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Collagen, Type XXV, alpha 1 (COL25A1) ELISA Kits

COL25A1 encodes a brain-specific membrane associated collagen. Additionally we are shipping COL25A1 Antibodies (60) and COL25A1 Proteins (8) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human COL25A1 COL25A1 84570 Q9BXS0
Anti-Mouse COL25A1 COL25A1 77018 Q99MQ5
Anti-Rat COL25A1 COL25A1 687064  
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More ELISA Kits for COL25A1 Interaction Partners

Human Collagen, Type XXV, alpha 1 (COL25A1) interaction partners

  1. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder.

  2. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia

  3. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence.

  4. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25

  5. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease

  6. COL25A1 leads to Alzheimer's disease-like pathology in vivo

  7. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide

  8. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases.

  9. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta (show APP ELISA Kits) fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth

Mouse (Murine) Collagen, Type XXV, alpha 1 (COL25A1) interaction partners

  1. CLAC-P/collagen XXV is a novel essential factor that regulates the initial phase of intramuscular motor innervation, which is required for subsequent target-dependent motoneuron survival and neuromuscular junction formation during development.

  2. COL25A1 leads to Alzheimer's disease-like pathology in vivo

COL25A1 Antigen Profile

Antigen Summary

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with COL25A1

  • collagen, type XXV, alpha 1 (COL25A1) antibody
  • collagen, type XXV, alpha 1 (col25a1) antibody
  • collagen, type XXV, alpha 1 (Col25a1) antibody
  • 2700062B08Rik antibody
  • AMY antibody
  • CLAC antibody
  • CLAC-P antibody
  • CLACP antibody
  • COL25A1 antibody

Protein level used designations for COL25A1

collagen, type XXV, alpha 1 , collagen, type XXV, alpha 1-like , collagen alpha-1(XXV) chain-like , alzheimer disease amyloid-associated protein , collagen alpha-1(XXV) chain , collagen-like Alzheimer amyloid plaque component , collagenous Alzheimer amyloid plaque component , procollagen, type XXV, alpha 1

429900 Gallus gallus
461429 Pan troglodytes
610442 Canis lupus familiaris
615661 Bos taurus
697122 Macaca mulatta
100072894 Equus caballus
100449602 Pongo abelii
100564591 Anolis carolinensis
100589227 Nomascus leucogenys
84570 Homo sapiens
77018 Mus musculus
687064 Rattus norvegicus
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