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This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Additionally we are shipping CTHRC1 Antibodies (69) and CTHRC1 Kits (12) and many more products for this protein.
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Human CTHRC1 Protein expressed in Human Cells - ABIN2004469
Pyagay, Heroult, Wang, Lehnert, Belden, Liaw, Friesel, Lindner: Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. in Circulation research 2005
Show all 2 references for ABIN2004469
Gene expression levels of three randomly selected DEGs (show DEGS1 Proteins), VCAN (show Vcan Proteins), COL5A1 and KCNJ16 (show KCNJ16 Proteins), were examined using RT-PCR in 10 ATC (show SRPK1 Proteins) samples.. angiogenesis was activated by the high expression of CTHRC1, VCAN (show Vcan Proteins) and POSTN (show POSTN Proteins), providing necessary nutrition for tumor cells
increased CTHRC1 expression is associated with advanced TNM (show ODZ1 Proteins) stage, increased LN metastasis and tumor size, and decreased OS and DFS (show FST Proteins), indicating that CTHRC1 may be a biomarker for prognosis of cancer patients
High CTHRC1 expression is associated with Osteosarcoma.
Authors showed that ectopic transfection of CTHRC1 in EOC cells up-regulated the expression of EMT (show ITK Proteins) markers such as N-cadherin (show CDH2 Proteins) and vimentin (show VIM Proteins), and EMT (show ITK Proteins)-associated transcriptional factor Snail (show SNAI1 Proteins).
CTHRC1 is secreted both by colorectal epithelia cells and stromal fibroblasts. CTHRC1 overexpression promotes colorectal cancer cell migration, invasion and proliferation in vitro.
determined the mRNA and protein expression of CTHRC1 in oral squamous cell carcinoma and evaluated the clinical and prognostic impact of CTHRC1 overexpression
CTHRC1 has a novel role in viral infection.
HBV facilitates HCC (show FAM126A Proteins) development through activating the oncoprotein CTHRC1.
CTHRC1 was overexpressed in human non-small cell lung cancer tissues and non-small cell lung cancer cell lines at the protein and mRNA level.
let-7b may directly target Cthrc1 and function as a tumor suppressor gene in gastric cancer.
CTHRC1 is an osteoclast-secreted coupling factor that regulates bone remodeling.
This study demonstrated that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination.
this is the first demonstration of Cthrc1 as a marker of the severity of the disease progression in the dystrophic muscles.
Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen (show GYS1 Proteins) levels with potentially broad implications for cell metabolism and physiology.
Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb (show PDGFRB Proteins) promoter driven Cre dependent myc (show MYC Proteins)-tagged Cthrc1 transgene expression.
Downregulated by dietary beta-carotene in lungs of knockout Bcmo1 (show BCMO1 Proteins)-deficient mice.
Cthrc1 expression overlaps considerably with those reported for TGF-beta (show TGFB1 Proteins) family members and interstitial collagens.
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Cthrc1 increases bone mass as a positive regulator of osteoblastic bone formation
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
collagen triple helix repeat containing 1
, collagen triple helix repeat-containing protein 1