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COLEC11 encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Additionally we are shipping COLEC11 Kits (16) and COLEC11 Proteins (11) and many more products for this protein.
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The exclusion of the MASP1 (show MASP1 Antibodies) and COLEC11 Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome
identify collectin (show MBL2 Antibodies) CL-LK as a novel soluble C-type lectin (show MBL2 Antibodies) able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK
Data indicate differences in the plasma concentrations of collectin liver 1 (show COLEC10 Antibodies) and collectin (show MBL2 Antibodies) kidney 1 (show ZNF354A Antibodies), M-ficolin (show FCN1 Antibodies) and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.
promoter polymorphism COLEC11-9570C>T (rs3820897) was associated with decreased levels of CL-K1.
the sugar specificity of CL-K1 was established.
These results suggest that specific diseases may affect CL-K1 synthesis in an organ dependent manner and that elevated plasma CL-K1 levels are associated with the presence of DIC (show SLC25A10 Antibodies).
Most plasma CL-K1 was found in complex with CL-L1 (show COLEC10 Antibodies) in a ratio suggesting a heteromeric subunit of 1 CL-L1 (show COLEC10 Antibodies) & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2 (show MASP2 Antibodies), the complex deposited C4b (show C4B Antibodies).
Data suggest that collectin 11 (CL-11), e.g. via complement, may play a role in response to particles and surfaces presenting extracellular DNA, such as apopototic cells.
collectin-11 associates with all the known MBL (show MBL2 Antibodies)-associated serine proteases (MASP-1 (show MASP1 Antibodies), MASP-2 (show MASP2 Antibodies) and MASP-3 (show MASP1 Antibodies)) as well as the lectin complement pathway regulator MAP-1 (show MASP1 Antibodies).
Data show that the concentration of collectin (show MBL2 Antibodies) kidney 1 (show ZNF354A Antibodies) (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL (show MBL2 Antibodies)) was 1.72 +/- 1.51 microg/ml.
intrarenal expression of COLEC11 rapidly increases in the postischemic period and colocalizes with complement deposited along the basolateral surface of the proximal renal tubule in association with L-fucose, the potential binding ligand for COLEC11.
identify collectin (show MBL2 Antibodies) CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK
This profile of CL-K1 expression is unique among the collectins. [CL-K1]
This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
collectin sub-family member 11
, collectin kidney protein 1
, collectin 2