP) 19 (show MMP19 Proteins), and a disintegrin and metalloprotease (ADAM) 33 (show ADAM33 Proteins) were higher expressed, whereas MMP10 (show MMP10 Proteins), ADAM17 (show ADAM17 Proteins), TIMP1 (show TIMP1 Proteins), and TIMP3 (show TIMP3 Proteins) were less abundant.
Kidney fibrosis in aging may represent a natural outcome of upregulated endostatin (EST (show MAP3K8 Proteins)) and transglutaminase 2 (TG2 (show TGM2 Proteins)), but more likely it appears to be a result of cumulative stresses occurring on the background of synergistically acting geronic (aging) proteins, EST (show MAP3K8 Proteins) and TG2 (show TGM2 Proteins).
There are correlations between the elevation of endostatin levels and parallel microvascular rarefaction and induction of renal fibrosis in aging mice.
An excess of the collagen XVIII Tsp-1 (show GZMA Proteins) domain is deleterious in the eye, possibly by impairing certain functions of the full-length molecule.
The results of the present study indicate endostatin promotes soft callus formation but inhibits callus remodeling during fracture healing most probably by an inhibition of angiogenesis.
Data indicate that delivery by attenuated Salmonella of the combination therapeutic plasmid simultaneously knocked down the expression of Stat3 (show STAT3 Proteins) and resulted in over-expression of Endostatin, which synergistically inhibited prostate cancer growth.
Endostatin lowers blood pressure via nitric oxide and prevents hypertension associated with VEGF inhibition
Women with early-onset, but not late-onset preeclampsia have higher levels of endostatin than healthy pregnant women in corresponding lengths of gestation.
In vivo, Collagen XVIII/endostatin does not play an indispensable role in skeletal development
Lack of collagen XVIII/endostatin results in eye abnormalities.
Endostatin gene transfer inhibits joint angiogenesis and pannus formation in inflammatory arthritis
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
collagen, type XVIII, alpha 1
, alpha 1 type XVIII collagen
, collagen alpha-1(XVIII) chain
, procollagen, type XVIII, alpha 1
, collagen alpha-1(XVIII) chain-like
, antiangiogenic agent
, multi-functional protein MFP