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CRMP1 encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. Additionally we are shipping CRMP1 Antibodies (110) and CRMP1 Kits (3) and many more products for this protein.
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Human CRMP1 Protein expressed in Human - ABIN2712565
Braunschweig, Krakowiak, Duncanson, Boyce, Hansen, Ashwood, Hertz-Picciotto, Pessah, Van de Water: Autism-specific maternal autoantibodies recognize critical proteins in developing brain. in Translational psychiatry 2013
miR200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating CRMP1.
CRMP1 interacted with Spy1 (show SPDYA Proteins) which would disturb the association of CRMP1 with actin and was involved in the collapse of growth cones induced by Sema3A (show SEMA3A Proteins) and regeneration after sciatic nerve crush.
These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2 (show ACTR2 Proteins)/3 activation.
Human CRMP-1 comprises a tetrameric assembly.
Results show that expression of CRMP1 is downregulated in medulloblastoma (MB) tumors. its overexpression inhibits proliferation, migration and invasion of cells suggesting that CRMP1 is implicated in MB pathogenesis.
Aberrant upregulation of CRMP-1 expression may link to the mechanism of developing early-onset preeclampsia.
CRMP1 targets aggregation-prone, N-terminal HTT (show HTT Proteins) fragments and suppresses their spontaneous self-assembly.
in pilocarpine-induced animal model of epilepsy, CRMP-1 dynamically decreased in a range of 2 months. Thus, our results indicate that CRMP-1 may be involved in the development of TLE
CRMP1 is a novel candidate protein for schizophrenia traits
GSK3beta-dependent phosphorylation of LCRMP (show DPYSL3 Proteins)-1 provides an important mechanism for regulation of LCRMP (show DPYSL3 Proteins)-1 on cancer cell invasiveness and clinical outcome.
We generated CRMP2 (show DPYSL2 Proteins) gene-deficient (crmp2 (show DPYSL2 Proteins)(-/-) ) mice. The crmp2 (show DPYSL2 Proteins)(-/-) mice showed irregular development of dendritic spines in cortical neurons. The level of CRMP1 was increased in crmp2 (show DPYSL2 Proteins)(-/-) , but the level of CRMP2 (show DPYSL2 Proteins) was not altered in crmp1(-/-).The phenotypic defects had no genetic interaction between crmp1 and crmp2 (show DPYSL2 Proteins).
LCRMP (show DPYSL3 Proteins)-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis
Data demonstrate that CRMP1 tyrosine 504 is a primary target of the Src (show SRC Proteins) family of tyrosine kinases (SFKs), specifically Fyn (show FYN Proteins).
Data link the reduction in PMCA2 (show ATP2B2 Proteins) expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA (show GRIA3 Proteins)/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE.
The structural bases for Crmp1 function in plexin-dependent sempahorin3A signaling were studied.
In the olfactory bulb, CRMP1, CRMP2 (show DPYSL2 Proteins) and CRMP5 (show DPYSL5 Proteins) are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons.
Mice lacking Crmp1 showed a decrease in the number of granule cells migrating out of explants of developing cerebellum.
Collapsin response mediator protein 1 (CRMP1)regulates neuronal migration by mediating Reelin (show RELN Proteins) signaling.
CRMP-1 may be involved in proper neurite outgrowth in the adult hippocampus. Loss of CRMP-1 may affect LTP (show SCP2 Proteins) maintenance and spatial learning and memory.
These findings suggest that Sema3A (show SEMA3A Proteins)-induced spine development is regulated by phosphorylation of CRMP1 by Cdk5 (show CDK5 Proteins).
Crmp1 is expressed in numerous sites in the developing nervous system
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.
collapsin response mediator protein 1
, cysteine repeat modular protein 1, putative
, dihydropyrimidinase related protein-1
, dihydropyrimidinase-like 1
, dihydropyrimidinase-related protein 1
, unc-33-like phosphoprotein 3
, collapsin response mediator protein-1B