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This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Additionally we are shipping CTHRC1 Antibodies (67) and CTHRC1 Kits (10) and many more products for this protein.
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Human CTHRC1 Protein expressed in Human Cells - ABIN2004469
Pyagay, Heroult, Wang, Lehnert, Belden, Liaw, Friesel, Lindner: Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. in Circulation research 2005
Show all 2 references for ABIN2004469
Authors showed that ectopic transfection of CTHRC1 in EOC cells up-regulated the expression of EMT (show ITK Proteins) markers such as N-cadherin (show CDH2 Proteins) and vimentin (show VIM Proteins), and EMT (show ITK Proteins)-associated transcriptional factor Snail (show SNAI1 Proteins).
CTHRC1 is secreted both by colorectal epithelia cells and stromal fibroblasts. CTHRC1 overexpression promotes colorectal cancer cell migration, invasion and proliferation in vitro.
determined the mRNA and protein expression of CTHRC1 in oral squamous cell carcinoma and evaluated the clinical and prognostic impact of CTHRC1 overexpression
CTHRC1 has a novel role in viral infection.
HBV facilitates HCC (show FAM126A Proteins) development through activating the oncoprotein CTHRC1.
CTHRC1 was overexpressed in human non-small cell lung cancer tissues and non-small cell lung cancer cell lines at the protein and mRNA level.
let-7b may directly target Cthrc1 and function as a tumor suppressor gene in gastric cancer.
CTHRC1 acts as a prognostic factor and promotes invasiveness of gastrointestinal stromal tumors by activating Wnt (show WNT2 Proteins)/PCP (show PRCP Proteins)-Rho signaling.
Cthrc1 overexpression was associated with non-small cell lung cancers.
Cthrc1 is a pituitary hormone with significantly elevated levels in subjects carrying variant alleles of the melanocortin-1 receptor as wells as in patients with inflammatory conditions.
CTHRC1 is an osteoclast-secreted coupling factor that regulates bone remodeling.
This study demonstrated that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination.
this is the first demonstration of Cthrc1 as a marker of the severity of the disease progression in the dystrophic muscles.
Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen (show GYS1 Proteins) levels with potentially broad implications for cell metabolism and physiology.
Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb (show PDGFRB Proteins) promoter driven Cre dependent myc (show MYC Proteins)-tagged Cthrc1 transgene expression.
Downregulated by dietary beta-carotene in lungs of knockout Bcmo1 (show BCMO1 Proteins)-deficient mice.
Cthrc1 expression overlaps considerably with those reported for TGF-beta (show TGFB1 Proteins) family members and interstitial collagens.
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Cthrc1 increases bone mass as a positive regulator of osteoblastic bone formation
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
collagen triple helix repeat containing 1
, collagen triple helix repeat-containing protein 1